Systems biology came about as growing numbers of engineers and scientists from other fields created algorithms which supported the analysis of biological data in incredible quantities. Whereas biologists of the past had been forced to study one item or aspect at a time, due to technical and biological limitations, it suddenly became possible to study biological phenomena within their natural contexts. This interdisciplinary field offers a holistic approach to interpreting these processes, and has been responsible for some of the most important developments in the science of human health and environmental sustainability. This Very Short Introduction outlines the exciting processes and possibilities in the new field of systems biology. Eberhard O. Voit describes how it enabled us to learn how intricately the expression of every gene is controlled, how signaling systems keep organisms running smoothly, and how complicated even the simplest cells are. He explores what this field is about, why it is needed, and how it will affect our understanding of life, particularly in the areas of personalized medicine, drug development, food and energy production, and sustainable stewardship of our environments. Throughout he considers how new tools are being provided from the fields of mathematics, computer science, engineering, physics, and chemistry to grasp the complexity of the countless interacting processes in cells which would overwhelm the cognitive and analytical capabilities of the human mind. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

The idea of complex numbers dates back at least 300 years-to Gauss and Euler, among others. Today complex analysis is a central part of modern analytical thinking. It is used in engineering, physics, mathematics, astrophysics, and many other fields. It provides powerful tools for doing mathematical analysis, and often yields pleasing and unanticipated answers. This book makes the subject of complex analysis accessible to a broad audience. The complex numbers are a somewhat mysterious number system that seems to come out of the blue. It is important for students to see that this is really a very concrete set of objects that has very concrete and meaningful applications. Features: This new edition is a substantial rewrite, focusing on the accessibility, applied, and visual aspect of complex analysis This book has an exceptionally large number of examples and a large number of figures. The topic is presented as a natural outgrowth of the calculus. It is not a new language, or a new way of thinking. Incisive applications appear throughout the book. Partial differential equations are used as a unifying theme.

Vast holdings and assessment of consumer data by large companies are not new phenomena. Firms' ability to leverage the data to reach customers in targeted campaigns and gain market share is, and on an unprecedented scale. Major companies have moved from serving as data or inventory storehouses, suppliers, and exchange mechanisms to monetizing their data and expanding the products they offer. Such changes have implications for both firms and consumers in the coming years. In Success with Big Data, Russell Walker investigates the use of internal Big Data to stimulate innovations for operational effectiveness, and the ways in which external Big Data is developed for gauging, or even prompting, customer buying decisions. Walker examines the nature of Big Data, the novel measures they create for market activity, and the payoffs they can offer from the connectedness of the business and social world. With case studies from Apple, Netflix, Google, and Amazon, Walker both explores the market transformations that are changing perceptions of Big Data, and provides a framework for assessing and evaluating Big Data. Although the world appears to be moving toward a marketplace where consumers will be able to "pull" offers from firms, rather than simply receiving offers, Walker observes that such changes will require careful consideration of legal and unspoken business practices as they affect consumer privacy. Rigorous and meticulous, Success with Big Data is a valuable resource for graduate students and professionals with an interest in Big Data, digital platforms, and analytics.

Complex analysis is a classic and central area of mathematics, which is studies and exploited in a range of important fields, from number theory to engineering. Introduction to Complex Analysis was first published in 1985, and for this much-awaited second edition the text has been considerably expanded, while retaining the style of the original. More detailed presentation is given of elementary topics, to reflect the knowledge base of current students. Exercise sets have been substantially revised and enlarged, with carefully graded exercises at the end of each chapter.

This book presents the probabilistic methods around Hardy martingales for an audience interested in their applications to complex, harmonic, and functional analysis. Building on work of Bourgain, Garling, Jones, Maurey, Pisier, and Varopoulos, it discusses in detail those martingale spaces that reflect characteristic qualities of complex analytic functions. Its particular themes are holomorphic random variables on Wiener space, and Hardy martingales on the infinite torus product, and numerous deep applications to the geometry and classification of complex Banach spaces, e.g., the SL estimates for Doob's projection operator, the embedding of L1 into L1/H1, the isomorphic classification theorem for the polydisk algebras, or the real variables characterization of Banach spaces with the analytic Radon Nikodym property. Due to the inclusion of key background material on stochastic analysis and Banach space theory, it's suitable for a wide spectrum of researchers and graduate students working in classical and functional analysis.

Since the early eighteenth century, the theory of networks and graphs has matured into an indispensable tool for describing countless real-world phenomena. However, the study of large-scale features of a network often requires unrealistic limits, such as taking the network size to infinity or assuming a continuum. These asymptotic and analytic approaches can significantly diverge from real or simulated networks when applied at the finite scales of real-world applications. This book offers an approach to overcoming these limitations by introducing operator graph theory, an exact, non-asymptotic set of tools combining graph theory with operator calculus. The book is intended for mathematicians, physicists, and other scientists interested in discrete finite systems and their graph-theoretical description, and in delineating the abstract algebraic structures that characterise such systems. All the necessary background on graph theory and operator calculus is included for readers to understand the potential applications of operator graph theory.

A theory of generalized Cauchy-Riemann systems with polar singularities of order not less than one is presented and its application to study of infinitesimal bending of surfaces having positive curvature and an isolated flat point is given. The book contains results of investigations obtained by the author and his collaborators.

Second Order Differential Equations presents a classical piece of theory concerning hypergeometric special functions as solutions of second-order linear differential equations. The theory is presented in an entirely self-contained way, starting with an introduction of the solution of the second-order differential equations and then focusingon the systematic treatment and classification of these solutions. Each chapter contains a set of problems which help reinforce the theory. Some of the preliminaries are covered in appendices at the end of the book, one of which provides an introduction to Poincare-Perron theory, and the appendix also contains a new way of analyzing the asymptomatic behavior of solutions of differential equations. This textbook is appropriate for advanced undergraduate and graduate students in Mathematics, Physics, and Engineering interested in Ordinary and Partial Differntial Equations. A solutions manual is available online.

In the summer of 1970, Georges Matheron, the father of geostatistics, presented a series of lectures at the Centre de Morphologie Mathmatique in France. These lectures would go on to become Matheron's Theory of Regionalized Variables, a seminal work that would inspire hundreds of papers and become the bedrock of numerous theses and books on the topic; however, despite their importance, the notes were never formally published. In this volume, Matheron's influential work is presented as a published book for the first time. Originally translated into English by Charles Huijbregts, and carefully curated here, this book stays faithful to Matheron's original notes. The text has been ordered with a common structure, and equations and figures have been redrawn and numbered sequentially for ease of reference. While not containing any mathematical technicalities or case studies, the reader is invited to wonder about the physical meaning of the notions Matheron deals with. When Matheron wrote them, he considered the theory of linear geostatistics complete and the book his final one on the subject; however, this end for Matheron has been the starting point for most geostatisticians.

This unique two-volume set presents the subjects of stochastic processes, information theory, and Lie groups in a unified setting, thereby building bridges between fields that are rarely studied by the same individuals. Unlike the many excellent formal treatments available for each of these subjects individually, the emphasis in both of these volumes is on the use of stochastic, geometric, and group-theoretic concepts in the modeling of physical phenomena.

Stochastic Models, Information Theory, and Lie Groups will be of interest to advanced undergraduate and graduate students, researchers, and practitioners working in applied mathematics, the physical sciences, and engineering. Extensive exercises and motivating examples make the work suitable as a textbook for use in courses that emphasize applied stochastic processes or differential geometry.

Without an introduction, this volume of 19 papers plunges right into the subject matter presented at the June 1998 symposium held at Bayreuth U. in Bayreuth, Germany. A sampling of topics: almost-lines and quasi-lines on projective manifolds, the classification of K3 surfaces with nine cusps, simply connected Godeaux surfaces, Kahlerian structures on symplectic reductions, and A geometric proof of Ax' theorem. One paper is in untranslated French. Includes an essay on Michael Schneider's scientific work with a publications list (including his still standard reference on vector bundles on projective spaces); a photograph and "alpine" vita of Schneider (who died while sports-climbing in 1997); a list of the eight symposium lectures; and a listing of the authors and participants with contact information. Lacks an index.

This book describes recent developments as well as some classical results regarding holomorphic mappings. The book starts with a brief survey of the theory of semigroups of linear operators including the Hille-Yosida and the Lumer-Phillips theorems. The numerical range and the spectrum of closed densely defined linear operators are then discussed in more detail and an overview of ergodic theory is presented. The analytic extension of semigroups of linear operators is also discussed. The recent study of the numerical range of composition operators on the unit disk is mentioned. Then, the basic notions and facts in infinite dimensional holomorphy and hyperbolic geometry in Banach and Hilbert spaces are presented, L. A. Harris' theory of the numerical range of holomorphic mappings is generalized, and the main properties of the so-called quasi-dissipative mappings and their growth estimates are studied. In addition, geometric and quantitative analytic aspects of fixed point theory are discussed. A special chapter is devoted to applications of the numerical range to diverse geometric and analytic problems.

This book provides the latest competing research results on non-commutative harmonic analysis on homogeneous spaces with many applications. It also includes the most recent developments on other areas of mathematics including algebra and geometry. Lie group representation theory and harmonic analysis on Lie groups and on their homogeneous spaces form a significant and important area of mathematical research. These areas are interrelated with various other mathematical fields such as number theory, algebraic geometry, differential geometry, operator algebra, partial differential equations and mathematical physics. Keeping up with the fast development of this exciting area of research, Ali Baklouti (University of Sfax) and Takaaki Nomura (Kyushu University) launched a series of seminars on the topic, the first of which took place on November 2009 in Kerkennah Islands, the second in Sousse on December 2011, and the third in Hammamet on December 2013. The last seminar, which took place December 18th to 23rd 2015 in Monastir, Tunisia, has promoted further research in all the fields where the main focus was in the area of Analysis, algebra and geometry and on topics of joint collaboration of many teams in several corners. Many experts from both countries have been involved.

The series is aimed specifically at publishing peer reviewed reviews and contributions presented at workshops and conferences. Each volume is associated with a particular conference, symposium or workshop. These events cover various topics within pure and applied mathematics and provide up-to-date coverage of new developments, methods and applications.

In the spring of 1976, George Andrews of Pennsylvania State University visited the library at Trinity College, Cambridge, to examine the papers of the late G.N. Watson. Among these papers, Andrews discovered a sheaf of 138 pages in the handwriting of Srinivasa Ramanujan. This manuscript was soon designated, "Ramanujan's lost notebook." Its discovery has frequently been deemed the mathematical equivalent of finding Beethoven's tenth symphony. This fifth and final installment of the authors' examination of Ramanujan's lost notebook focuses on the mock theta functions first introduced in Ramanujan's famous Last Letter. This volume proves all of the assertions about mock theta functions in the lost notebook and in the Last Letter, particularly the celebrated mock theta conjectures. Other topics feature Ramanujan's many elegant Euler products and the remaining entries on continued fractions not discussed in the preceding volumes. Review from the second volume:"Fans of Ramanujan's mathematics are sure to be delighted by this book. While some of the content is taken directly from published papers, most chapters contain new material and some previously published proofs have been improved. Many entries are just begging for further study and will undoubtedly be inspiring research for decades to come. The next installment in this series is eagerly awaited."- MathSciNet Review from the first volume:"Andrews and Berndt are to be congratulated on the job they are doing. This is the first step...on the way to an understanding of the work of the genius Ramanujan. It should act as an inspiration to future generations of mathematicians to tackle a job that will never be complete."- Gazette of the Australian Mathematical Society

This book is an in-depth and modern presentation of important classical results in complex analysis and is suitable for a first course on the topic, as taught by the authors at several universities. The level of difficulty of the material increases gradually from chapter to chapter, and each chapter contains many exercises with solutions and applications of the results, with the particular goal of showcasing a variety of solution techniques.

This text covers Riemann surface theory from elementary aspects to the fontiers of current research. Open and closed surfaces are treated with emphasis on the compact case, while basic tools are developed to describe the analytic, geometric, and algebraic properties of Riemann surfaces and the associated Abelian varities. Topics covered include existence of meromorphic functions, the Riemann-Roch theorem, Abel's theorem, the Jacobi inversion problem, Noether's theorem, and the Riemann vanishing theorem. A complete treatment of the uniformization of Riemann sufaces via Fuchsian groups, including branched coverings, is presented, as are alternate proofs for the most important results, showing the diversity of approaches to the subject. Of interest not only to pure mathematicians, but also to physicists interested in string theory and related topics.

This volume brings together recent, original research and survey articles by leading experts in several fields that include singularity theory, algebraic geometry and commutative algebra. The motivation for this collection comes from the wide-ranging research of the distinguished mathematician, Antonio Campillo, in these and related fields. Besides his influence in the mathematical community stemming from his research, Campillo has also endeavored to promote mathematics and mathematicians' networking everywhere, especially in Spain, Latin America and Europe. Because of his impressive achievements throughout his career, we dedicate this book to Campillo in honor of his 65th birthday. Researchers and students from the world-wide, and in particular Latin American and European, communities in singularities, algebraic geometry, commutative algebra, coding theory, and other fields covered in the volume, will have interest in this book.

This book provides a detailed study of recent results in metric fixed point theory and presents several applications in nonlinear analysis, including matrix equations, integral equations and polynomial approximations. Each chapter is accompanied by basic definitions, mathematical preliminaries and proof of the main results. Divided into ten chapters, it discusses topics such as the Banach contraction principle and its converse; Ran-Reurings fixed point theorem with applications; the existence of fixed points for the class of - contractive mappings with applications to quadratic integral equations; recent results on fixed point theory for cyclic mappings with applications to the study of functional equations; the generalization of the Banach fixed point theorem on Branciari metric spaces; the existence of fixed points for a certain class of mappings satisfying an implicit contraction; fixed point results for a class of mappings satisfying a certain contraction involving extended simulation functions; the solvability of a coupled fixed point problem under a finite number of equality constraints; the concept of generalized metric spaces, for which the authors extend some well-known fixed point results; and a new fixed point theorem that helps in establishing a Kelisky-Rivlin type result for q-Bernstein polynomials and modified q-Bernstein polynomials. The book is a valuable resource for a wide audience, including graduate students and researchers.

The asymptotic distribution of eigenvalues of self-adjoint differential operators in the high-energy limit, or the semi-classical limit, is a classical subject going back to H. Weyl of more than a century ago. In the last decades there has been a renewed interest in non-self-adjoint differential operators which have many subtle properties such as instability under small perturbations. Quite remarkably, when adding small random perturbations to such operators, the eigenvalues tend to distribute according to Weyl's law (quite differently from the distribution for the unperturbed operators in analytic cases). A first result in this direction was obtained by M. Hager in her thesis of 2005. Since then, further general results have been obtained, which are the main subject of the present book. Additional themes from the theory of non-self-adjoint operators are also treated. The methods are very much based on microlocal analysis and especially on pseudodifferential operators. The reader will find a broad field with plenty of open problems.

Networks constitute the backbone of complex systems, from the human brain to computer communications, transport infrastructures to online social systems and metabolic reactions to financial markets. Characterising their structure improves our understanding of the physical, biological, economic and social phenomena that shape our world. Rigorous and thorough, this textbook presents a detailed overview of the new theory and methods of network science. Covering algorithms for graph exploration, node ranking and network generation, among others, the book allows students to experiment with network models and real-world data sets, providing them with a deep understanding of the basics of network theory and its practical applications. Systems of growing complexity are examined in detail, challenging students to increase their level of skill. An engaging presentation of the important principles of network science makes this the perfect reference for researchers and undergraduate and graduate students in physics, mathematics, engineering, biology, neuroscience and the social sciences.

This book exploits the classification of a class of linear bounded operators with rank-one self-commutators in terms of their spectral parameter, known as the principal function. The resulting dictionary between two dimensional planar shapes with a degree of shade and Hilbert space operators turns out to be illuminating and beneficial for both sides. An exponential transform, essentially a Riesz potential at critical exponent, is at the heart of this novel framework; its best rational approximants unveil a new class of complex orthogonal polynomials whose asymptotic distribution of zeros is thoroughly studied in the text. Connections with areas of potential theory, approximation theory in the complex domain and fluid mechanics are established. The text is addressed, with specific aims, at experts and beginners in a wide range of areas of current interest: potential theory, numerical linear algebra, operator theory, inverse problems, image and signal processing, approximation theory, mathematical physics.

The book serves as an introduction to holomorphic curves in symplectic manifolds, focusing on the case of four-dimensional symplectizations and symplectic cobordisms, and their applications to celestial mechanics. The authors study the restricted three-body problem using recent techniques coming from the theory of pseudo-holomorphic curves. The book starts with an introduction to relevant topics in symplectic topology and Hamiltonian dynamics before introducing some well-known systems from celestial mechanics, such as the Kepler problem and the restricted three-body problem. After an overview of different regularizations of these systems, the book continues with a discussion of periodic orbits and global surfaces of section for these and more general systems. The second half of the book is primarily dedicated to developing the theory of holomorphic curves - specifically the theory of fast finite energy planes - to elucidate the proofs of the existence results for global surfaces of section stated earlier. The book closes with a chapter summarizing the results of some numerical experiments related to finding periodic orbits and global surfaces of sections in the restricted three-body problem. This book is also part of the Virtual Series on Symplectic Geometry http://www.springer.com/series/16019

The aim of this book is to describe Calabi's original work on Kahler immersions of Kahler manifolds into complex space forms, to provide a detailed account of what is known today on the subject and to point out some open problems. Calabi's pioneering work, making use of the powerful tool of the diastasis function, allowed him to obtain necessary and sufficient conditions for a neighbourhood of a point to be locally Kahler immersed into a finite or infinite-dimensional complex space form. This led to a classification of (finite-dimensional) complex space forms admitting a Kahler immersion into another, and to decades of further research on the subject. Each chapter begins with a brief summary of the topics to be discussed and ends with a list of exercises designed to test the reader's understanding. Apart from the section on Kahler immersions of homogeneous bounded domains into the infinite complex projective space, which could be skipped without compromising the understanding of the rest of the book, the prerequisites to read this book are a basic knowledge of complex and Kahler geometry.