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In this work Philip Hadley provides a comprehensive discussion of
the immense body of prior work on the occurrence of dissociation of
bacterial forms, including much accomplished even prior to the
start of the Twentieth Century. Hadley's work has apparently,
unfortunately, not previously been published independently in book
form, which may help explain why this exhaustive treatise has thus
far evaded a more-deserved and widespread audience.
The title paper in this compilation, "Filtrable Bacteria," was
published in the Journal of Infectious Diseases in 1931. This was
the third in a series dealing with the subject of bacterial
variability. The first ("Microbic Dissociation") was published in
1927, and the second ("The Twort-d'Herelle Phenomenon") in 1928.
"Filtrable Bacteria" continues the study of dissociative variations
among bacteria, and addresses the method of production, the
cultural behavior, the morphology and the filterability of what may
be termed "the filterable virus stage" of the Shiga dysentery
bacillus. PHILIP HADLEY This present compilation also incorporates
a 1937 article, "Further Advances in the Study of Microbic
Dissociation."
The working hypothesis ... is that the bacteriophage is either a
definite stage in the cyclogeny of the bacterial species, or a
functionally active particle accessory to one of these stages; and
by the term "accessory" I mean possessing complementary or
reciprocal biologic significance, such, for example, as the
relation of sperm cell to ovum. With such a conception there is not
any priority of significance in the relation between bacteriophagic
corpuscle and the cell which it "attacks." Both elements are
necesary components of a definite reproductive mechanism possessed
by many, if not all, bacteria. This constitutes the nucleus of what
I have termed my "homogamic theory" of bacteriophage action. PHILIP
HADLEY
Frank Billings' classic and forever relevant 1916 masterpiece, with
a 2013 Foreword by S. H. Shakman of the Institute Of Science
(www.InstituteOfScience.com) "Four Score and Seventeen Years Ago,"
providing an historical review and update on the subject of the
relation between oral infections and systemic diseases.
A review and compilation of key works on the relation between
dental infections and mental illnesses, with an introduction and
overview of the definitive bacteriological work of E.C Rosenow of
the Mayo Foundation, by S. H. Shakman, and incorporating the
foundational historical works by Henry Upson and Henry Cotton.
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