Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a 'must' for researchers and students wishing to stay up-to-date on current developments in computational chemistry.
In Volume 3, topics covered include Simulation Methodologies (Carlos Simmerling), Biological and Biophysical Applications (Heather Carlson), Chemical Education (Theresa Zielinski), Materials and Polymers (Jeffry Madura), Quantum Chemistry (T. Daniel Crawford), and Emerging Technologies (Wendy Cornell). With this volume we extend the practice of cumulative indexing of both the current and past editions in order to provide easy identification of past reports.
* Broad coverage of computational chemistry and up-to-date information
* Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

Novel asymmetric synthetic methods are a vital strategem in the armoury of the organic chemist, particularly for those involved in the preparation or application of chiral organic molecules. this series is devoted to presenting the latest advances in the field of asymmetric synthesis, drawing contributions on emerging areas and articles providing authoritative perspectives on more developed synthetic stategies from leading researchers in the field. This volume consists of six contributions on a variety of topical areas, ranging from the preparation and application of chiral cylopentadienes, the synthesis of non-racemic amines, diketones and -keto esters and ferrocenes, to the use of biocatalysis and application of microbial methods for the synthesis of chiral molecules and fine chemicals.

Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the "Thalictrum" alkaloids. Forty-six new alkaloids are described from fifteen species of the genus "Thalictrum," as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the "Thalictrum" alkaloids.

Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: "Taxus"). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.

Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized.

Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related "nor"tropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing.

Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

This volume presents a variety of articles that encompass the broad scope of supramolecular chemistry. Reusch's chapter covers biological channel compounds, while the work of Hall and Kirkovits looks into their synthetic counterparts. Metal ion sensors, calixarenes and "crystal engineering" are described by pioneers in these fields. This work, whilst current and authoritative, shows us that much remains to be undertaken and understood. It is hoped that this volume will be of interest to those who wish to fill these gaps; scientists already in the field and those who may see extensions of their own work that will bring them into it.

The series "Advances in Dendritic Macromolecules" aims to cover the synthesis and supramolecular chemistry of dendritic or cascade super-molecules as well as their less perfect hyperbranched cousins.
In Volume 3, Chapter 1 describes the synthesis and characterization of dendrimers and hyperbranched polyesters, both based on 2,2-bis(hydroxymethyl)propionic acid, as the AB2-monomer. Chapter 2, discusses the advantages and drawbacks of dendritic molecular architectures necessary to create polymeric organic magnetic materials. In Chapter 3, Balzani and colleagues delineate their contributions to the field of polynuclear transition metal complexes in the design and construction of dendritic nanostructures; these luminesence and redox-active complexes suggest their role as photochemical molecular devices operating by photoinduced energy and electron transfer processes. Chapter 4, reviews the overall progress on redox-active dendrimers, especially as redox catalysts, organic conductors, modified electrodes, and models for electron transfer proteins. Chapter 5, summarizes the pioneering research in organometallic dendritic macromolecules and then delineates the redox properties of a series of silicon-based ferrocenyl-containing dendrimers.

Volume 14 of this series presents three interesting reviews of research on alkaloids. Chapter 1, by Paul L. Schiff, Jr., is a monumental effort, presenting a selective, comprehensive tabular review of research on the bisbenzylisoquinoline alkaloids, with an analysis of the respective alkaloid types. The chapter should serve as a very useful tool for the bench research scientist who is involved in the isolation and elucidation of structures of bisbenzylisoquinoline alkaloids. Moreover, the data in these tables provides the botanical distribution and occurrence (family, genus, species) of the various classes of these alkaloids. The alkaloids are also categorized by their molecular weights and structural types.
Chapter 2, by Toh-Seok Kam, is a review of alkaloids derived from Malaysian flora. Malaysia's position near the Equator confers on it a tropical climate characterized by high temperatures, humidity, and rainfall, conditions favorable for plant life that has resulted in a rich flora of about 15,000 species of higher plants. This review concentrates on work published during the past twenty years and where appropriate compares the occurrence of alkaloids with studies of similar plants from countries neighboring to Malaysia, especially Thailand and Indonesia.
Chapter 3, by Jie Jack Li, presents a collection of very interesting total syntheses of naturally occurring indole alkaloids where palladium chemistry plays a central role in the syntheses. Five different types of palladium-mediated reactions are treated: (1) oxidative cyclization reactions promoted by palladium (II) species; (2) transmetallation reactions with organoboranes, organostannanes, and organozinc reagents; (3)inter- and intramolecular Heck reactions; (4) reactions with &pgr; -allylpalladium as the intermediate; and (5) reactions using C-N bond formation as the key step for the synthesis.

"Annual Reports in Computational Chemistry" is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. "Annual Reports in Computational Chemistry" is a "must" for researchers and students wishing to stay up-to-date on current developments in computational chemistry.
* Broad coverage of computational chemistry and up-to-date information
* Topics covered include bioinformatics, drug discovery, protein NMR, simulation methodologies, and applications in academic and industrial settings
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

This fourth volume in the series "Organic Synthesis: Theory and Applications" is composed of five chapters that span a wide range of disciplines. Alkaloid chemistry, total synthesis, synthetic methodology, carbohydrate technology, and spin-trapping agents are all covered by experts in these fields.
The first chapter is one of the finest examples of deductive reasoning in the chemical literature, examining the rich history of the chemistry of morphine. Within the following chapters, synthetic challenges of the marine terpenoids are brought into focus, the chemistry and synthetic applications of cyclobutenediones are reviewed and the utility of glycosyl iodides in the preparation of glycosides are summarized. Finally a report on a new class of spin-traping agents, azulenyl nitrones is covered. In all, five diverse subdisciplines are brought together and reviewed in this volume.

Beginning as chemical curiosities, carbenes are now solidly established as reactive intermediates with fascinating and productive research areas of their own. Five decades of divalent carbon chemistry have provided us with a vast repertoire of new, unusual and surprising reactions. Some of those reactions, once classified as exotic, have become standard methods in organic synthesis. These highly reactive carbene species have been harnessed and put to work to achieve difficult synthetic tasks that other reactive intermediates cannot easily perform.
The fruitful relationship between experiment and theory has pushed carbene chemistry further toward the direction of reaction control; that is, regio- and stereoselectivity in intra- and intermolecular addition and insertion reactions. The interplay between experiment and modern spectroscopy has led to the characterisation of many carbenes that are crucial to both an understanding and a further development of this field.
Understanding of carbene chemistry has advanced dramatically, especially in the last decade, and new developments continue to emerge. Some of the recent exciting findings have been collected in the first volume of "Advances in Carbene Chemistry." With this second volume, the series will continue to provide a periodic coverage of carbene chemistry in its broadest sense - leading into the next century.

Part of a series which covers areas of organic synthesis ranging from the latest developments in enantioselective methodologies, to reviews of updated chemical methods. The volumes are written by experts, who describe their own area of expertise, as well as those of their peers.

Gas phase ion chemistry is a broad field that has many applications and which encompasses various branches of chemistry and physics. "Advances in Gas Phase Ion Chemistry, Volume 4, " describes innovative ways of studying reactions as well as the application of unique apparatuses to problems in this field. This volume contains a series of chapters, in the general area of gas phase chemistry and physics, which are at the cutting edge of research.
The chapters are not meant to be general reviews, but focus on the author's own work. They focus on both experimental and theoretical work, which gives a balance to the volume. Applications are included to appeal to a wider audience and to broaden the knowledge of the more fundamentally inclined. An application to environmental pollution monitoring and medical monitoring of breath is included. With successive volumes, the coverage broadens to include more current research in the title area.
The book is aimed at graduate researchers, university faculty and graduates in industry. The editors have made a specific effort to include contributions from those relatively new to the field, which brings in new ideas and perspectives, as well as those more established workers, who bring a wealth of experience.

Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a 'must' for researchers and students wishing to stay up-to-date on current developments in computational chemistry.
* Broad coverage of computational chemistry and up-to-date information
* The topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

"Alkaloids: Chemical and Biological Perspectives," the 15th volume of the ACBP series, features four important reviews of research on alkaloids. Chapter 1 is the first comprehensive review of the carbon-13 and proton NMR shift assignments and physical constants of diterpene alkaloids and their derivatives. In addition to the catalogue of spectral and physical data, the chapter includes a table of the occurrences of these alkaloids in various plant species, tables containing molecular formulas versus calculated high-resolution mass values, and calculated high-resolution mass values versus the molecular formulas of diterpenoid alkaloids, as well as seven tables summarizing the carbon-13 chemical shifts of various functional groups in diterpenoid alkaloids.
Chapter 2 is a fascinating review of the supercritical fluid extraction of alkaloids. This technique using basic modifiers, provides an alternative method for the extraction of alkaloids.
Chapter 3 summarizes recent advances in the synthesis of "Amaryllidaceae" alkaloids, an important class of naturally-occurring bases and neutral compounds. The increased activity in the synthesis of these alkaloids over the last decade is undoubtedly due to the fact that certain members of this family possess interesting and useful biological properties. Elegant syntheses, chiral and otherwise, of structures incorporating many asymmetric centres are reviewed.
Chapter 4 reviews radical cyclization reactions in the total synthesis of indole alkaloids. The use of free radical chemistry in the synthesis of alkaloids has grown markedly because of the mild reaction conditions, tolerance of a wide variety of functional groups, and the good stereoselectivities.
Each chapter in this volume has been reviewed by at least one specialist in the field.

In recent years the most significant advances in carbohydrate research have been made in the knowledge of the structure and function of carbohydrates in the macromolecular state. This title addresses those areas of the subject in which the authors believe the most important work is being carried out.

This series is designed to provide a vehicle in which investigators, who have demonstrated a high degree of competence in some aspect of free radical chemistry, can present a particular area of interest. The series encompasses a wide variety of topics which are of current interest.

Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a 'must' for researchers and students wishing to stay up-to-date on current developments in computational chemistry.
* Broad coverage of computational chemistry and up-to-date information
* The topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

It is clear that electron transfer chemisty is now one of the most active areas of chemical study. "Advances in Electron Transfer Chemistry" has been designed to allow scientists who are developing new knowledge in this rapidly expanding area to describe their most recent research findings. This volume will serve those interested in learning about current breakthroughs in this rapidly expanding area of chemical research.

The object of this series is to provide interesting and timely reviews covering all aspects of the field. It is our hope that this will encourage the transfer of new methods, techniques, and parameterizations from the field in which they were developed to other areas that can make good use of them.
.Quantitative Structure Property Relationships (QSPR) have developed into a major method of chemical research in many scientific disciplines
.Provides much needed cross fertilization between disciplines researching QSPR

Enantioselective synthetic methods are not only in the forefront of chemical and pharmaceutical research but activity in this area is constantly increasing. It is stimulated by the urgency to obtain drugs or compounds of medicinal interest as single anantiomers, and the keeness to synthesize natural products in nonracemic form. This volume presents seven chapters from pioneers and authorities in this rapidly expanding field.

Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.
Solanum alkaloids were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically updates earlier reviews.
In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide alkaloids have been isolated from ascidians, sea hares, and cyanobacteria.
Also included are reviews of the use of the functionalized lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids.
The second review examines the on-line coupling of capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures.
Finally a review of oxygenated analogs of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work.
Each chapter in this volume has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.

The aim of this series is to provide authoritative reviews in the rapidly expanding area of bioinorganic chemistry. The series will present "state of the art" reviews covering the whole field of bioinorganic chemistry.
The present volume is the fourth in the series and covers the topics: lithium in biology, the structure and function of ceroplasmin, rhenium complexes in nuclear medicine, the anti-HIV activity of macrocyclic polyamines and their metal complexes for dinuclear phosphoesterase enzymes.

Annual Reports in Computational Chemistry provides timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists.

"Annual Reports in Computational Chemistry" provides timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists.

This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, "The Alkaloids," founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.
Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective.
Comprehensive, dynamic reviews written by leading authors in the respective fields.
Broad coverage on the biological aspects.

Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on thetheory of heavy ion physics in medicine.
Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on thetheory of heavy ion physics in medicine."