Clinical trials are the most definitive tool for evaluation of the applica bility of clinical investigations. The main objective of clinical investiga tions is to assess the potential value of a therapeutic entity in the treat ment or prophylaxis of a disease or a condition. It is also deemed necessary at this stage to obtain information regarding the undesirable side effects, associated risks, and their interrelationship with clinical assessments. Most of these clinical investigations conform, in some form or fashion, to the guidelines adopted by the Food and Drug Administration (FDA) for a given class of compounds. Clinical investigations in the past have not included specific studies in special or subpopulations, e.g., the elderly. Because of an ever-increasing elderly population, newer policies for clinical investigations are now being debated with the recognition of enhanced drug sensitivity in this special population. This key research activity can lead not only to improved health care in the elderly but also to control of its costs."

Guide to Fitness After Fifty presents basic and applied research data, authoritative advice and tested techniques for professional workers who want to learn more about physical exercise, fitness and health for aging people and for all who seek to become more physically and mentally fit. The editors and contributors believe that physical activity and exercise following the pri ciples and practices utlined in this inter disciplinary volume can improve the health and quality of life by increasing en durance and cardiovascular fitness, strengthening the musculoskeletal system, im proving mobility, posture and appearance, and relaxing emotional tensions. Evidence at hand and discussed in this book demonstrates that properly prescribed physical activity or exercise can raise the level of physical fitness and health, both physical and mental, at any age, delay the ravages of aging, and prevent or reduce disability from musculoskeletal and circulatory disorders. Section I, Perspectives on Exercise and Aging, surveys the fundamental problems and relationships of exercise to aging and health and provides historical insights and philosophic perspectives on the significance and importance of physical fitness and exercise through the centuries and in contemporary society. Section II, Evaluation and Physiology of Exercise, presents objective scientific and medical evidence that reasonable improvement in fitness and other bodily func tions may be achieved by people of all ages who follow well designed exercise and relaxation routines for at least 30 minutes three or more times weekly."

EDITORS Hans V AN DEN BREKEL * and Fred DEVEN** * NIDI, P. O. Box 11650, 2502 AR The Hague, The Netherlands ** CBGS, Markiesstraat 1, 1000 Brussels, Belgium The series "Population and Family in the Low Countries" (POPFAM), established in 1976, aims to introduce selected issues of demographic research in Flanders/Belgium and the Netherlands to an international audience. The publication series results from cooperation between the Nether lands Interdisciplinary Demographic Institute (NIDI, The Hague) and the Flemish Population and Family Study Centre (CBGS, Brussels). This 1995 edition is the 111h in the series. In 1995, the NIDI celebrates its 25th anniversary as the Dutch national demographic institute, making it a special year for Dutch demography. The contents of this publication obviously highlights this event as most articles selected for this edition are written by Dutch or NIDI related scholars. The article "Ageing and the demand for care: scenario studies for Europe" by Hanna van Solinge and Jenny de Jong Gierveld concerns a comparative study with respect to the consequences of ageing populations for the infrastructure of care for the elderly. It presents results of a scenario study on future developments in demand and supply of elderly care services for a selected number of European countries, summarizing an extensive study on the impact of ageing populations on the socio-medical system conducted by the authors on behalf of the European Population Committee of the Council of Europe.

Exploring pressing questions around Canadian citizenship, Canada in Question delves into contemporary issues that come into play in identifying what it means to be Canadian. Beginning with an update on the status of Canadian citizenship, Peter MacKinnon acknowledges that with the exception of Indigenous peoples, most Canadians migrated to Canada in the last 400 years. In surveying the status of citizenship, the author addresses the impact of these newcomers on Indigenous peoples, and the subsequent impression that the following influx of new immigrants and migrants has had on citizenship. MacKinnon investigates the ties that bind Canadians to their country and to their fellow citizens, and how these ties are often challenged by global influences, such as identity politics and social media. Shedding light on the connection between economic opportunity and citizenship, and on the institutional context in which differences must be accommodated, Canada in Question examines current circumstances and new challenges, and looks to the unique future of Canadian citizenship.

Does human mortality after age 110 continue to rise, level off, or start to decline? This book describes a concerted, international research effort undertaken with the goal of establishing a database that allows the best possible description of the mortality trajectory beyond the age of 110. The International Database on Longevity (IDL) is the result of this ongoing effort. The IDL contains exhaustive information on validated cases of supercentenarians (people 110 years and older) and allows unbiased estimates of mortality after age 110. The main finding is remarkable: human mortality after age 110 is flat at a probability of death of 50% per year. The sixteen chapters of this book discuss age validation of exceptional longevity, data on supercentenarians in a series of countries, structure and contents of the IDL, and statistical analysis of human mortality after age 110. Several chapters include short accounts of specific supercentenarians that add life to demographic research.

As people live longer and health care costs continue to rise and fewer doctors choose to specialize in geriatrics, how prepared is the United States to care for its sick and elderly? According to veteran psychologist Seymour Sarason's eloquent and compelling new book, the answer is: inadequately at best. And rarely discussed among the grim statistics is the psychosocial price paid by nursing home patients, from loneliness and isolation to depression and dependency.

In "Centers for Ending," Dr. Sarason uses his firsthand experience as both practitioner and patient in senior facilities to reveal wide-ranging professional and moral issues affecting this seemingly familiar terrain. Insensitive medical personnel, poorly trained nurses and aides, indifferent administrators, and a prevailing culture content with treating "bodies" instead of human beings are identified as contributing factors. Drawing on America's rich history of large-scale solutions to social problems, Dr. Sarason offers penetrating insights and bold suggestions in such areas as:

The widening care gap between haves and have-nots.Why professional caregivers fail to understand patients.The nursing home resident as immigrant.Why previous reform efforts have not worked.The need for a Presidential commission for the elderly.The scenario if conditions are allowed to remain as they are or worsen.

This concise volume is essential reading for researchers, graduate students, professionals, practitioners, and policy makers across such fields as geriatric medicine, health psychology, social work, public health, and public policy. "Centers for Ending "is a clarion call to be ignored at great cost to our elders and ourselves. "

"Transitions and the Lifecourse" investigates and challenges dominant interpretations of transitions in late life. Amanda Grenier takes a cross-national and interdisciplinary comparative approach to the topic of aging and the life course, yielding a fresh perspective on these transitions as well as considering some innovative strategies for addressing concerns related to them. Scholars and students interested in social gerontology, policy studies in health and social care, and older people's accounts of lived experience will find this book to be a stimulating read.

This exceptional collection draws on the most recent demographic data and combines classic research with cutting-edge approaches to provide an invaluable overview of the developmental psychology of the adult years. * Covers a wide range of topics within adult development and aging, from theoretical perspectives to specific content areas * Includes newly commissioned essays from the top researchers in the field * Takes a biopsychosocial perspective, covering the biological, psychological and social changes that occur in adulthood

The Upside of Aging: How Long Life Is Changing the World of Health, Work, Innovation, Policy and Purpose explores a titanic shift that will alter every aspect of human existence, from the jobs we hold to the products we buy to the medical care we receive - an aging revolution underway across America and the world. Moving beyond the stereotypes of dependency and decline that have defined older age, The Upside of Aging reveals the vast opportunity and potential of this aging phenomenon, despite significant policy and societal challenges that must be addressed. The book s chapter authors, all prominent thought-leaders, point to a reinvention and reimagination of our older years that have critical implications for people of all ages. With a positive call to action, the book illuminates the upside for health and wellness, work and volunteerism, economic growth, innovation and education. The authors, like the baby boom generation itself, posit new ways of thinking about aging, as longevity and declining birthrates put the world on track for a mature population of unprecedented size and significance. Among topics they examine are: * The emotional intelligence and qualities of the aging brain that science is uncovering, senior moments notwithstanding. * The new worlds of genomics, medicine and technology that are revolutionizing health care and wellness. * The aging population s massive impact on global markets, with enormous profit potential from an explosion in products and services geared toward mature consumers. * New education paradigms to meet the needs and aspirations of older people, and to capitalize on their talents. * The benefits that aging workers and entrepreneurs bring to companies, and the crucial role of older people in philanthropy and society. * Tools and policies to facilitate financial security for longer and more purposeful lives. * Infrastructure and housing changes to create livable cities for all ages, enabling aging in place and continuing civic contribution from millions of older adults. * The opportunities and potential for intergenerational engagement and collaboration. The Upside of Aging defines a future that differs profoundly from the retirement dreams of our parents and grandparents, one that holds promise and power and bears the stamp of a generation that has changed every stage of life through which it has moved.

To begin new relationships in later life is increasingly common in large parts of the Western world. This timely book, part of the Ageing in a Global Context series, addresses the gap in knowledge about late life repartnering and provides a comprehensive map of the changing landscape of late life intimacy.

Memory is essential for the retention of learning. In the presence of memory deficits, new learning is impaired and performance of previously learned habits deteriorates. What is the nature of memory? Where does it reside in the brain? What biological events are associated with the formation and retrieval of memory? These questions are explored in the first chapter of this volume. The answers are not final, but we have learned a great deal about memory processes during the past few decades. Memory is influenced by most of the pathological processes that influ ence the brain such as infection, trauma, cerebrovascular disorders, and met abolic and degenerative diseases. The nature and course of memory impairment are unique for each of the disorders and are fairly distinguishable. More than fifty conditions are known to cause dementia, which now affects several million Americans. In Alzheimer's disease, memory disorder predominates for two to three years before other intellectual functions are affected. Many neurological diseases, such as Huntington's disease, Friedreich's ataxia, and multiple sclerosis, are associated with progressive memory deficits. Forgetting is a problem that becomes progressively worse with age. Most individuals in their forties begin to experience some difficulty in quick recall of past events. By age sixty definite changes are evident in the process of registration, storage, and recall of memory. At this age the material that is to be remembered is processed more slowly, stored less firmly, and poorly recalled."

International contributors apply lifecourse approaches to understanding evolving definitions of work and retirement. They consider the range of transitions from paid work to retirement that are potentially different for women and men in different family circumstances and occupational locations, and offer solutions governments should consider to enable them to evaluate existing policies.

This book is a collection of work on aging and development from authors from the global south. Aging is steadily evolving as a public health and social crisis for which countries of the global south are ill-prepared. The forces of development and improved public health services have ensured that human being live longer. But there is enough evidence that such longevity do not commensurate with good health. As such, many countries of the global south are seeing a booming population who are aging in poor health, without the necessary safety net to ensure quality of life. This book discusses work from Asia, Africa, and South America to explore the challenges facing older adults. Topics include: aging in institutions, living arrangements of older adults, food insecurity, social isolation, end of life migration, and policy papers. This is the first book to bring together varied perspectives on the situation of older adults, and the challenges and opportunities that lie in developing innovative, sustainable programs to support elderly care services.

Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. (c) 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E."

Inverse Projection is a method for estimating accurate demographic indicators of a population where vital registration data are available, but population censuses are lacking or unreliable. The book offers an overview of the present state of methodological development in the field of inverse projection techniques. In the various chapters of the book, leading experts in demography and related fields review the method, discuss recent extensions, test performances, and stress differences of the various procedures. The book is intended for all scientists who are interested in the reconstruction of demographic scenarios in particular situations, with specific kinds of data, as well as for statisticians and mathematicians who are attracted by this fascinating field of application.

The book gives an overview of the implications of population ageing on economic development and financial systems. It describes several challenges which the ageing process poses for central banks, giving special consideration to the situation in Europe. The first two chapters discuss the relationship between ageing and saving and between ageing and international capital flows. Other chapters consider the possible implications for financial markets. The final part raises issues which are of particular relevance for central banks, namely ageing and financial stability and how ageing will affect monetary policy.

Decisions at the End of Life is the last volume in a trilogy on Aging conceived for the International Library of Ethics, Law, and the New Medicine. Leading scholars from a range of disciplines examine some of the most emotive topics in the study of aging: assessing quality of life, improving end-of-life care, palliative care, euthanasia, and consent to research.

Positive conceptions of healthy aging are rightly displacing negative ageist perceptions of older members of our society. Nevertheless, at some stage, most elderly citizens will require some form of assistance from other members of society. When the body or mind begins to fail, a legitimate need for intervention and care will arise. This second volume on Aging discusses this theme.

How should life expectancy be calculated? More generally, how should life - bles be estimated? Since John Graunt's pioneering contribution, read before theRoyalSocietyofLondonat6p. m. onthe27thofFebruary1661, demog- phers have developed better and better methods. Some concerns were raised, including concerns about how to deal with heterogeneous populations p- lished in an article inDemography in 1979 that I wrote with Kenneth Manton and Eric Stallard. Yet, a few years ago nearly all demographers believed that as long as the underlying population and death counts were accurate, then lifetables could be reliably estimated. John Bongaarts and Gri? Feeney launched a revolutionary assault on this dogma. Two key contributions by them are reprinted in Part I of this mo- graph. Some very good demographers agreed, as least in part, with B- gaarts' and Feeney's radical argument that when death rates are changing, then tempo e?ects distort conventional calculations of life expectancy. Other very good demographers disagreed. So John Bongaarts and I brought some leading demographers together in a research meeting, co-sponsored by the Max Planck Institute for Demographic Research and the Population Co- cil and held in New York City on November 18 and 19, 2004. Many of the papers discussed at the workshop, generally after considerable revision, were published in Demographic Research in 2005 and 2006. Nine of these articles, in some cases somewhat revised, are published in this monograph: they are the ?rst seven chapters in Part II and the two chapters in Part III.

This fascinating book examines rural retirement migration from the older in-migrants perspective and from the vantage point of the destination communities to which they move. This integrated approach permits the authors to view older in-migrants as embedded in environments that facilitate and/or constrain their opportunities for productive living during older age. It also permits the examination of positive and negative effects of older in-migration for destination communities."

This book was conceived as a project of the Association for Anthropology and Gerontology, a multidisciplinary and international organization, formed in 1978, that is dedicated to the exploration and understanding of aging within and across the diversity of human cultures. The perspective of the Association is holistic, comparative and international. Membership is drawn from both academic and applied sectors and includes the social and biological sciences, medicine, urban planning, policy studies, social work and the development, administration and provision of services for the aged. Information about membership may be obtained from Dr. Eunice Boyer, Department of Sociology and Anthropology, Carthage College, Kenosha, Wisconsin WI, 53141 USA. Vll ACKNOWLEDGEMENTS In a collective enterprise such as this, there are many people who have helped us along the way. Many members of the Association for Anthropology and Gerontology and many other colleagues gave us advice, read and commented on drafts of papers and otherwise supported this project. The editors and individual authors would like to acknowledge the following for their support and help; Baine B. Alexander, Steve Albert, C. C. Ballew, Diana Bethel, Jacob Climo, Ann Dill, Jean De Rousseau, Nancy Foner, Doris Francis, Mel Goldstein, Ralph Garruto, Tony Glascock, Charlotte Ikels, Sharon Kaufman, Jeanie Kayser-Jones, S. Loth, Mark Luborsky, Linda Mitteness, Corinne Nydegger, J. D. Pearson, David Plath, J. P. Ritchie, Phil Stafford, Rachael Stark, Maria Vesperi, Marjorie Schweitzer, Jay Sokolovsky, Toni Tripp Reimer, Martin Whyte, and Connie Wolfsen. ix ROBERT L."

This volume brings together leading researchers on quality of life in old age to focus on one of the most important issues in both gerontology and quality of life studies. Quality of life is a holistic construct and assessed from many different perspectives and by many disciplines. Moreover, the concept of quality of life can be applied to practically all important domains of life. Thus, quality of life research has to include social, environmental, structural, and health related aspects and be approached from an interdisciplinary perspective. Recently research in gerontology has begun to systematically study quality of life - following the WHO dictum 'years have been added to life and now the challenge is to add life to years' - however there are very few texts available on this topic and none of an international and multi-disciplinary nature. Quality of life studies have neglected older people and, given the size and growth of this population, it is time to publish a volume on this topic that systematically pursues a comprehensive perspective and includes theoretical approaches and empirical findings with respect to the most important components of quality of life in old age. For these reasons and the high quality of the authors we have assembled, this will be a seminal text for both gerontology and quality of life researchers.

Men, Masculinities, and Aging introduces readers to the gendered nature of aging men's lives. Edward H. Thompson, noted for his work on men and aging, explores the intersections of ethnicities, class, geographies, generations, and masculinities. The book offers a fresh perspective on men's experiences with bodily aging, growing older in an ageist society, and navigating the virtual absence of cultural guidelines for being an aging man. The book also provides a sociological theory framework on how men navigate their social aging as they experience later life and very late life. Turning points such as grandfathering, the changeover from work to retirement, and the onset of health problems or becoming a career are discussed at length as Thompson frames these natural occurrences as now ordinary experiences as aging masculinities are no longer rarities. The book will provide educators, students, researchers, and practitioners a means to question standard assumptions about aging men and discuss what underlies most later-life masculinities.

This stimulating, carefully-researched book on The Late Life Legacy of Very Early Life by Dr. Gabriele Doblhammer is the second volume of a new series of Demographic Research Monographs published by Springer Verlag. The topic of the book is fascinating. Is a person's lifespan influ enced by health and nutrition in-utero and shortly after birth? If so, why? The answers uncovered by the diligence, demographic and statistical ex pertise, and probing intelligence of the author are surprising but convinc ing. To pry open the mystery of the lingering impact of very early life, Dr. Doblharnmer focuses on month of birth. It turns out that people born in some months live substantially longer on average than people born in other months, not because of astrological forces but for reasons of health and nutrition. Dr. Doblhammer was educated in statistics and demography and earlier this year was the first person ever to receive the "Habilitation" de gree, the recognition given in the German-speaking world to proven scho lars who are qualified to become professors, in Demography. This book, which is evidence that she fully deserves this award, will not only provide important new fmdings about the legacy of early life but will also serve as a comprehensive foundation of knowledge on which future scholars can build. The series of Demographic Research Monographs is under the editorial supervision of the Max Planck Institute for Demographic Research. Prof. James W. Vaupel, Founding Director of the Institute, is Editor-in-Chief."