Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this ancient disease, Rabies has become a re-emergent infection in the developing world. The 3e updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, vaccines, public health, immunology, and epidemiology of Rabies. Chapters new to this edition cover biothreat/bioterrorism, successful wildlife control and therapies of human Rabies, and the emergence of new lyssavirus species Rabies provides physicians, public health advisors, epidemiologists, research scientists and veterinarians with single source, authoritative and up-to-date information on the diagnosis, treatment, control and prevention of this fatal infectious virus that continues to kill over 70,000 people a year.

Rabies remains a significant global public health risk with over 70,000 deaths a year. Alan Jackson a well-known researcher in this subject and has gathered a team of experts to detail the science, treatment, and control of Rabies.Completely revised, the 3e presents Rabies as a re-emergent infection with greater emphasis on a global perspective of the virus.Provides essential information to anyone diagnosing, treating, controlling and preventing the disease.70 full-color figures highlight important information in microscopic studies.

Perhaps the best-documented epidemic in the history of medicine, kuru has been studied for more than fifty years by international investigators from medicine and the human sciences. This significantly revised edition of the landmark anthropological classic Kuru Sorcery brings up to date the anthropological contribution to understanding disease, the medical research that resulted in two medical Nobel Prizes, and the views of the Fore people who endured the epidemic and who still believe that sorcerers, rather than cannibalism, caused kuru. The kuru epidemic serves as a prism through which to see how Fore notions of disease causation bring into single focus their views about the body, the world of social and spiritual relations, and changes in economic and political conditions-aspects of thought and behaviour that Western medicine keeps separate.

When we think of plagues, we think of AIDS, Ebola, anthrax spores, and, of course, the Black Death. But in 1918 the Great Flu Epidemic killed an estimated 40 million people virtually overnight. If such a plague returned today, taking a comparable percentage of the U.S. population with it, 1.5 million Americans would die.

In Flu, Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. From Alaska to Norway, from the streets of Hong Kong to the corridors of the White House, Kolata tracks the race to recover the live pathogen and probes the fear that has impelled government policy.

A gripping work of science writing, Flu addresses the prospects for a great epidemic's recurrence and considers what can be done to prevent it.

This book traces the history of the Chinese concept of "Warm diseases" (wenbing) from antiquity to the SARS epidemic. Following wenbing from its birth to maturity and even life in modern times Marta Hanson approaches the history of Chinese medicine from a new angle. She explores the possibility of replacing older narratives that stress progress and linear development with accounts that pay attention to geographic, intellectual, and cultural diversity. By doing so her book integrates the history of Chinese medicine into broader historical studies in a way that has not so far been attempted, and addresses the concerns of a readership much wider than that of Chinese medicine specialists. The persistence of wenbing and other Chinese disease concepts in the present can be interpreted as resistance to the narrowing of meaning in modern biomedical nosology. Attention to conceptions of disease and space reveal a previously unexamined discourse the author calls the Chinese geographic imagination. Tracing the changing meanings of "Warm diseases" over two thousand years allows for the exploration of pre-modern understandings of the nature of epidemics, their intersection with this geographic imagination, and how conceptions of geography shaped the sociology of medical practice and knowledge in late imperial China. Speaking of Epidemics in Chinese Medicine opens a new window on interpretive themes in Chinese cultural history as well as on contemporary studies of the history of science and medicine beyond East Asia.

The UK housing system has been described as being in 'crisis', but suddenly in 2020 homes were on the COVID-19 frontline, used for shielding, isolating and care. Most were used by more people, for more hours, for more activities. Many households were cut off from normal services and contacts, and many lost the means to pay for their homes. Millions of infections occurred at home, and inequalities in household type, housing space, cost and tenure contributed to the unequal impact of the pandemic. This book brings together a wealth of data, individual testimony and analysis, in one convenient resource for students, scholars and practitioners.

Within days of the first reports of patients suffering from a mysterious pneumonia in Wuhan, scientists in China had produced a complete genetic sequence of the virus and confirmed that it was a novel SARS-like coronavirus. The genetic sequence was deposited in a public database, making the genetic code available to scientists anywhere in the world. The result was that weeks before the WHO declared the outbreak a global public health emergency and months before COVID-19 was formally designated a pandemic, virologists around the world were already studying the protein spikes on the virus and designing vaccines, which were developed much more quickly, and turned out to be much more effective, than even the most optimistic had predicted. All of this was possible because a biological revolution had taken place a decade earlier: the world had moved into the postgenomic era. In this book, the distinguished microbiologist Hugh Pennington argues that COVID-19 is the first 'postgenomic pandemic' - that is, the first pandemic to sweep the world after the postgenomic era was initiated in 2008. Pennington explains the science behind this crucial development and shows how it has revolutionized our ways of understanding and dealing with pandemics, including the pandemic that brought our world to its knees.

The increasing emergence, re-emergence, and spread of deadly infectious diseases which pose health, economic, security and ethical challenges for states and people around the world, has given rise to an important global debate. The actual or potential burden of infectious diseases is sometimes so great that governments treat them as threats to national security. However, such treatment potentially increases the risk that emergency disease-control measures will be ineffective, counterproductive and/or unjust. Research on ethical issues associated with infectious disease is a relatively new and rapidly growing area of academic inquiry, as is research on infectious diseases within the field of security studies. This volume incorporates ethical and security perspectives, thus furthering research in both fields. Its unique focus on the intersection of ethical and security dimensions will, furthermore, generate fresh insights on how governments should respond to infectious disease challenges. Readers should include professionals and scholars working in infectious disease, epidemiology, public health, health law, health economics, public policy, bioethics, medical humanities, health and human rights, social/political philosophy, security studies, and international politics.

Plague. The word itself is like a blow, connoting misery, miasma and death. Plague takes many forms: influenza, typhus, cholera, the Black Death, and, recently, AIDS. AIDS has reminded us that epidemic infectious disease is not simply a historical phenomenon--or one limited like famine to remote continents --and is a vivid and painful illustration of how epidemics take place at a number of levels --biological event, social perception, collective response, and, finally, the individual, the existential and the moral.

"In Time of Plague"examines the many ways in which catastrophic infectious and contagious diseases are both biologically and socially defined. In the politically charged age of AIDS, "In Time of Plague" analyzes what past epidemics tell us about this new, deadly virus: How has the definition of disease differed throughout history? How have new technologies and advances in epidemiology changed our perception and response to disease? When has quarantine been appropriate or effective? What norms should govern our thinking about responsibility, culpability, legality, and confidentiality? What does society owe the victims? What, in turn, are the responsibilities of the carrier population?

Featuring essays by such distinguished scholars as Lewis Thomas, Joshua Lederberg, Dorothy Nelkin, Sander Gilman, Barbara Guttmann Rosenkrantz, Baruch S. Blumberg, George Kateb, and David A. J. Richards, among others, from a wide range of disciplines, this work seeks to answer some of these pressing questions.

Written with medical statisticians and medical researchers in mind, this intermediate-level reference explores the use of SAS for analyzing medical data. Applied Medical Statistics Using SAS covers the whole range of modern statistical methods used in the analysis of medical data, including regression, analysis of variance and covariance, longitudinal and survival data analysis, missing data, generalized additive models (GAMs), and Bayesian methods. The book focuses on performing these analyses using SAS, the software package of choice for those analysing medical data.

Features

• Covers the planning stage of medical studies in detail; several chapters contain details of sample size estimation
• Illustrates methods of randomisation that might be employed for clinical trials
• Covers topics that have become of great importance in the 21st century, including Bayesian methods and multiple imputation

Its breadth and depth, coupled with the inclusion of all the SAS code, make this book ideal for practitioners as well as for a graduate class in biostatistics or public health.

Complete data sets, all the SAS code, and complete outputs can be found on an associated website: http: //support.sas.com/amsus

The new edition of this critically praised textbook continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field; particularly the application of molecular genomics and of neuroimaging. It has been revised and enhanced to capitalize on the strengths of the first and second editions while keeping it up-to-date with the field of psychiatry and epidemiology. This comprehensive publication now includes chapters on experimental epidemiology, gene-environment interactions, the use of case registries, eating disorders, suicide, childhood disorders and immigrant populations, and the epidemiology of a number of childhood disorders.

As in the first and second editions, the objective is to provide a comprehensive, easy to understand overview of research methods for the non-specialist. The book is ideal for students of psychiatric epidemiology, psychiatric residents, general psychiatrists, and other mental health professionals.

The book features a new editor, Peter Jones, from the University of Cambridge, who joins the successful US team of Ming Tsuang and Mauricio Tohen.

A Practical Guide with Step-by-Step Explanations, Numerous Worked Examples, and R CodeThe A-Z of Error-Free Research describes the design, analysis, modeling, and reporting of experiments, clinical trials, and surveys. The book shows you when to use statistics, the best ways to cope with variation, and how to design an experiment, determine optimal sample size, and collect useable data. It also helps you choose the best statistical procedures for your application and takes you step by step through model development and reporting results for publication. Transition from Student to ResearcherHelping you become a confident researcher, the book begins with an overview of when-and when not-to use statistics. It guides you through the planning and data collection phases and presents various data analysis techniques, including methods for sample size determination. The author then covers techniques for developing models that provide a basis for future research. He also discusses reporting techniques to ensure your research efforts get the proper credit. The book concludes with case-control and cohort studies.

Global Public Health Vigilance is the first sociological book to investigate recent changes in how global public health authorities imagine and respond to international threats to human health. This book explores a remarkable period of conceptual innovation during which infectious disease, historically the focus of international disease control, was displaced by "international public health emergencies," a concept that brought new responsibilities to public health authorities, helping to shape a new project of global public health security. Drawing on research conducted at the World Health Organization, this book analyzes the formation of a new social apparatus, global public health vigilance, for detecting, responding to and containing international public health emergencies. Between 1995 and 2005 a new form of global health surveillance was invented, international communicable disease control was securitized, and international health law was fundamentally revised. This timely volume raises critical questions about the institutional effects of the concept of emerging infectious diseases, the role of the news media in global health surveillance, the impact of changes in international health law on public health reasoning and practice, and the reconstitution of the World Health Organization as a power beyond national sovereignty and global governance. It initiates a new research agenda for social science research on public health.

The Changing Era of Diseases not only explores how to end humanity's suffering from illness, but also attempts to explain the challenging problems that may arise from the control of future disease. It provides a novel perspective on how to understand the changing patterns of disease, disease development, and defense from an evolutionary point-of-view in an effort to ally the life sciences and historical approaches. Topics cover the origin of disease, its pandemic infectious manifestation, chronic and late chronic diseases, strategies of the human body to fight diseases, methods of ending diseases, and future medical systems are featured. The book is a valuable source for researchers interested in systematic approaches to disease and students who are interested in understanding the evolution of diseases and how we have succeeded in fighting them.

The science of biomedical measurements is experiencing a period of rapid development. Biomedical measuring systems are becoming increasingly accurate on the one hand and complex on the other. In order to make progress in this field, metrological problems must be solved using a systemic and formal approach. To this end, it is necessary to define the components of the system and the rules for their interaction, which allows the creation of a mathematical model. In this way, any technology or object can be presented in the form of a structure on which the necessary estimates can be formulated and synthesis, including metrological one, can be made. The authors have observed that despite the significance of the problem, few scientific centres deal with this issue in a generalised manner. Hence the idea of bringing together the achievements of the centres from Russia, Poland and Kazakhstan in one joint publication. The first and second volumes of Information Technology in Medical Diagnostics found readers not only in Poland, Ukraine, and Kazakhstan but also Spain, Russia and the Czech Republic. Following the readers' suggestions, in the third volume of ITMD we returned to the formula of closed chapters known from volume one. Due to its limited volume, the book deals with the aforementioned issues in only selected areas of biomedical engineering. The book will be of interest not only for academics and engineers but also for professionals involved in biomedical engineering, seeking solutions for the problems that cannot be solved using "traditional" technologies or trying to improve existing measurement systems.

Presents an overview of the complex biological systems used within a global public health setting and features a focus on malaria analysis Bridging the gap between agent-based modeling and simulation (ABMS) and geographic information systems (GIS), Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology provides a useful introduction to the development of agent-based models (ABMs) by following a conceptual and biological core model of Anopheles gambiae for malaria epidemiology. Using spatial ABMs, the book includes mosquito (vector) control interventions and GIS as two example applications of ABMs, as well as a brief description of epidemiology modeling. In addition, the authors discuss how to most effectively integrate spatial ABMs with a GIS. The book concludes with a combination of knowledge from entomological, epidemiological, simulation-based, and geo-spatial domains in order to identify and analyze relationships between various transmission variables of the disease. Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology also features: * Location-specific mosquito abundance maps that play an important role in malaria control activities by guiding future resource allocation for malaria control and identifying hotspots for further investigation * Discussions on the best modeling practices in an effort to achieve improved efficacy, cost-effectiveness, ecological soundness, and sustainability of vector control for malaria * An overview of the various ABMs, GIS, and spatial statistical methods used in entomological and epidemiological studies, as well as the model malaria study * A companion website with computer source code and flowcharts of the spatial ABM and a landscape generator tool that can simulate landscapes with varying spatial heterogeneity of different types of resources including aquatic habitats and houses Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology is an excellent reference for professionals such as modeling and simulation experts, GIS experts, spatial analysts, mathematicians, statisticians, epidemiologists, health policy makers, as well as researchers and scientists who use, manage, or analyze infectious disease data and/or infectious disease-related projects. The book is also ideal for graduate-level courses in modeling and simulation, bioinformatics, biostatistics, public health and policy, and epidemiology.

This comprehensive text focuses on reasoning, critical thinking and pragmatic decision making in medicine. Based on the author's extensive experience and filled with definitions, formulae, flowcharts and checklists, this fully revised second edition continues to provide invaluable guidance to the crucial role that clinical epidemiology plays in the expanding field of evidence-based medicine. Key Features: * Considers evidence-based medicine as a universal initiative common to all health sciences and professions, and all specialties within those disciplines * Demonstrates how effective practice is reliant on proper foundations, such as clinical and fundamental epidemiology, and biostatistics * Introduces the reader to basic epidemiological methods, meta-analysis and decision analysis * Shows that structured, modern, argumentative reasoning is required to build the best possible evidence and use it in practice and research * Outlines how to make the most appropriate decisions in clinical care, disease prevention and health promotion Presenting a range of topics seldom seen in a single resource, the innovative blend of informal logic and structured evidence-based reasoning makes this book invaluable for anyone seeking broad, in-depth and readable coverage of this complex and sometimes controversial field.

Looking at health and health care in a new way, this book examines health risks and benefits as encountered 'on the move' rather than focusing on the risks and benefits incurred at fixed locations. The provision and utilization of health care is also investigated, as produced/delivered and consumed/accessed in mobile settings. Engaging with the contemporary concern with 'mobilities' this book covers many forms of movement and flow, including movements of people, disease, information and health care. The issues and problems which are considered - whether re-emerging infections, displaced persons, or the 'risks' of globalised travel - are of current and ongoing concern. Drawing on three main disciplines, geography, sociology, and epidemiology, author Tony Gatrell makes strong connections between these areas of inquiry, drawing on (for example) social theorising, geographical concepts, and epidemiological methods and data. The book will be of interest to the growing number of geographers working on the geography of health, along with social scientists involved in the mobilities 'turn'. More broadly, as issues of global public health that invariably involve the movements of people, goods, viruses and information continue to hit the headlines, the book is both timely and of policy relevance.

Meta-analysis, decision analysis, and cost-effectiveness analysis are the cornerstones of evidence-based medicine. These related quantitative methods have become essential tools in the formulation of clinical and public policy based on the synthesis of evidence. All three methods are taught with increasing frequency in medical schools and schools of public health and in health policy courses at the undergraduate and graduate level. This book is a lucid introduction, and will serve the needs of students taking introductory courses that cover these topics. It will also be useful to clinicians and policymakers who need to understand the quantitative underpinnings of the methods in order to best apply the information that derives from them. The second edition of this popular book adds new material on cumulative meta-analysis as a method to explore heterogeneity. The coverage of cost-effectiveness analysis has been brought into close alignment with recommendations of the U.S. Public Health Panel on Cost-Effectiveness Analysis in Health and Medicine. Many of the examples have been replaced with more current examples, and all of the material has been updated to reflect recent advances in the methods and the emergence of consensus about some previously controversial issues. analysis. These three closely related methods have become even more important for synthesizing research since the first edition was published in 1994. And they have gained legitimacy as tools for guiding health policy. In the Second Edition, Petitti has added new material on cumlative meta-analysis and the exploration of heterogeneity, incorporated recommendations for standardizing the conduct of cost-effectiveness analysis, and updated the rest of the text.

This book highlights innovative healthcare information technologies as they perform information integration throughout various health care settings. Contributors, representative of these settings, provide case studies citing active examples of technology systems at work, addressing critical success factors, documenting success in terms of improved quality and/or reduced cost. Each example will address the full range of issues associated with technological innovation in health care, from policy and clinical considerations, to business and operational issues.

There is a huge amount of literature on statistical models for the prediction of survival after diagnosis of a wide range of diseases like cancer, cardiovascular disease, and chronic kidney disease. Current practice is to use prediction models based on the Cox proportional hazards model and to present those as static models for remaining lifetime after diagnosis or treatment. In contrast, Dynamic Prediction in Clinical Survival Analysis focuses on dynamic models for the remaining lifetime at later points in time, for instance using landmark models. Designed to be useful to applied statisticians and clinical epidemiologists, each chapter in the book has a practical focus on the issues of working with real life data. Chapters conclude with additional material either on the interpretation of the models, alternative models, or theoretical background. The book consists of four parts: * Part I deals with prognostic models for survival data using (clinical) information available at baseline, based on the Cox model * Part II is about prognostic models for survival data using (clinical) information available at baseline, when the proportional hazards assumption of the Cox model is violated * Part III is dedicated to the use of time-dependent information in dynamic prediction * Part IV explores dynamic prediction models for survival data using genomic data Dynamic Prediction in Clinical Survival Analysis summarizes cutting-edge research on the dynamic use of predictive models with traditional and new approaches. Aimed at applied statisticians who actively analyze clinical data in collaboration with clinicians, the analyses of the different data sets throughout the book demonstrate how predictive models can be obtained from proper data sets.

This book traces the history of the Chinese concept of "Warm diseases" (wenbing) from antiquity to the SARS epidemic. Following wenbing from its birth to maturity and even life in modern times Marta Hanson approaches the history of Chinese medicine from a new angle. She explores the possibility of replacing older narratives that stress progress and linear development with accounts that pay attention to geographic, intellectual, and cultural diversity. By doing so her book integrates the history of Chinese medicine into broader historical studies in a way that has not so far been attempted, and addresses the concerns of a readership much wider than that of Chinese medicine specialists. The persistence of wenbing and other Chinese disease concepts in the present can be interpreted as resistance to the narrowing of meaning in modern biomedical nosology. Attention to conceptions of disease and space reveal a previously unexamined discourse the author calls the Chinese geographic imagination. Tracing the changing meanings of "Warm diseases" over two thousand years allows for the exploration of pre-modern understandings of the nature of epidemics, their intersection with this geographic imagination, and how conceptions of geography shaped the sociology of medical practice and knowledge in late imperial China. Speaking of Epidemics in Chinese Medicine opens a new window on interpretive themes in Chinese cultural history as well as on contemporary studies of the history of science and medicine beyond East Asia.

Sir David Cox is among the most important statisticians of the past half-century. He has made pioneering and highly influential contributions to a uniquely wide range of topics in statistics and applied probability. His teaching has inspired generations of students, and many well-known researchers have begun as his graduate students or have worked with him at early stages of their careers. Legions of others have been stimulated and enlightened by the clear, concise, and direct exposition exemplified by his many books, papers, and lectures. This book presents a collection of chapters by major statistical researchers who attended a conference held at the University of Neuchatel in July 2004 to celebrate David Cox's 80th birthday. Each chapter is carefully crafted and collectively present current developments across a wide range of research areas from epidemiology, environmental science, finance, computing and medicine. Edited by Anthony Davison, Ecole Polytechnique Federale de Lausanne, Switzerland; Yadolah Dodge, University of Neuchatel, Switzerland; and N. Wermuth, Goteborg University, Sweden, with chapters by Ole E. Barndorff-Nielsen, Sarah C. Darby, Christina Davies, Peter J. Diggle, David Firth, Peter Hall, Valerie S. Isham, Kung-Yee Liang, Peter McCullagh, Paul McGale, Amilcare Porporato, Nancy Reid, Brian D. Ripley, Ignacio Rodriguez-Iturbe, Andrea Rotnitzky, Neil Shephard, Scott L. Zeger, and including a brief biography of David Cox, this book is suitable for students of statistics, epidemiology, environmental science, finance, computing and medicine, and academic and practising statisticians.

This book provides accessible treatment to state-of-the-art approaches to analyzing longitudinal studies. Comprehensive coverage of the most popular analysis tools allows readers to pick and choose the techniques that best fit their research. The analyses are illustrated with examples from major longitudinal data sets including practical information about their content and design. Illustrations from popular software packages offer tips on how to interpret the results. Each chapter features suggested readings for additional study and a list of articles that further illustrate how to implement the analysis and report the results. Syntax examples for several software packages for each of the chapter examples are provided at www.psypress.com/longitudinal-data-analysis .

Although many of the examples address health or social science questions related to aging, readers from other disciplines will find the analyses relevant to their work. In addition to demonstrating statistical analysis of longitudinal data, the book shows how to interpret and analyze the results within the context of the research design. The methods covered in this book are applicable to a range of applied problems including short- to long-term longitudinal studies using a range of sample sizes.

The book provides non-technical, practical introductions to the concepts and issues relevant to longitudinal analysis. Topics include use of publicly available data sets, weighting and adjusting for complex sampling designs with longitudinal studies, missing data and attrition, measurement issues related to longitudinal research, the use of ANOVA and regression for average change over time, mediation analysis, growth curve models, basic and advanced structural equation models, and survival analysis.

An ideal supplement for graduate level courses on data analysis and/or longitudinal modeling taught in psychology, gerontology, public health, human development, family studies, medicine, sociology, social work, and other behavioral, social, and health sciences, this multidisciplinary book will also appeal to researchers in these fields.

This book aims to fill a gap in the current construction health and safety research and discover new knowledge about work stress induced chronic diseases among construction industry professionals. In achieving these aims, the book investigates: the nature and extent of psychosocial stressors experienced by construction professionals, stress management tactics applied and the impact on mental health the prevalence and occurrence patterns of serious chronic conditions such as insomnia, obesity, musculoskeletal disorders and vision impairment aetiological pathways from job stressors through chronic diseases to job performance. While there are many studies, policies and regulations aiming to look after the health of construction workers, little attention is paid to construction professionals. By applying advanced analytical methods to data collected in a national survey of construction professionals in Australia, the author presents new scientific evidence which can be used to help establish equitable workers' compensation treatments and outcomes for construction professionals in line with other professions. Moreover, the research and analysis are underpinned by theories and literature from public health and epidemiological disciplines in addition to literature from construction, and work health, safety and wellbeing domains. It is essential reading for any health policy makers and researchers in the fields of health and safety and construction management.