This book focuses on biomaterials of different forms used for medical implants. The authors introduce the characteristics and properties of biomaterials and then dedicate special chapters to metallic, ceramic, polymeric and composite biomaterials. Case studies on sterilization methods by biomaterials are also presented. Finally, the authors describe the degradation and effects of biomaterials in living tissue.

This book analyzes several compliant contact force models within the context of multibody dynamics, while also revisiting the main issues associated with fundamental contact mechanics. In particular, it presents various contact force models, from linear to nonlinear, from purely elastic to dissipative, and describes their parameters. Addressing the different numerical methods and algorithms for contact problems in multibody systems, the book describes the gross motion of multibody systems by using a two-dimensional formulation based on the absolute coordinates and employs different contact models to represent contact-impact events. Results for selected planar multibody mechanical systems are presented and utilized to discuss the main assumptions and procedures adopted throughout this work. The material provided here indicates that the prediction of the dynamic behavior of mechanical systems involving contact-impact strongly depends on the choice of contact force model. In short, the book provides a comprehensive resource for the multibody dynamics community and beyond on modeling contact forces and the dynamics of mechanical systems undergoing contact-impact events.

This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.

This book covers the principles of advanced 3D fabrication techniques, stem cells and biomaterials for neural engineering. Renowned contributors cover topics such as neural tissue regeneration, peripheral and central nervous system repair, brain-machine interfaces and in vitro nervous system modeling. Within these areas, focus remains on exciting and emerging technologies such as highly developed neuroprostheses and the communication channels between the brain and prostheses, enabling technologies that are beneficial for development of therapeutic interventions, advanced fabrication techniques such as 3D bioprinting, photolithography, microfluidics, and subtractive fabrication, and the engineering of implantable neural grafts.There is a strong focus on stem cells and 3D bioprinting technologies throughout the book, including working with embryonic, fetal, neonatal, and adult stem cells and a variety of sophisticated 3D bioprinting methods for neural engineering applications. There is also a strong focus on biomaterials, including various conductive biomaterials and biomimetic nanomaterials such as carbon-based nanomaterials and engineered 3D nanofibrous scaffolds for neural tissue regeneration. Finally, two chapters on in vitro nervous system models are also included, which cover this topic in the context of studying physiology and pathology of the human nervous system, and for use in drug discovery research. This is an essential book for biomedical engineers, neuroscientists, neurophysiologists, and industry professionals.

This book provides an in-depth review of state-of-the-art orthopaedic techniques and basic mechanical operations (drilling, boring, cutting, grinding/milling) involved in present day orthopaedic surgery. Casting a light on exploratory hybrid operations, as well as non-conventional techniques such as laser assisted operations, this book further extends the discussion to include physical aspects of the surgery in view of material (bone) and process parameters. Featuring detailed discussion of the computational modeling of forces (mechanical and thermal) involved in surgical procedures for the planning and optimization of the process/procedure and system development, this book lays the foundations for efforts towards the future development of improved orthopaedic surgery. With topics including the role of bone machining during surgical operations; the physical properties of the bone which influence the response to any machining operation, and robotic automation, this book will be a valuable and comprehensive literature source for years to come.

Handbook of Geriatric Oncology is a practical resource for oncologists and related clinicians who want to provide comprehensive, patient-centered care to the elderly cancer patient. Divided into nine succinct sections, it includes topics spanning an Overview of Geriatric Oncology and Aging, Geriatric Syndromes, Geriatric Assessment, Select Cancers Commonly Diagnosed in the Elderly, Communication with the Older Cancer Patient, the Nursing Home Patient with Cancer, Models of Care and Survivorship, Palliative Care, and Integrative Medicine. Complex issues such as the physiologic changes of aging and their effect on cancer, corresponding social and psychological aspects that accompany aging and a cancer diagnosis, assessment of frailty, managing comorbid conditions and diseases, effective communication among healthcare providers, the patient and caregivers, as well as the risks and benefits of cancer screening, are made simpler with helpful clinical guidance and clinical pearls. Spearheaded by world experts in geriatric oncology from Memorial Sloan Kettering Cancer Center in New York, this book is the definitive resource for oncologists and related clinicians to meet the demands of clinical management along the continuum of geriatric cancer care. Key Features: Provides best practices for evaluating geriatric syndromes such as functional dependency, falls, cognitive impairment and dementia, delirium, depression and anxiety, social isolation as well as syndromes related to nutrition, comorbid conditions, and polypharmacy. Includes practical guidance on when to treat and when not to treat cancer in older patients Discusses unique factors associated with breast cancer, prostate cancer, colorectal cancer, lung cancer, ovarian cancer, bladder cancer, pancreatic cancer, head and neck cancers, and myelodysplastic syndromes in the elderly that impact care plans and treatment.

This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Advances in Family Practice Nursing is a yearly publication aimed at family practice nurse practitioners and brings you the best current clinical information from the expert editors and authors in pediatrics, geriatrics, women's health, and primary care in general. The Editor and Associate Editors identify current advances and updates in nursing care and invite authors to contribute original articles on these topics. These insightful overviews bring concepts to a clinical level and explore their everyday impact on patient care and outcomes. Whether you're looking to update your knowledge of a particular area or to read about the newest clinical advances to incorporate into your clinical care, this publication aims to appeal to all nurse practitioners providing primary care to patients.

This issue of Physician Assistant Clinics, Guest Edited by Jane McDaniel of Yale University, is devoted to Laboratory Medicine. Articles in this issue include: Rheumatology; Sexually Transmitted Infections; Provider Performed Microscopy Procedures; New Methods in Dementia Testing; Cardiology Testing; Thyroid Testing; Renal Function Testing; Anti-Xa for Heparin Monitoring and other Coagulation Studies; ABG Interpretation; Transfusion Medicine; Diagnostics for WBC Abnormalities: Leukocytosis/Leukopenia; Anemia Diagnostics for Iron Deficiency, B12/Folate Deficiency, Thalassemias, and Anemia of Chronic Disease; Hematology Testing for Hemolytic Anemias; and Liver Function Testing.

This book provides a complete overview of significant design challenges in respect to circuit miniaturization and power reduction of the neural recording system, along with circuit topologies, architecture trends, and (post-silicon) circuit optimization algorithms. The introduced novel circuits for signal conditioning, quantization, and classification, as well as system configurations focus on optimized power-per-area performance, from the spatial resolution (i.e. number of channels), feasible wireless data bandwidth and information quality to the delivered power of implantable system.

This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.

This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson's, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples.

Atlas of Wound Healing: A Tissue Regeneration Approach presents a variety of wounds with diverse ethnicities and etiologies. The content is translational in nature, straddling the disciplines of bioengineering and clinical medicine. Part 1 showcases the latest wound healing methods and treatment plans based on tissue regeneration. Part 2 features patient case reports that illustrate different types of wounds in varying sizes, stages, and initial conditions, as well as concise treatment protocols. Describes the principles of wound and tissue healing Offers comprehensive visual case reporting for varied patient backgrounds Provides to-the-point treatment protocols based on a tissue regeneration approach

This comprehensive book thoroughly covers bone health in the adolescent, offering evidence-based guidance for clinical care in the primary care setting, and includes aspects of endocrinology, nutrition, radiology, sports medicine, and rehabilitation. A Practical Approach to Adolescent Bone Health begins with an in-depth review of normal bone physiology, and explains how to optimize bone mass accrual in the healthy adolescent. The following chapters detail the importance of nutrition and physical activity to the skeletal system, while later chapters provide a bone-centric review of clinical history taking, the physical examination, laboratory assessment, and imaging to evaluate bone health. Final chapters delve into providing comprehensive care for specific conditions commonly found in the adolescent, including adolescents with multiple fractures, eating disorders, athletic involvement, chronic illness, various ambulatory limitations, and bone fragility. Clinical vignettes are woven into chapters throughout the book, providing real-world application and highlighting key concepts for practitioners. A Practical Approach to Adolescent Bone Health is a unique resource,and ideal for the primary care clinician, including pediatricians, adolescent medicine specialists, and family medicine physicians, as well as endocrinologists, orthopedic surgeons, and any other practitioner working to guide adolescents towards optimal bone health.

This book is designed to present a state-of the-art approach to the assessment and management of bereavement-related psychopathology. Written by experts in the fi eld, it addresses the recent shift in the fi eld calling for greater recognition of bereavement-related psychopathology, as evidenced by the removal of bereavement from the exclusion criteria for major depressive disorder and the provisional inclusion of a bereavement disorder as a condition requiring further study in the DSM-5. Th is text introduces and reviews the theoretical background underlying bereavement-related psychopathology, addresses the issues faced by clinicians who assess bereaved individuals in diff erent contexts, and reviews the management of and varied treatment approaches for individuals with grief reactions. Clinical Handbook of Bereavement and Grief Reactions is a valuable resource for psychiatrists, psychologists, students, counselors, psychiatric nurses, social workers, and all medical professionals working with patients struggling with bereavement and grief reactions.

Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.

"In this 2nd edition, Robinson and Reiter give us an updated blueprint for full integration of behavioral health and primary care in practice. They review the compelling rationale, but their real contribution is telling us exactly HOW to think about it and how to do it. This latest book is a must for anyone interested in population health and the nuts and bolts of full integration through using the Primary Care Behavioral Health Consultation model." Susan H McDaniel Ph.D., 2016 President, American Psychological Association Professor, University of Rochester Medical Center The best-selling guide to integrating behavioral health services into primary care is now updated, expanded and better than ever! Integration is exploding in growth, and it is moving inexorably toward the model outlined here. To keep pace, this revised text is a must for primary care clinicians and administrators. It is also essential reading for graduate classes in a variety of disciplines, including social work, psychology, and medicine. This updated edition includes: * A refined presentation of the Primary Care Behavioral Health (PCBH) model * The latest terms, trends and innovations in primary care * Comprehensive strategies and resource lists for hiring and training new Behavioral Health Consultants (BHC) * Step-by-step guidance for implementing the PCBH model * A plethora of evolved practice tools, including new Core Competency Tools for BHCs and primary care providers * Sample interventions for behaviorally influenced problems * The use of "Third Wave" behavior therapies in primary care * Detailed program evaluation instructions and tools * The latest on financing integrated care * An entire chapter on understanding and addressing the prescription drug abuse epidemic * Experienced guidance on ethical issues in the PCBH model * Improved patient education handouts With all of the changes in health care, the potential for the Primary Care Behavioral Health (PCBH) model to improve primary care-and the health of the population-is greater than ever. This book should be the first read for anyone interested in realizing the potential of integration.

This book is a must for all MRCP candidates. Together with the two companion volumes, the book provides a comprehensive guide to the written paper MRCP syllabus.

Volume 3 covers the data interpretation component of the exam. The 100 data questions contained in this book encompass the full range of general medical problems encountered in hospital practice. The final chapter of this volume is devoted to Extended Matching Questions, which are increasingly used in the MRCP Written Paper. Familiarity with the contents of this book, will ensure that all candidates stand the best chance of passing the exam first time!

Trauma-informed care is emerging as a critical component of pediatric best practices. With this new practical guide, pediatricians and other child health professionals will learn to identify, evaluate, and treat children and families affected by trauma and adversity when they present at the office. In addition to instruction for acute, hands-on care, the cohesive approach offered in this guide also lays out a framework and concrete steps to transform practices into ones that are trauma-sensitive and can provide the best, most impactful care to all patients. Childhood Trauma and Resilience: A Practical Guide includes mnemonics, charts, tables, and numerous case studies to reinforce learning, as well as timely information on physician burnout and secondary traumatic stress. More than 20 reproducible handouts on topics such as attachment, cultural connections, and promoting resilience, will help pediatricians engage with parents on these important related topics and focus on the family factors that can help prevent and mitigate the effects of trauma.

Professional practice in health care and education is currently undergoing major reform as it adapts to complex and rapidly changing environments.

This multi-authored text explores professional practice in health, education and the creative arts in the four key practice dimensions: doing, knowing, being and becoming. These areas are used to explore the reality of professional practice as something more than the application of learned knowledge in practice situations.

Professional practice is presented as a lived experience as well as a process; a service for (and with) others, and a way of being and behaving. The text uses discourse, narrative, imagery and critical debate to explore the essential unity of knowledge and practice. The emphasis here is on understanding creative arts expertise, professional artistry and creativity in practice."

Professional Practice in Health, Education and the Creative Art" is for all those seeking to learn, improve and transform professional practice. It:
Encourages reflective, visionary, innovative and creative practice
Actively promotes the blurring of restrictive practice boundaries
Offers an interesting new perspective for the analysis of professional practice
Provides practical strategies for professional development
Includes internationally recognized authors from the fields of education, health sciences and the creative arts
Reflects the cutting edge of thinking on professional practice

This book is an essential purchase for practitioners, educators and researchers in nursing, allied health professions, medicine and the creative arts who are engaged or interested in practice, and for the otherprofessional people and members of the community interested in the way professionals practice and frame their practice.

This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.

In this thorough revision, updating, and expansion of his great 2007 book, Empathy in Patient Care, Professor Hojat offers all of us in healthcare education an uplifting magnum opus that is sure to greatly enhance how we conceptualize, measure, and teach the central professional virtue of empathy. Hojat's new Empathy in Health Professions Education and Patient Care provides students and professionals across healthcare with the most scientifically rigorous, conceptually vivid, and comprehensive statement ever produced proving once and for all what we all know intuitively - empathy is healing both for those who receive it and for those who give it. This book is filled with great science, great philosophizing, and great 'how to' approaches to education. Every student and practitioner in healthcare today should read this and keep it by the bedside in a permanent place of honor. Stephen G Post, Ph.D., Professor of Preventive Medicine, and Founding Director of the Center for Medical Humanities, Compassionate Care, and Bioethics, School of Medicine, Stony Brook University Dr. Hojat has provided, in this new edition, a definitive resource for the evolving area of empathy research and education. For those engaged in medical student or resident education and especially for those dedicated to efforts to improve the patient experience, this book is a treasure trove of primary work in the field of empathy. Leonard H. Calabrese, D.O., Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University The latest edition of Empathy in Health Professions Education and Patient Care grounds the clinical art of empathic caring in the newly recognized contributions of brain imagery and social cognitive neuroscience. Furthermore, it updates the accumulating empirical evidence for the clinical effects of empathy that has been facilitated by the widespread use of the Jefferson Scale of Empathy, a generative contribution to clinical research by this book's author. In addition, the book is so coherently structured that each chapter contributes to an overall understanding of empathy, while also covering its subject so well that it could stand alone. This makes Empathy in Health Professions Education and Patient Care an excellent choice for clinicians, students, educators and researchers. Herbert Adler, M.D., Ph.D. Clinical Professor of Psychiatry and Human Behavior,Sidney Kimmel Medical College at Thomas Jefferson University It is my firm belief that empathy as defined and assessed by Dr. Hojat in his seminal book has far reaching implications for other areas of human interaction including business, management, government, economics, and international relations. Amir H. Mehryar, Ph.D., Emeritus Professor of Behavioral Sciences and Population Studies, Institute for Research and Training in Management and Planning, Tehran, Iran

This book highlights recent advances in soft and stretchable biointegrated electronics. A renowned group of authors address key ideas in the materials, processes, mechanics, and devices of soft and stretchable electronics; the wearable electronics systems; and bioinspired and implantable biomedical electronics. Among the topics discussed are liquid metals, stretchable and flexible energy sources, skin-like devices, in vitro neural recording, and more. Special focus is given to recent advances in extremely soft and stretchable bio-inspired electronics with real-world clinical studies that validate the technology. Foundational theoretical and experimental aspects are also covered in relation to the design and application of these biointegrated electronics systems. This is an ideal book for researchers, engineers, and industry professionals involved in developing healthcare devices, medical tools and related instruments relevant to various clinical practices.