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Books > Academic & Education > Professional & Technical > Biomedical Science
Now available in its Third Edition, Asthma: Basic Mechanisms and
Clinical Management has become "the" reference text in asthma. This
highly successful text sheds new light on the basic physiological
and molecular mechanisms of asthma, how current treatments work,
and how best to apply the latest knowledge to control this
important disease. The Third Edition has undergone radical revision
and includes several new chapters. It retains the virtues of the
previous volumes by bringing together all of the recent research
findings by internationally recognized experts on the causative
mechanisms of asthma, including in-depth clinical aspects and
therapy. The book presents an integrated approach toward the
treatment of this disease with new concepts, changes in asthma
management, and the development of new therapeutic agents. Asthma
provides extensive references for researchers and clinicians who
need to keep abreast of recent developments in this rapidly
expanding field.
The use of model organisms together with the power of genetics
has profoundly affected our understanding of the physiology of one
organ, the skeleton, in two distinct but complementary ways. Thisis
the first translational reference to focus on these major
conceptual advances in bone biology and their development in the
clinic. Several advances have already been translated into
therapies and others are being tested for diseases as different as
osteoporosis, type-2 diabetes, and hypo-fertility. This book is a
timely reference for both basic and clinical researchers in bone
biology and endocrinology. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles "
Nutritional oncology is an increasingly active interdisciplinary
field where cancer is investigated as both a systemic and local
disease originating with the changes in the genome and progressing
through a multi-step process which may be influenced at many points
in its natural history by nutritional factors that could impact the
prevention of cancer, the quality of life of cancer patients, and
the risk of cancer recurrence in the rapidly increasing population
of cancer survivors.
Molecular Medicine is the application of genetic or DNA-based
knowledge to the modern practice of medicine. "Molecular Medicine,"
4e, provides contemporary insights into how the genetic revolution
is influencing medical thinking and practice. The new edition
includes recent changes in personalized medicine, new growth in
omics and direct-to-consumer DNA testing, while focusing on
advances in the Human Genomeproject and implications of the
advances in clinical medicine. Graduate students, researchers,
clinicians and allied health professionals will appreciate the
background history and clinical application of up-to-date molecular
advances.
Bioactive Food as Dietary Interventions for Liver and
Gastrointestinal Disease provides valuable insights for those
seeking nutritional treatment options for those suffering from
liver and/or related gastrointestinal disease including Crohn s,
allergies, and colitis among others. Information is presented on a
variety of foods including herbs, fruits, soy and olive oil. This
book serves as a valuable resource for researchers in nutrition,
nephrology, and gastroenterology. * Addresses the most positive results from dietary interventions using bioactive foods to impact diseases of the liver and gastrointestinal system, including reduction of inflammation, improved function, and nutritional efficiency * Presents a wide range of liver and gastrointestinal diseases and provides important information for additional research * Associated information can be used to understand other diseases, which share common etiological pathways"
Bioactive Food as Dietary Interventions for the Aging
Populationpresents scientific evidence of the impact bioactive
foods can have in the prevention and mediation of age related
diseases. Written by experts from around the world, this volume
provides important information that will not only assist in
treatment therapies, but inspire research and new work related to
this area. Important information for developing research on this rapidly growing population representing an increasingly significant financial burden Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases, which share common etiological pathways. "
While diet has long been recognized as having potential to
alleviate symptoms of inflammatory diseases including arthritis,
lupus and fibromyalgia, research indicates that specific foods
offer particular benefits in preventing or mitigating specific
symptoms. Bioactive Food as Dietary Interventions for Arthritis and
Inflammatory Diseases is the only available resource focused on
exploring the latest advances in bioactive food research written
for the scientist or professional audience.
Exposure to space flight has been shown to results in changes in
many physiological systems, including the musculoskeletal system,
the cardiovascular system, the immune system, and the
neurovestibular system. These changes could negatively impact the
ability of humans to undertake long-term habitation and exploration
of space. However, there are limits to the studies that can be done
with humans in space. Both ground-based and space flight animal
model systems are currently used for these studies as an
alternative. This volume covers the latest developments in the use
of animal models to study the effects of the space flight
environment on human physiological systems.
This is a unique book on thyroid neoplasms in that it covers many
current topics in the area including tumor development, tumor
markers and preclinical treatment for advanced cancer as well as
practical approaches (radioiodine, ultrasound, thyroglobulin
monitoring and PET scanning). This book will give the general
reader and specialist a good foundation for what is currently going
on in the area of thyroid neoplasms.
In this volume of ASPA, devoted to developmental biology research,
9 authors from different fields of developmental biology present
their investigations on various developing plant and animal models.
An "a priori" concern in mind that weightlessness might have
negative effects on developmental processes, it is encouraging to
know that the overall development of various organisms tested so
far is essentially correct under spaceflight conditions, leading to
viable individuals with viable offspring. On the other hand,
particular studies on specifically neurophysiological aspects in
developing organisms reveal important flight or postflight
disturbances; however it is encouraging to know that they appear to
be transient only.
For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of
aging? The evidence is overwhelming that the life extension results
from a slowing of aging processes. And the factor responsible is
the decrease in caloric intake. The obvious question: How does this
factor work? A good question - and the reason that research on the
anti-aging action of caloric restriction is today one of the most
studied research areas in biological gerontology. For it is felt
that if the biological mechanisms of the anti-aging action of
caloric restriction can be uncovered, we would gain an
understanding of the basic nature of aging processes, which would,
in turn, yield possible interventions in human aging. This book
aims to provide the growing number of researchers in this field
(faculty, postdoctoral trainees, and graduate students) with a
detailed knowledge of what is known about caloric restriction
within the frame of gerontology, as well as insights on future of
this field.
This volume of "Advances in Cell Aging and Gerontology" provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.
During the past several years there has been a shortage of flight
opportunities for biological and medical projects. And those that
were available usually had severe restrictions on instrumentation,
number of subjects, duration, time allotted for performing the
experiments, a possibility for repetition of experiments. It is our
hope and expectation that this will change once the international
Space Station is in full operation. The advantages of a permanent
space station, already demonstrated by the Russian Mir station, are
continuous availability of expert crew and a wide range of
equipment, possibility of long-term experiments where this is
waranted, increased numbers of subjects through larger laboratory
space, proper controls in the large 1-G centrifuge, easier
repeatability of experiments when needed.
Breast cancer research has never been in such an exciting and
hopeful phase as today. From a clinical perspective, the discovery
of genetic markers of risk in a proportion of familial breast
cancer cases has opened up new vistas for understanding and
ultimately preventing this disease. On the other hand, aggressive -
even daring - therapies are being proven to be effective against
advanced breast cancer. For the breast cancer experimentalist, this
is also a time of great advance. Although animal and cell culture
breast cancer models have proven to be of great use, there are now
increasing opportunities to test the concepts developed in these
models in actual clinical samples and cases. It is gratifying to
see how well these concepts "translate" into the clinical setting.
A very active area of research that is linking the laboratory to
the clinic is the dissection of the biology and elucidation of the
significance of proliferate breast disease and the identification
of true, "high risk" or "preneoplastic" legions within the
previously ill-defined spectrum of fibrocystic or benign breast
disease. One anticipates that discoveries made here will also lead
to earlier detection, intervention and prevention of
life-threatening cancer.
The present volume is the first in the advances in oncobiology series. It is meant to be useful not only to clinical and non-clinical oncologists but also to graduate students and medical students. The individual chapters are presented as self-contained summaries of current knowledge rather than as reviews. The last chapter deals with the subject of chemotherapy.
This volume is intended to complete the Cell Chemistry and
physiology module. It is about how the traditional boundaries of
cell chemistry and physiology are being erased by molecular
biology. We do not think it necessary to elaborate on this theme,
particularly since the body of core knowledge found in this volume
brings us a stage closer to answering the question, "what makes
cell biology into a new discipline?"
This volume illustrates the extent to which the traditional
distinction between biochemical and physiological processes is
being obliterated by molecular biology. It can hardly be doubted
that the revolution in cell and molecular biology is leading to
core knowledge that provides an outline of the integrative and
reductionist approach. We view this as the beginning of a new era,
that of the integration of learning.
This is the first of a 4-volume module that is an introduction to
the study of cell chemistry and physiology. It is not intended to
be encyclopedic in nature but rather a general survey of the
subject with an emphasis on those topics that are central to an
understanding of cell biology and those that are certain to become
of increasing importance in the teaching of modern medicine.
This fourth volume in the series, dedicated entirely to the results
of the first European study of the effects of long-term confinement
and isolation. The volume continues to attempt to fulfill the aim
of this series, to bring the findings and accomplishments in the
field of space biology and medicine to a wider group of scientists
than merely the relatively small group of biologists and
physiologists currently involved in space experimentation.
A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. Individuals active in muscle investigation--as well as those new
to the field--will find this work useful, as will students of
muscle biology. In the case of hte former, many wish to grasp
issues at the margins of their own expertise (e.g. clinical matters
at one end; molecular matters at the other), adn this book is
designed to assist them. Students, postdoctoral fellows, course
directors and other faculty will find this book of interest. Beyond
this, many clinicians in training (e.g. cardiology fellows) will
benefit.
Cancer continues to be one of the major causes of death
throughout the developed world, which has led to increased research
on effective treatments. Because of this, in the past decade, rapid
progress in the field of cancer treatment has been seen. "Recent
Advances in Cancer Research and Therapy" reviews in specific
details some of the most effective and promising treatments
developed in research centers worldwide. While referencing advances
in traditional therapies and treatments such as chemotherapy, this
book also highlights advances in biotherapy including research
using Interferon and Super Interferon, HecI based and liposome
based therapy, gene therapy, and p53 based cancer therapy. There is
also a discussion of current cancer research in China including
traditional Chinese medicine. Written by leading scientists in the
field, this book provides an essential insight into the current
state of cancer therapy and treatment.
Understanding the complex factors contributing to the growing
childhood obesity epidemic is vital not only for the improved
health of the world's future generations, but for the healthcare
system. The impact of childhood obesity reaches beyond the
individual family and into the public arenas of social systems and
government policy and programs. "Global Perspectives on Childhood
Obesity" explores these with an approach that considers the current
state of childhood obesity around the world as well as future
projections, the most highly cited factors contributing to
childhood obesity, what it means for the future both for children
and society, and suggestions for steps to address and potentially
prevent childhood obesity.
The field of gender-specific medicine examines how normal human
biology and physiology differs between men and women and how the
diagnosis and treatment of disease differs as a function of gender.
This revealing research covers various conditions that
predominantly occur in men as well conditions that predominantly
occur in women. Among the areas of greatest difference are
cardiovascular disease, mood disorders, the immune system, lung
cancer as a consequence of smoking, osteoporosis, diabetes,
obesity, and infectious diseases. Longer bibliographies and suggested reviews/papers of particular relevance and importance will be added at the end of each section. Each author will be asked to include recent meta-analysis of data Each chapter will progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments Section on drug metabolism will be eliminated but the subject will be incorporated into each relevant chapter Section on aging will be eliminated but age will be considered as a variable in each of the separate chapters "
The Liver in Biology and Disease was conceived as a sequel in the
series "Principles of Medical Biology," whose general aim continues
to be the integration of human biology and molecular cell biology
into modern molecular medicine. It is a volume molded by the
Information Revolution which few will deny has forced the teaching
faculties in our medical schools to curtail and prune the teaching
load and focus on fundamentals and principles. With this intention
in mind, a volume of this nature takes into account the close
dependence of progress in the medical sciences on bioinformatics
(gene and protein analysis) or more precisely, computational
biology and of course, the Internet. In general, it follows the
pattern of its predecessors.
Molecular Endocrinology, Third Edition summarizes the area and
provides an in-depth discussion of the molecular aspects of hormone
action, including hormone-receptor interactions, second messenger
generation, gene induction, and post-transcriptional control.
Thoroughly revised and updated, the Third Edition includes new
information on growth factors hematopoietic-immune factors,
nonclassical hormones, receptors, transduction, transcriptional
regulation, as well as other relevant topics. Incorporating an
abundance of new information, this text retains the self-contained,
focused, and easily readable style of the Second Edition. |
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