Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic.

The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodologoy related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.
* Presents comprehensive reviews covering all aspects of drug development and formulation of drugs
* Now encompassing critical review chapters
* Meets the information needs of the drug development community

Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.
High quality comprehensive reviews covering all aspects of carbohydrate chemistry

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, and chemistry. With invited reviews written by leading international researchers, as well as regular thematic issues, each volume presents new results and provides a single vehicle for following progress in this interdisciplinary area.
Volume 47 is a tribute in honor of Professor Osvaldo Goscinski. The volume will look at the accomplishments of a man who has led a remarkable development within the field and developed and strengthened scientific networks in Quantum Chemistry and Chemical Physics.
* Provides a tribute in honor of Professor Osvaldo Goscinski, a man who has led a remarkable development within the field

Advances in Inorganic Chemistry presents timely, informative and comprehensive reviews of the current progress in all areas within inorganic chemistry ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.
. The latest volume in this highly successful series is dedicated to redox-active metal complexes
. Comprehensive reviews written by leading experts in the field
. An indispensable reference to advanced researchers

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, and chemistry. With invited reviews written by leading international researchers, as well as regular thematic issues, each volume presents new results and provides a single vehicle for following progress in this interdisciplinary area.
The intention of this volume, as with the previous volume in this series is to present the latest developments in the field of energy deposition as it is actually viewed by many of the major researchers working in this area. It is not possible to incorporate all of the important players and all of the topics related to energy deposition in the limited space available; however the editors have tried to present the state of the art as it is now.

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.

The intention of this and the next volume in this series is to present the latest developments in the field of energy deposition as it is actually viewed by many of the major researchers working in this area. It is hard to incorporate all of the important players and all of the topics related to energy deposition in the limited space available; however the editors have tried to present the state of the art as it is now.
- High quality and thorough reviews of various aspects of quantum chemistry

This latest volume in the Advances in Chemical Engineering series, is a contemporary analysis of the preparation, structure and properties of
biomaterials with emphasis on the molecular design and material/polymer
interactions. The book addresses cell-biomaterials adhesion,
biomaterials and gene therapy, protein adsorption, platelet and white
cell activation processes, molecular design and surface modification of
novel biomaterials.
- Original reviews
- Leading chemical engineers as authors
- Update on biomaterials use
- Novel subject on use of biomaterials in drug delivery and gene therapy
- Mathematical modeling

Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.
Provides an authoritative, definitive review addressing all aspects of organometallic chemistry.
Useful to all researchers within this active field and is a must for every modern library of chemistry.
High quality research book within this rapidly developing field.

Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry ranging from bio-inorganic to solid state studies. Thisacclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.
. Comprehensive reviews written by leading experts in the field
. An indispensable reference to advanced researchers
. Includes 7 contributions covering important advances in inorganic chemistry

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area, one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.
. Provides an authoritative, definitive review addressing all aspects of organometallic chemistry.
. Useful to all researchers within this active field and is a must for every modern library of chemistry.
. High quality research book within this rapidly developing field.

Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

High quality comprehensive reviews covering all aspects of carbohydrate chemistry.

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.
- High quality and thorough reviews of various aspects of quantum chemistry

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.
- High quality and thorough reviews of various aspects of quantum chemistry

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Comprehensive reviews of topics in heterocyclic chemistry.
Subject of importance to organic chemists in academia and industry, to biologists and biochemists and all scientists in related scientific areas.
Authors are established authorities in their subjects."

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than forty years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.
Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective.
Comprehensive dynamic reviews written by the leading authors in the respective fields.
Broader coverage than before on the biological aspects.

Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. This widely acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964.
Volume 49 provides an authorititative, definitive review addressing all aspects of organometallic chemistry.
Useful to all researchers within this active field and is a must for every modern library of chemistry.
High quality research book within this active field.

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.

Advances in Quantum Chemistry presents surveys of current developments in this rapidly developing field that falls between the historically established areas of mathematics, physics, chemistry, and biology. With invited reviews written by leading international researchers, each presenting new results, it provides a single vehicle for following progress in this interdisciplinary area.

This series is world-renowned as the leading compilation of current reviews of this vast field.
Internationally acclaimed for more than forty years, The Alkaloids: Chemistry and Biology, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, and various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.
This, the 58th volume in the series presents two quite different aspects of alkaloids. The first of the two chapters reviews the substantial progress made on the biotransformations of various classes of alkaloids and examines the enzymes systems involved in this process. Such studies are proving very important in the consideration of how alkaloids can be used in the future as medicinal or biological agents. The second chapter presents a comprehensive review of the known polyamine alkaloids based on their biogenesis and additionally provides overviews of their detailed structural analysis, their synthesis, biosynthesis and biology.
* The 58th volume in this series of essential reference works
* Written by leading experts in the field
* An essential research tool for anyone working with alkaloids in chemistry or biology

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than forty years, "The Alkaloids: Chemistry and Biology," founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.
This latest volume comprehensively reviews the recent progress of two classes of alkaloid, the C20 diterpene alkaloid and the iboga alkaloid. The former are examined in terms of their classification, distribution and occurence as well as their spectroscopic aspects, biological activities and the determination of stereochemistry. The later are seen through the perspectives of isolation, structure determination and synthesis and additonally reviewed in terms of their involvement in the formation of the natural and semi-synthetic bisindole alkaloids from "Catharanthus."
. The latest volume in this series of indispensable texts
. Written by leading experts in the field
. An essential reference tool for anyone working with alkaloids in chemistry or biology

Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances and Excipients, brings the latest information together in one source.
.Represents a very important contribution to the practice of pharmaceutical analysis
.Presents an excellent overview of physical, chemical, and biomedical properties of some regularly prescribed drugs
.Each volume in the series contains a cumulative index

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.
.Comprehensive reviews of topics in heterocyclic chemistry
.Subject of importance to organic chemists in academia and industry, and to scientists in many fields
.Authors are established authorities in their subjects

Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bioinorganic to solid state.
Importance of Topic
Inorganic chemistry deals with the chemistry of the elements.
As such it is of interest to chemists, materials scientists and molecular
biologists
Why This Title
This acclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced. This series was cited 1,972 times in 2000 by the journals covered by ISI. ISI impact factor in 2000: 11.54
Praise for the Series
"These ... volumes continue the tradition of representing timely summaries of the current state of understanding on a wide variety of 'special topics'... These volumes provide much useful information and are quite well written." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY