This book introduces readers to a variety of tools for analog layout design automation. After discussing the placement and routing problem in electronic design automation (EDA), the authors overview a variety of automatic layout generation tools, as well as the most recent advances in analog layout-aware circuit sizing. The discussion includes different methods for automatic placement (a template-based Placer and an optimization-based Placer), a fully-automatic Router and an empirical-based Parasitic Extractor. The concepts and algorithms of all the modules are thoroughly described, enabling readers to reproduce the methodologies, improve the quality of their designs, or use them as starting point for a new tool. All the methods described are applied to practical examples for a 130nm design process, as well as placement and routing benchmark sets.

This book introduces readers to a variety of tools for automatic analog integrated circuit (IC) sizing and optimization. The authors provide a historical perspective on the early methods proposed to tackle automatic analog circuit sizing, with emphasis on the methodologies to size and optimize the circuit, and on the methodologies to estimate the circuit's performance. The discussion also includes robust circuit design and optimization and the most recent advances in layout-aware analog sizing approaches. The authors describe a methodology for an automatic flow for analog IC design, including details of the inputs and interfaces, multi-objective optimization techniques, and the enhancements made in the base implementation by using machine leaning techniques. The Gradient model is discussed in detail, along with the methods to include layout effects in the circuit sizing. The concepts and algorithms of all the modules are thoroughly described, enabling readers to reproduce the methodologies, improve the quality of their designs, or use them as starting point for a new tool. An extensive set of application examples is included to demonstrate the capabilities and features of the methodologies described.

This book focuses on the impact of political leaders on the integration process led by the European Union. It aims at a better understanding of the European Union through the actions, contributions, and ideas of these outstanding characters to European integration and disintegration. By doing so, the book offers an entirely new perspective, presenting the actions of the main actors involved, their background, their historical time, their challenges and problems, and how they influenced the European Union's development. The authors in detail discuss different ideas connected to leaders, such as Jean Monnet and neo-functionalism, Spinelli and federalism or Churchill and the idea of cooperation. Furthermore, the book examines major policies and events, like the Common Agricultural Policy, the creation of the Euro as a consequence of the German reunification and Mitterrand's reactions, or Brexit and its connection to the impact of Margaret Thatcher. The global essence of the book makes it a must-read for students, researchers, and scholars interested in a better understanding of the European Union's integration process.

In the light of Brexit, the migration crisis, and growing scepticism regarding the European integration process, this book offers a comprehensive overview of the most pressing problems facing the European Union in the 21st century. Written by experts from various disciplines, the contributions cover a wide range of economic, legal, social and political challenges, including populism, migration, Brexit, and EU defence, foreign policy and enlargements. Each paper includes a historical account, insights into the problems and challenges confronting the EU, and an assessment of the institutions and policy instruments applied by the EU in response. Discussing each of the problems as part of a process - including the historical roots, current situation and potential solutions - the book allows readers to gain an understanding of the European Union as a living project.

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. "Animal Models of Brain Tumors" brings together developments and discoveries in in vivo experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular "Neuromethods "series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results.

Authoritative and cutting-edge, "Animal Models of Brain Tumors" provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments."

Modernity of Religiosities and Beliefs: A New Path in Latin America From the Nineteenth to Twenty-First Century synthesizes new research on various phenomena related to religions and beliefs in Latin America. The contributors provide comprehensive analytical interpretations of Latin American spheres of religious ideas and worldviews and show that they are a key element to understanding the history of the region. Overall, this book gives an account of the whole spectrum of religious phenomena in Latin American societies, providing a "global" interpretation that will contribute to the study of political, economic, and cultural modernities in Latin America.

On the morning of 24 December 1943, 542 Squadron’s intelligence officer briefed Flt Lt J. Storey on covering Crossbow sites in the Calais-Abbeville areas. He was airborne at 11 a.m. and set course in his Spitfire for the French coast, passing over London at 15,000 feet. The weather was perfect over the Channel, so he levelled off and ‘harried’ to Dunkirk and then set course to Abbeville. Some 50 miles before reaching the objective, noisy oscillations in his earphones gave warning that the German anti-aircraft battery caught the intruder aircraft in the radar beam they used to direct fire. Occasionally, he rolled the Spitfire up on her side to check beneath him. To conserve fuel, he began a gradual climb up through 40,000 feet and levelled off at 41,500 feet. Over the objective, he lined up the aircraft and began his runs. He took photos of everything on his list of objectives. Unmolested by flak, he spent as much time over the objective as possible and then turned home. As he was flying over the North Sea, he was unaware that a special trip was waiting for him in a not so far future.

In the light of Brexit, the migration crisis, and growing scepticism regarding the European integration process, this book offers a comprehensive overview of the most pressing problems facing the European Union in the 21st century. Written by experts from various disciplines, the contributions cover a wide range of economic, legal, social and political challenges, including populism, migration, Brexit, and EU defence, foreign policy and enlargements. Each paper includes a historical account, insights into the problems and challenges confronting the EU, and an assessment of the institutions and policy instruments applied by the EU in response. Discussing each of the problems as part of a process - including the historical roots, current situation and potential solutions - the book allows readers to gain an understanding of the European Union as a living project.

This book introduces readers to a variety of tools for automatic analog integrated circuit (IC) sizing and optimization. The authors provide a historical perspective on the early methods proposed to tackle automatic analog circuit sizing, with emphasis on the methodologies to size and optimize the circuit, and on the methodologies to estimate the circuit's performance. The discussion also includes robust circuit design and optimization and the most recent advances in layout-aware analog sizing approaches. The authors describe a methodology for an automatic flow for analog IC design, including details of the inputs and interfaces, multi-objective optimization techniques, and the enhancements made in the base implementation by using machine leaning techniques. The Gradient model is discussed in detail, along with the methods to include layout effects in the circuit sizing. The concepts and algorithms of all the modules are thoroughly described, enabling readers to reproduce the methodologies, improve the quality of their designs, or use them as starting point for a new tool. An extensive set of application examples is included to demonstrate the capabilities and features of the methodologies described.

This book introduces readers to a variety of tools for analog layout design automation. After discussing the placement and routing problem in electronic design automation (EDA), the authors overview a variety of automatic layout generation tools, as well as the most recent advances in analog layout-aware circuit sizing. The discussion includes different methods for automatic placement (a template-based Placer and an optimization-based Placer), a fully-automatic Router and an empirical-based Parasitic Extractor. The concepts and algorithms of all the modules are thoroughly described, enabling readers to reproduce the methodologies, improve the quality of their designs, or use them as starting point for a new tool. All the methods described are applied to practical examples for a 130nm design process, as well as placement and routing benchmark sets.

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in "in vivo" experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

In this book, innovative research using artificial neural networks (ANNs) is conducted to automate the placement task in analog integrated circuit layout design, by creating a generalized model that can generate valid layouts at push-button speed. Further, it exploits ANNs' generalization and push-button speed prediction (once fully trained) capabilities, and details the optimal description of the input/output data relation. The description developed here is chiefly reflected in two of the system's characteristics: the shape of the input data and the minimized loss function. In order to address the latter, abstract and segmented descriptions of both the input data and the objective behavior are developed, which allow the model to identify, in newer scenarios, sub-blocks which can be found in the input data. This approach yields device-level descriptions of the input topology that, for each device, focus on describing its relation to every other device in the topology. By means of these descriptions, an unfamiliar overall topology can be broken down into devices that are subject to the same constraints as a device in one of the training topologies. In the experimental results chapter, the trained ANNs are used to produce a variety of valid placement solutions even beyond the scope of the training/validation sets, demonstrating the model's effectiveness in terms of identifying common components between newer topologies and reutilizing the acquired knowledge. Lastly, the methodology used can readily adapt to the given problem's context (high label production cost), resulting in an efficient, inexpensive and fast model.

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