This volume offers the most comprehensive, up-to-date description of the wide array of second language programs currently available to undergraduate students in the United States and abroad. It brings together, for the first time, detailed descriptions of programs in foreign language, English as a second language (ESL), dual language (bilingual), American Sign Language, Native American, and heritage languages. Addressing both theory and practice, the volume presents the historical development, current practices, and future directions of each type of program, along with detailed case studies. For second language teachers, academic administrators, and teacher educators, this "Handbook" provides information that will be useful in making instructional and programmatic planning decisions.

This volume offers the most comprehensive, up-to-date description of the wide array of second language programs currently available to undergraduate students in the United States and abroad. It brings together, for the first time, detailed descriptions of programs in foreign language, English as a second language (ESL), dual language (bilingual), American Sign Language, Native American, and heritage languages. Addressing both theory and practice, the volume presents the historical development, current practices, and future directions of each type of program, along with detailed case studies. For second language teachers, academic administrators, and teacher educators, this "Handbook" provides information that will be useful in making instructional and programmatic planning decisions.

This book is carefully designed to inform and train readers in the techniques of content-based ESL instruction and to assist them in developing and implementing content-based materials and programs appropriate to their educational institutions and situations. Every chapter presents a balance of theory and practice, focusing on a detailed description, with clear examples of classroom practices including information, suggestions, and instructional tools. Each chapter addresses assessment issues as they apply to the particular methodology described.

This book is carefully designed to inform and train readers in the techniques of content-based ESL instruction and to assist them in developing and implementing content-based materials and programs appropriate to their educational institutions and situations. Every chapter presents a balance of theory and practice, focusing on a detailed description, with clear examples of classroom practices including information, suggestions, and instructional tools. Each chapter addresses assessment issues as they apply to the particular methodology described.

The four contributions by Ishibashi et al., Klussmann et al., Zeuthen and Larsen et al. summarize the current knowledge on the molecular mechanisms underlying the short and long term regulation of water channels (AQPs) in principal cells, fluid transport by leaky epithelia and cotransporters of the symport type which behave as molecular water pumps.

"Fifteen years before the Enron, WorldCom, and Parmalat debacles, another company embarked on a strategy that appeared to be driven more by the allure of short-term profits and compensation for management than by the long-term interests of shareholders. In this case, though, the risks those managers took extended beyond the purely financial to the safety of several large nuclear power plants. A sobering tale, told fairly and skillfully."--Paul Portney, President, Resources for the Future

"MacAvoy and Rosenthal paint a vivid picture of a board of directors ignoring not just red flags, but explicit warnings of the impending calamity, while being calmed by a complacent management. Their book serves as a warning to be absorbed by all boards that diligence, surely post-Enron, requires more than probing the bottom line; it includes all risks to the enterprise, probing beyond management assurances, and appropriate information flow to, and leadership of, the board."--Ira M. Millstein, Senior Partner, Weil, Gotshal & Manges LLP and Chairman of the Private Sector Advisory Group of the World Bank/OECD Global Corporate Governance Forum

"This story is important for anyone with an interest in corporate governance. It makes clear the conflicts that develop and the danger to shareholders when an industry structure changes, but executive compensation systems do not. MacAvoy and Rosenthal provide a penetrating analysis of Northeast's nuclear negligence. At Northeast, an electric utility, regulation was giving way to competition, but no change was occurring in nuclear safety requirements. Northeast executives, whose short-term compensation incentives were based on income, cut nuclear operating andmaintenance costs, making safety violations and plant shutdowns inevitable in the long term. Shareholders suffered while executives were unscathed."--Richard Bower, Leon E. Williams Professor of Finance and Managerial Economics, Emeritus, Tuck School of Business at Dartmouth College

"This book provides an entertaining and informative look at the implications of competition for nuclear safety. It should be read widely."--R. Preston McAfee, J. Stanley Johnson Professor of Business, Economics, and Management, California Institute of Technology, author of "Competitive Solutions: The Strategist's Toolkit"

"Paul MacAvoy and Jean Rosenthal offer an interesting discussion of one of the unforeseen problems associated with deregulating the electric utility industry. Their book will serve as a useful warning to other nuclear power plant operators--and operators in other safety-critical industries, such as airlines--that safety is a constraint, not a variable, in maximizing profits."--Geoffrey Rothwell, Stanford University

Jetzt vollstandig uberarbeitet und in allen Teilen aktualisiert: Auch die 3. Auflage dieses bewahrten Lehrbuchs bietet wieder alles, was man uber die Pharmakologie und Toxikologie wissen muss. Umfassend und zugleich kompakt bietet es einen hervorragenden UEberblick uber die Wirkungen der wichtigsten Arzneistoffe und -stoffklassen.

This book presents the latest research on advances in genetics, molecular medicine, biotechnologies, and behavioural sciences that have an impact on primary, secondary and tertiary cancer prevention including: (a) Basic mechanisms of neoplastic diseases leading to the identification of molecular pathways that can be employed as targets for cancer prevention; (b) Descriptive, analytical, and molecular epidemiology with emphasis on developing biomarkers of cancer risk assessment and response to cancer prevention; (c) Laboratory and clinical procedures for prognostic evaluation of malignant tumour transformation, progression and response to treatment with cancer preventive agents; (d) Discoveries of natural substances and synthetic agents that have promising cancer preventive potential and elucidating their mechanistic action; (e) Development and assessment of cancer preventive approaches that have potential for being translated into the clinic; (f) Cancer prevention pre-clinical studies and clinical trials; (g) Patient management and education, management of curable lesions, education and lifestyle modification and the role of behavioural factors in cancer etiology and prevention.