This book gathers the proceedings of the IV International Conference on Biomedical and Health Informatics (ICBHI 2019), held on 17-20 April, 2019, in Taipei, Taiwan. Contributions span a range of topics, including medical imaging, biosignal processing, biodata management and analytics, public and personalized health systems, mobile health applications and many more. The IV conference edition gave a special emphasis to cybersecurity issues and cutting-edge medical devices, as it is reflected in this book, which provides academics and professionals with extensive knowledge on and a timely snapshot of cutting-edge research and developments in the field of biomedical and health informatics.

This book constitutes the refereed proceedings of the 4th International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2019, held in conjunction with MICCAI 2019, in Shenzhen, China, in October 2019.The 16 full papers presented were carefully reviewed and selected from 21 submissions. The contributions span the following broad categories in alignment with the initial call-for-papers: methods based on generative models or adversarial learning for MRI/CT/PET/microscopy image synthesis, image super resolution, and several applications of image synthesis and simulation for data augmentation, segmentation or lesion detection.

This book constitutes the refereed proceedings of the First International Workshop on Connectomics in Artificial Intelligence in Radiation Therapy, AIRT 2019, held in conjunction with MICCAI 2019 in Shenzhen, China, in October 2019. The 20 full papers presented were carefully reviewed and selected from 24 submissions. The papers discuss the state of radiation therapy, the state of AI and related technologies, and hope to find a pathway to revolutionizing the field to ultimately improve cancer patient outcome and quality of life.

The six-volume set LNCS 11764, 11765, 11766, 11767, 11768, and 11769 constitutes the refereed proceedings of the 22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019, held in Shenzhen, China, in October 2019. The 539 revised full papers presented were carefully reviewed and selected from 1730 submissions in a double-blind review process. The papers are organized in the following topical sections: Part I: optical imaging; endoscopy; microscopy. Part II: image segmentation; image registration; cardiovascular imaging; growth, development, atrophy and progression. Part III: neuroimage reconstruction and synthesis; neuroimage segmentation; diffusion weighted magnetic resonance imaging; functional neuroimaging (fMRI); miscellaneous neuroimaging. Part IV: shape; prediction; detection and localization; machine learning; computer-aided diagnosis; image reconstruction and synthesis. Part V: computer assisted interventions; MIC meets CAI. Part VI: computed tomography; X-ray imaging.

This book constitutes the proceedings of the Third International Conference on Physiological Computing Systems, PhyCS 2016, held in Lisbon, Portugal, in July 2016. The 12 papers presented in this volume were carefully reviewed and selected from numerous submissions. They contribute to the understanding of relevant trends of current research on physiological computing systems, including brain-computer interfaces, virtual reality, psychophysiological load assessment in unconstrained scenarios, body tracking and movement pattern recognition, emotion recognition, machine learning applied to diabetes and hypertension, tangible biofeedback technologies, multimodal sensor data fusion, and deep learning for hand gesture recognition.

This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, held in Funchal, Madeira, Portugal, in January 2018.The 25 revised full papers presented were carefully reviewed and selected from a total of 299 submissions. The papers are organized in topical sections on biomedical electronics and devices; bioimaging; bioinformatics models, methods and algorithms; health informatics.

This two-volume set LNCS 11662 and 11663 constitutes the refereed proceedings of the 16th International Conference on Image Analysis and Recognition, ICIAR 2019, held in Waterloo, ON, Canada, in August 2019. The 58 full papers presented together with 24 short and 2 poster papers were carefully reviewed and selected from 142 submissions. The papers are organized in the following topical sections: Image Processing; Image Analysis; Signal Processing Techniques for Ultrasound Tissue Characterization and Imaging in Complex Biological Media; Advances in Deep Learning; Deep Learning on the Edge; Recognition; Applications; Medical Imaging and Analysis Using Deep Learning and Machine Intelligence; Image Analysis and Recognition for Automotive Industry; Adaptive Methods for Ultrasound Beamforming and Motion Estimation.

This book constitutes the refereed proceedings of the 12th SIGSAND/PLAIS EuroSymposium 2019 held in Gdansk, Poland, on September 19, 2019. The objective of the EuroSymposium on Systems Analysis and Design is to promote and develop high quality research on all issues related to information systems (IS) and in particular in systems analysis and design (SAND). The 12 papers presented in this volume were carefully reviewed and selected from 32 submissions. They were organized in topical sections named: information systems in business; health informatics and life-long-learning; IT security; agile methods and software engineering.

This book constitutes the refereed proceedings of the 9th International Conference on Pervasive Computing Paradigms for Mental Health, MindCare 2019, held in Buenos Aires, Argentina, in April 2019. The 22 papers presented were carefully reviewed and selected from 38 submissions and present new paradigms in mental healthcare, in parallel with compelling questions about how it is possible to promote and structure these changes to improve physical well-being.

This volume presents the proceedings of the Brazilian Congress on Biomedical Engineering (CBEB 2018). The conference was organised by the Brazilian Society on Biomedical Engineering (SBEB) and held in Armacao de Buzios, Rio de Janeiro, Brazil from 21-25 October, 2018. Topics of the proceedings include these 11 tracks: * Bioengineering * Biomaterials, Tissue Engineering and Artificial Organs * Biomechanics and Rehabilitation * Biomedical Devices and Instrumentation * Biomedical Robotics, Assistive Technologies and Health Informatics * Clinical Engineering and Health Technology Assessment * Metrology, Standardization, Testing and Quality in Health * Biomedical Signal and Image Processing * Neural Engineering * Special Topics * Systems and Technologies for Therapy and Diagnosis

This volume presents the proceedings of the 7th International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 27-29, 2018 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. It aims to identify new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

This book presents the key technology of electronic noses, and systematically describes how e-noses can be used to automatically analyse odours. Appealing to readers from the fields of artificial intelligence, computer science, electrical engineering, electronics, and instrumentation science, it addresses three main areas: First, readers will learn how to apply machine learning, pattern recognition and signal processing algorithms to real perception tasks. Second, they will be shown how to make their algorithms match their systems once the algorithms don't work because of the limitation of hardware resources. Third, readers will learn how to make schemes and solutions when the acquired data from their systems is not stable due to the fundamental issues affecting perceptron devices (e.g. sensors). In brief, the book presents and discusses the key technologies and new algorithmic challenges in electronic noses and artificial olfaction. The goal is to promote the industrial application of electronic nose technology in environmental detection, medical diagnosis, food quality control, explosive detection, etc. and to highlight the scientific advances in artificial olfaction and artificial intelligence. The book offers a good reference guide for newcomers to the topic of electronic noses, because it refers to the basic principles and algorithms. At the same time, it clearly presents the key challenges - such as long-term drift, signal uniqueness, and disturbance - and effective and efficient solutions, making it equally valuable for researchers engaged in the science and engineering of sensors, instruments, chemometrics, etc.

This book introduces readers to the methods, types of data, and scale of analysis used in the context of health. The challenges of working with big data are explored throughout the book, while the benefits are also emphasized through the discoveries made possible by linking large datasets. Methods include thorough case studies from statistics, as well as the newest facets of data analytics: data visualization, modeling and simulation, and machine learning. The diversity of datasets is illustrated through chapters on networked data, image processing, and text, in addition to typical structured numerical datasets. While the methods, types of data, and scale have been individually covered elsewhere, by bringing them all together under one "umbrella" the book highlights synergies, while also helping scholars fluidly switch between tools as needed. New challenges and emerging frontiers are also discussed, helping scholars grasp how methods will need to change in response to the latest challenges in health.

This book offers examples of how data science, big data, analytics, and cloud technology can be used in healthcare to significantly improve a hospital's IT Energy Efficiency along with information on the best ways to improve energy efficiency for healthcare in a cost effective manner. The book builds on the work done in other sectors (mainly data centers) in effectively measuring and improving IT energy efficiency and includes case studies illustrating power and cooling requirements within Green Healthcare. Making Healthcare Green will appeal to professionals and researchers working in the areas of analytics and energy efficiency within the healthcare fields.

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

This book provides an overview of modern sensing technologies and reflects the remarkable advances that have been made in the field of intelligent and smart sensors, environmental monitoring, health monitoring, and many other sensing and monitoring contexts in today's world. It addresses a broad range of aspects, from human health monitoring to the monitoring of environmental conditions, from wireless sensor networks and the Internet of Things to structural health monitoring. Given its breadth of scope, the book will benefit researchers, practitioners, technologists and graduate students involved in the monitoring of systems within the human body, functions and activities, healthcare technologies and services, the environment, etc.

This book describes breath signal processing technologies and their applications in medical sample classification and diagnosis. First, it provides a comprehensive introduction to breath signal acquisition methods, based on different kinds of chemical sensors, together with the optimized selection and fusion acquisition scheme. It then presents preprocessing techniques, such as drift removing and feature extraction methods, and uses case studies to explore the classification methods. Lastly it discusses promising research directions and potential medical applications of computerized breath diagnosis. It is a valuable interdisciplinary resource for researchers, professionals and postgraduate students working in various fields, including breath diagnosis, signal processing, pattern recognition, and biometrics.

This textbook begins with an introduction to the US healthcare delivery system, its many systemic challenges and the prior efforts to develop and deploy informatics tools to help overcome those problems. It goes on to discuss health informatics from an historical perspective, its current state and its likely future state now that electronic health record systems are widely deployed, the HL7 Fast Healthcare Interoperability standard is being rapidly accepted as the means to access the data stored in those systems and analytics is increasing being used to gain new knowledge from that aggregated clinical data. It then turns to some of the important and evolving areas of informatics including population and public health, mHealth and big data and analytics. Use cases and case studies are used in all of these discussions to help readers connect the technologies to real world challenges. Effective use of informatics systems and tools by providers and their patients is key to improving the quality, safety and cost of healthcare. With health records now digital, no effective means has existed for sharing them with patients, among the multiple providers who may care for them and for important secondary uses such as public/population health and research. This problem is a topic of congressional discussion and is addressed by the 21st Century Cures Act of 2016 that mandates that electronic health record (EHR) systems offer a patient-facing API. HL7's Fast Healthcare Interoperability Resources (FHIR) is that API and this is the first comprehensive treatment of the technology and the many ways it is already being used. FHIR is based on web technologies and is thus a far more facile, easy to implement approach that is rapidly gaining acceptance. It is also the basis for a 'universal health app platform' that literally has the potential to foster innovation around the data in patient records similar to the app ecosystems smartphones created around the data they store. FHIR app stores have already been opened by Epic and Cerner, the two largest enterprise EHR vendors. Provider facing apps are already being explored to improve EHR usability and support personalized medicine. Medicare and the Veteran's Administration have announced FHIR app platforms for their patients. Apple's new IOS 11.3 features the ability for consumers to aggregate their health records on their iPhone using FHIR. Health insurance companies are exploring applications of FHIR to improve service and communication with their providers and patients. SureScripts, the national e-Prescribing network, is using FHIR to help doctors know if their patients are complying with prescriptions. This textbook is for introductory health informatics courses for computer science and health sciences students (e.g. doctors, nurses, PhDs), the current health informatics community, IT professionals interested in learning about the field and practicing healthcare providers. Though this textbook covers an important new technology, it is accessible to non-technical readers including healthcare providers, their patients or anyone interested in the use of healthcare data for improved care, public/population health or research.

This book constitutes the proceedings of the 9th International Conference on Exploring Services Science, IESS 2018, held in Karlsruhe, Germany, in September 2018. The 30 papers presented in this volume were carefully reviewed and selected from 67 submissions. The book is structured in six parts, each featuring contributions describing current research in a particular domain of service science: Service Design and Innovation; Smart Service Processes; Big Data in Services; Service Topics Open Exploration; Design Science Research in Services. The book offers an extended, ICT-focused vision on services and addresses multiple relevant aspects, including underlying business models, the necessary processes and technological capabilities like big data and machine learning. The academic work showcased at the conference should help to advance service science and its application in practice.

This book is open access under a CC BY-NC 2.5 license. This book presents the VISCERAL project benchmarks for analysis and retrieval of 3D medical images (CT and MRI) on a large scale, which used an innovative cloud-based evaluation approach where the image data were stored centrally on a cloud infrastructure and participants placed their programs in virtual machines on the cloud. The book presents the points of view of both the organizers of the VISCERAL benchmarks and the participants. The book is divided into five parts. Part I presents the cloud-based benchmarking and Evaluation-as-a-Service paradigm that the VISCERAL benchmarks used. Part II focuses on the datasets of medical images annotated with ground truth created in VISCERAL that continue to be available for research. It also covers the practical aspects of obtaining permission to use medical data and manually annotating 3D medical images efficiently and effectively. The VISCERAL benchmarks are described in Part III, including a presentation and analysis of metrics used in evaluation of medical image analysis and search. Lastly, Parts IV and V present reports by some of the participants in the VISCERAL benchmarks, with Part IV devoted to the anatomy benchmarks and Part V to the retrieval benchmark. This book has two main audiences: the datasets as well as the segmentation and retrieval results are of most interest to medical imaging researchers, while eScience and computational science experts benefit from the insights into using the Evaluation-as-a-Service paradigm for evaluation and benchmarking on huge amounts of data.

This is the first book offering a systematic description of tongue image analysis and processing technologies and their typical applications in computerized tongue diagnostic (CTD) systems. It features the most current research findings in all aspects of tongue image acquisition, preprocessing, classification, and diagnostic support methodologies, from theoretical and algorithmic problems to prototype design and development of CTD systems. The book begins with a very in-depth description of CTD on a need-to-know basis which includes an overview of CTD systems and traditional Chinese medicine (TCM) in order to provide the information on the context and background of tongue image analysis. The core part then introduces algorithms as well as their implementation methods, at a know-how level, including image segmentation methods, chromatic correction, and classification of tongue images. Some clinical applications based on these methods are presented for the show-how purpose in the CTD research field. Case studies highlight different techniques that have been adopted to assist the visual inspection of appendicitis, diabetes, and other common diseases. Experimental results under different challenging clinical circumstances have demonstrated the superior performance of these techniques. In this book, the principles of tongue image analysis are illustrated with plentiful graphs, tables, and practical experiments to provide insights into some of the problems. In this way, readers can easily find a quick and systematic way through the complicated theories and they can later even extend their studies to special topics of interest. This book will be of benefit to researchers, professionals, and graduate students working in the field of computer vision, pattern recognition, clinical practice, and TCM, as well as those involved in interdisciplinary research.

This book describes how the creation of new digital services-through vertical and horizontal integration of data coming from sensors on top of existing legacy systems-that has already had a major impact on industry is now extending to healthcare. The book describes the fourth industrial revolution (i.e. Health 4.0), which is based on virtualization and service aggregation. It shows how sensors, embedded systems, and cyber-physical systems are fundamentally changing the way industrial processes work, their business models, and how we consume, while also affecting the health and care domains. Chapters describe the technology behind the shift of point of care to point of need and away from hospitals and institutions; how care will be delivered virtually outside hospitals; that services will be tailored to individuals rather than being designed as statistical averages; that data analytics will be used to help patients to manage their chronic conditions with help of smart devices; and that pharmaceuticals will be interactive to help prevent adverse reactions. The topics presented will have an impact on a variety of healthcare stakeholders in a continuously global and hyper-connected world. * Presents explanations of emerging topics as they relate to e-health, such as Industry 4.0, Precision Medicine, Mobile Health, 5G, Big Data, and Cyber-physical systems; * Provides overviews of technologies in addition to possible application scenarios and market conditions; * Features comprehensive demographic and statistic coverage of Health 4.0 presented in a graphical manner.

This book presents advances in biomedical imaging analysis and processing techniques using time dependent medical image datasets for computer aided diagnosis. The analysis of time-series images is one of the most widely appearing problems in science, engineering, and business. In recent years this problem has gained importance due to the increasing availability of more sensitive sensors in science and engineering and due to the wide-spread use of computers in corporations which have increased the amount of time-series data collected by many magnitudes. An important feature of this book is the exploration of different approaches to handle and identify time dependent biomedical images. Biomedical imaging analysis and processing techniques deal with the interaction between all forms of radiation and biological molecules, cells or tissues, to visualize small particles and opaque objects, and to achieve the recognition of biomedical patterns. These are topics of great importance to biomedical science, biology, and medicine. Biomedical imaging analysis techniques can be applied in many different areas to solve existing problems. The various requirements arising from the process of resolving practical problems motivate and expedite the development of biomedical imaging analysis. This is a major reason for the fast growth of the discipline.

This book provides a thorough overview of the Wisdom Web of Things (W2T), a holistic framework for computing and intelligence in an emerging hyper-world with a social-cyber-physical space. Fast-evolving Web intelligence research and development initiatives are now moving toward understanding the multifaceted nature of intelligence and incorporating it at the Web scale in a ubiquitous environment with data, connection and service explosion. The book focuses on the framework and methodology of W2T, as well as its applications in different problem domains, such as intelligent businesses, urban computing, social computing, brain informatics and healthcare. From the researcher and developer perspectives, the book takes a systematic, structured view of various W2T facets and their overall contribution to the development of W2T as a whole. Written by leading international researchers, this book is an essential reference for researchers, educators, professionals, and tertiary HDR students working on the World Wide Web, ubiquitous computing, knowledge management, and business intelligence.

This book presents advanced methodologies in two areas related to electroencephalogram (EEG) signals: detection of epileptic seizures and identification of mental states in brain computer interface (BCI) systems. The proposed methods enable the extraction of this vital information from EEG signals in order to accurately detect abnormalities revealed by the EEG. New methods will relieve the time-consuming and error-prone practices that are currently in use. Common signal processing methodologies include wavelet transformation and Fourier transformation, but these methods are not capable of managing the size of EEG data. Addressing the issue, this book examines new EEG signal analysis approaches with a combination of statistical techniques (e.g. random sampling, optimum allocation) and machine learning methods. The developed methods provide better results than the existing methods. The book also offers applications of the developed methodologies that have been tested on several real-time benchmark databases. This book concludes with thoughts on the future of the field and anticipated research challenges. It gives new direction to the field of analysis and classification of EEG signals through these more efficient methodologies. Researchers and experts will benefit from its suggested improvements to the current computer-aided based diagnostic systems for the precise analysis and management of EEG signals.