Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions -discusses the genetic determinants of mucociliary system structure and function -explains ciliary wave activity in cell-cell communication -elucidates many of the key physiological processes in ciliary regulation -reveals possible means of treating irregularities in mucus secretion and clearance -improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia -approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques -and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

This book is a collection of works that canvass many of the recent developments in various areas of connective tissue research. It focuses on the structure of the components, molecular organization and pathology of the extracellular matrix.

Liquid Biopsy: New Challenges in the era of Immunotherapy and Precision Oncology aims to describe links between cancer, precision oncology, and liquid biopsy, focusing on their participation to immunotherapy management. The book provides updated information on the main applications of liquid biopsy and immunotherapy as well as interesting aspects useful for planning basic and translational research activities. It helps readers understand the central aspects of precision medicine in oncology, including the use of new generation technologies for translational and diagnostic settings and the main clinical trials in this area that may be useful during their research. The book is a valuable source for cancer researchers, oncologists and other members of the medical and biomedical field who are interested in learning more about recent developments in liquid biopsy and its relationship with precision medicine and immunotherapy.

Widely used by residents, fellows, and practicing pathologists around the world, Gattuso's Differential Diagnosis in Surgical Pathology provides a user-friendly road map to the main criteria to consider in order to differentiate between a variety of potential diagnoses that all have a very similar appearance. This comprehensive guide helps you make informed decisions for even your most complex and challenging cases, presenting a comprehensive differential diagnosis list and comparisons for every entity discussed. The 4th Edition brings you fully up to date with updated diagnostic techniques, new classifications, and new content throughout-perfect for quick reference at every microscope in the sign-out room. Provides brief descriptions of both common and uncommon disorders, with an emphasis on differential diagnosis, along with excellent illustrative examples of the pathology and carefully selected references. Streamlines the differential diagnosis process by offering a series of bullet point checklists that detail the respective features of the entities being considered. Discusses a complete range of tumors and tumor-like conditions in all organ systems. Contains updated information on personalized/precision medicine especially as it pertains to the immunotherapies; for example, PDL-1 targeted therapies in many cancers. Includes new classification of neuroendocrine tumors, new classification and updates of follicular variant of papillary thyroid carcinoma, and a new section on the most common metastatic tumors and utilization of ancillary techniques for diagnosis and molecular studies. Uses a reader friendly, outline format for each diagnosis that details clinical information, epidemiology, gross and microscopic findings, ancillary stains and tests, differential diagnoses, and pearls of wisdom. Features 1,400 full-color macro- and micrographs that provide a realistic basis for comparison of what you see under the microscope. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

A new volume in the highly regarded Biopsy Interpretation Series, Biopsy Interpretation of the Lymph Node provides concise, abundantly illustrated information on the pathologic approach to diagnosis for these frequently encountered biopsies. Practical and well organized, this highly readable volume edited by Drs. Rebecca L. King, Anamarija M. Perry, and Lauren B. Smith, addresses both common and unusual issues that arise in the day-to-day interpretation of non-neoplastic and neoplastic lymph node biopsies, teaching the best diagnostic practices as well as how to avoid the most common pitfalls. Focusing on the daily tasks and needs of the general pathologist, it provides a solid foundation for clinical diagnostic decision making. Frames each diagnosis in its most common clinical context, explaining how the pathology can be used to make key clinical management decisions Features high-quality photomicrographs and illustrations throughout—more than 400 images in all Covers the pattern-based approach to lymph node evaluation, giving special emphasis to differential diagnosis and limitations of small biopsies Addresses diagnostic methods and ancillary studies used in lymph node pathology such as immunohistochemistry, flow cytometry, FISH, and molecular studies Provides eBook access to questions and answers for self-assessment and exam review Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

Throughout the world, cardiovascular diseases associated with ischemic and reperfusion organ injuries are among the main factors of human mortality. Hence, the analysis of mechanisms responsible for these injuries and the development of approaches to their prevention and treatment present a pressing problem for specialists in biology and medicine.

This book is based on firsthand experience gained by the author and her research team during many years of experimental studies, supported by the analysis of abundant literature published between 1970 and 1999. It deals with the comparative assessment of ischemic and reperfusion injuries and their mechanisms in vitally important organs differing in their sensitivity to oxygen deficiency, metabolic activity, and provision with radical-generating and antioxidant system. A distinctive feature of the monograph, compared to previous studies in this field, is that attention is focused on the role of free-radical reactions, their place among other damaging factors (disturbances of energy metabolism, intensification of lipolysis and phospholipolysis, etc.), a detailed analysis of mechanisms responsible for the formation of free radicals during ischemia (the roles of electron transport pathways, radical-generating enzymes, macrophages, endothelial cells, etc, ), and a general review of modern methods of antiradical and antiischemic therapy. None of the books published to date is characterized by such an approach to the problem.

With its unique algorithmic and pattern-based approach, Diagnosis of Neoplasia in Endometrial Biopsies is an essential practical guide to interpreting endometrial biopsy samples. All potential entities are classified based on the dominant histologic pattern, with each resulting sub-group progressively sub-classified to reach a diagnosis. Decision tree flowcharts facilitate rapid narrowing of the differential diagnosis. Recent advancements are discussed and explained, and strengths and limitations of diagnostic tests are identified in the context of their application to the biopsy sample. Lavishly illustrated throughout, this book serves the practising pathologist as a scope-side assistant for quick reference, up-to-date guidance, and recommendations for ancillary testing. For the resident, this book facilitates quick and comprehensive mastery of the interpretation and diagnosis of endometrial biopsies. The book is packaged with a password, giving the user online access to all the text and images.

Written and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field's definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween's is a convenient, one-stop resource for use in the reporting room as well as in personal study. Shares the knowledge and experience of a "who's who" list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hubscher. Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout. Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Evolution in the field of diagnostic hematopathology has been remarkable. The World Health Organization (WHO) classification scheme for hematologic neoplasms has achieved widespread endorsement and acceptance in clinical practice. This volume integrates proposed WHO 2016 recommendations and highlights areas in which further classification revisions may occur, or areas in which criteria are controversial. In addition, the immunophenotypic and molecular genetic tests of greatest value in diagnoses, risk assessment, and disease monitoring are highlighted in the text. The substantial focus on molecular genetic findings for each neoplasm parallels the ever-expanding role of genetics in disease classification and risk assessment. Key problem areas and differential diagnostic considerations are also included for each neoplastic disease category. Although primary blood and bone marrow neoplasms are the focus of this text, metastatic neoplasms in bone marrow are also covered. This atlas will provide readers with comprehensive information necessary for the clinical assessment of bone marrow neoplasms for years to come.

Since the publication of the third edition there have been several changes in the pathology and classification of these lesions. The current edition updates the status of heart tumours, with emphasis on newer findings, especially molecular advances. In most cases, the authors have followed the classification of the World Health Organization, whose updated volume on tumours of the lung, heart, and mediastinum is forthcoming. Because newer imaging modalities, especially cardiac magnetic resonance imaging and 3-D echocardiography are increasingly used in preoperative evaluation of heart tumours, the authors have introduced a chapter devoted exclusively to radiologic diagnosis. In addition, inflammatory myofibroblastic tumour, a less common tumour of heart valves, is covered quite differently from the previous volume, since several reports and series of this childhood tumour have emerged. This atlas has carried over a discussion of lesions that are neither neoplastic nor hamartomatous, such as thrombi and some infections that can mimic tumours, because some of these lesions, especially thrombi, are among the more commonly-excised heart masses, and may present diagnostic challenge. This work is a useful source for physicians who wish to find a reference to classify a tumour of the heart, or update their knowledge of these lesions.

The current edition contains new information accumulated during the last ten years on tumours and tumour-like lesions of the gallbladder, extrahepatic bile ducts and Vaterian system. Because of the increasing number of laparoscopic cholecystectomies and Whipple procedures performed, surgical pathologists now have the opportunity to examine more cancer precursors, early cancers, and adenomas of the gallbladder, extrahepatic bile ducts and ampulla of Vater than previously. These lesions are discussed in detail and profusely illustrated. Likewise, lesions that closely simulate malignant neoplasms are also described and illustrated. Also included are the giant cell neoplasms and the gastrointestinal stromal tumours as well as the new subtypes of carcinomas such as large cell neuroendocrine carcinomas and adenocarcinomas with pyloric gland or foveolar phenotype. The role of immunohistochemistry in the diagnosis of a wide variety of neoplasms is emphasised as well. This book will be a great resource to practicing pathologists and students for years to come.

Highly illustrated and conveniently templated for quick reference, Atlas of Liver Pathology, 4th Edition, is a useful Atlas and text for every practicing pathologist or trainee who assesses liver biopsy specimens. From cover to cover, it contains all the information needed to identify histologic features and correlate them with clinical findings, offering a clearer understanding of the clinical implications of the disease as it relates to treatment. More than 1,200 high-quality, full-color images and illustrations provide you with a complete visual guide to the vast majority of liver diseases and assist in the diagnoses of biopsy and resected liver specimens. Provides clear, templated information for each disease: Major Morphologic Features; Special Stains; Differential Diagnoses; Clinical and Biologic Behavior; and Treatment and Prognosis.  Incorporates relevant data from ancillary techniques (immunohistochemistry, cytology, cytogenetics and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology.  Incorporates the latest diagnostic biomarkers and their utility in differential diagnoses, newly described variants, and new histologic entities.  Contains two new chapters on liver biopsy interpretation and autoimmune hepatitis.  Features concise, bulleted text and abundant tables that cover common as well as rare diseases, differential diagnoses, and more.  An eBook version is included with purchase. The eBook allows you to access all of the text, tables, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. 

The authors of this volume have put emphasis on diagnosis, so the presentation is generally concise, yet more comprehensive on key points. In addition, they emphasise diagnostically-important information on immunohistochemistry and molecular genetics, and include additional details when biologically significant. Site-specific soft tissue entities covered in the other atlases are often excluded due to space constraints. The text is aimed as a practical diagnostic aid for pathologists, cytopathologists and pathology trainees, but the authors hope that their clinical colleagues and others may also find it as a useful source of information on soft tissue tumours and tumour-like lesions.

In the years since the publication of the third edition, awareness of the remarkable morphologic diversity of thyroid carcinoma has notably expanded, and great advances have been made in unravelling the molecular genetic features of thyroid and parathyroid tumours. There has also been an increased interest in the use of the fine-needle aspiration technique for the diagnosis and management of thyroid tumours, and in the role of the pathologist in the operative handling of the hyperfunctioning parathyroid gland. This volume documents the most significant advances that have taken place since the previous edition, emphasising those with a practical application at the clinical level. The format remains similar to that of the previous versions, but the two thyroid and parathyroid editions have been merged into one, and most of the black and white images and photomicrographs have been replaced with colour. The authors include a number of the most recent references, but have not ignored the classic works in the field, many of which have descriptions, illustrations, and insights that cannot be bettered. This edition fulfils the original goal of this series, which is that of helping the pathologist diagnose and anticipate the behavior of the tumours and tumour-like lesions included in this publication.

Comprehensive, concise, and superbly illustrated, Weedon's Skin Pathology Essentials, 3rd Edition, provides expert, easy-to-read guidance on key diagnoses in dermatopathology for pathologists and dermatologists in practice and training. This clearly written, well-structured text/atlas is ideal for quickly looking up practical problems in the recognition and diagnosis of skin lesions both clinically and histologically. Cross-referenced to the encyclopedic and authoritative Weedon's Skin Pathology, 5th Edition, it enables you to avoid pitfalls and make the most accurate diagnoses with confidence. Covers more than 1,300 dermatopathological entities, both common and rare, including additional entries in every section of the text. Provides more than 3,000 color histopathologic and clinical images for complete visual coverage of key diagnostic points for any given entity, and features new illustrations of rare conditions and unusual manifestations. Includes numerous summary tables and diagnostic algorithms that guide you to the most likely diagnosis and set of differential diagnoses for numerous inflammatory and neoplastic skin conditions. Discusses the latest immunohistochemical staining techniques and molecular genetic techniques. Uses a highly templated, bulleted, outline format throughout, facilitating quick and easy retrieval of key information. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Recent advances in computational algorithms, along with the advent of whole slide imaging as a platform for embedding artificial intelligence (AI), are transforming pattern recognition and image interpretation for diagnosis and prognosis. Yet most pathologists have just a passing knowledge of data mining, machine learning, and AI, and little exposure to the vast potential of these powerful new tools for medicine in general and pathology in particular. In Artificial Intelligence and Deep Learning in Pathology, Dr. Dr. Stanley Cohen, with a team of experts, covers the nuts and bolts of all aspects of machine learning, up to and including AI, bringing familiarity and understanding to pathologists at all levels of experience. Focuses heavily on applications in medicine, especially pathology, making unfamiliar material accessible and avoiding complex mathematics whenever possible. Covers digital pathology as a platform for primary diagnosis and augmentation via deep learning, whole slide imaging for 2D and 3D analysis, and general principles of image analysis and deep learning. Discusses and explains recent accomplishments such as algorithms used to diagnose skin cancer from photographs, AI-based platforms developed to identify lesions of the retina, using computer vision to interpret electrocardiograms, identifying mitoses in cancer using learning algorithms vs. signal processing algorithms, and many more.

For more than 45 years, Muscle Biopsy: A Practical Approach has offered, comprehensive, clinically-focused coverage of the acquisition, interpretation, and assessment of muscle biopsies - an area often only lightly covered in pathology texts. Taking an integrated approach that includes clinical, genetic, biochemical, and pathological features, the 5th Edition covers the full range of muscle disease in both adults and children. This highly illustrated, easy-to-use volume helps you navigate this challenging area, bridging the gap between clinical syndromes/disorders and their underlying pathologies. Fully updated 5th edition of this internationally acclaimed classic in muscle pathology. Written by internationally recognized world leaders in the field of muscle pathology. Comprehensive coverage of histology, histochemistry, immunocytochemistry and electron microscopy in parallel with clinical and genetic advances. Lavishly illustrated with over 600 full colour images. Fully updated literature review. Comprehensive update on the rapidly expanding field of neuromuscular disorders. 4th edition Highly Commended in Pathology category of the prestigious 2014 BMA Medical Book Awards. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

Intraoperative Frozen Sections presents diagnostic challenges involved in the evaluation in the pathology lab of specimens obtained during surgery through the case experience of expert pathologists. Sixty three problems cover the wide range of approximately of problems encountered in intraoperative consultations. Each presentation provides the case information as presented to the consultant, the evaluation and analysis of the specimen, discussion of the results and teaching points observed in the case, and an overall comment providing additional context for the diagnostic problem that has been presented. This problem-oriented format makes the book a superb reference resource for the working diagnostician and an ideal teaching tool for the resident or fellow. Coverage includes paediatric specimens and there is a section describing recognition of artifacts. Each case presentation is supported by several high-quality colour photomicrographs with detailed explanations of each image, including images of the permanent sections and immunostains where applicable. Features of Intraoperative Frozen Sections Include: Cases outline expert approach to diagnostic problems and technical issues most likely to be encountered in frozen section analysis. Coverage includes pediatric specimens and recognition of artifacts. Special emphasis on difficult problems and avoiding diagnostic pitfalls. Provides common differential diagnoses for specific lesions seen in frozen section analysis (e.g. mimics of renal neoplasia). Nearly 500 high-quality colour photomicrographs and detailed discussions of diagnostic features of each image.

This atlas describes the histologic changes relevant to the modern practice of forensic pathology. It guides the reader through the common questions that the forensic pathologist will need to answer in relation to the cause of death, such as: is this feature artifact or is this real? What does this signify? How old is this injury? The book focuses on key issues of forensic importance - e.g. sudden death, environmental deaths, injury timing and suspected child abuse. The book is highly illustrated with color photographs to increase the understanding of changes related to disease, decomposition and artifact. All illustrations are also available on a CD-ROM packaged with the print book. Ideal as a source of quick reference next to the microscope, this is essential reading for forensic pathologists, forensic pathology fellows, pathologists who consult in forensic cases, pathology residents, autopsy pathologists, coroners and forensic investigators.

A major revision of the leading textbook of FNA cytology Both text and illustrations provide a systematic and logical approach to the acquisition, interpretation and diagnosis of Fine Needle Aspirate biopsy specimens. Orell's FNA Cytology will assist in establishing diagnostic criteria and results in the examination of benign and malignant condition in all body systems where the technique is currently applied. The information is always presented in a clinical context: it details the role of FNA and other ancillary techniques in the investigative sequence (the cytological findings are always set in the context of the patient's clinical history, physical exam and other laboratory tests). It gives practical, technical advice on how to obtain good smears and alerts the reader as to possible diagnostic pitfalls and complications. The contents are organized in a framework of anatomical regions (rather than histopathological classifications) in order to reflect the way problems present in clinical practice. Each chapter is divided into two parts: the first deals with indications, accuracy, techniques and complications; the second illustrates the cytological patterns and their implication. Both common and rare conditions are covered.Provides practical tips and advice on how to avoid pitfalls and ensure accurate diagnoses. Over 1,200 colour illustrations capture each entity's cellular, morphological and immunohistochemical appearance. Chapters have been up-dated and revised and a brand new one on cytological findings in infectious diseases added. Both MGG and Pap smears illustrated in parallel as well as the corresponding histology to help provide side-by-side analysis. Access the full text online and download images via Expert Consult. Brand new chapter on cytological findings in infectious diseases. Inclusion of immuno-profiles and other relevant ancillary tests. New illustrations. New contributing authors. Available online via Expert Consult.

Alopecia areata is an unpredictable disorder that affects more than two and a half million men, women, and children in the United States and Canada. Causing patchy hair loss on the scalp and sometimes elsewhere on the body, this mysterious, noncontagious condition can be treated but it cannot yet be cured. Alopecia Areata: Understanding and Coping with Hair Loss is a sensitive yet straightforward guide to the diagnosis and treatment of this poorly understood disease. With great compassion, the authors explain how hair loss can profoundly affect a person's quality of life. They discuss what it means to be diagnosed with alopecia areata, and provide medically reliable information on the latest research, diagnosis, and treatment options.

Thompson and Shapiro also offer practical strategies for living with alopecia areata, which can go in and out of remission without any apparent reason. They discuss the physical and psychological adjustments to wearing a hairpiece and give pointers on selecting, securing, and maintaining a wig, whether human hair or synthetic, custom or ready-made. Alopecia Areata includes a chapter devoted to the special needs of children with this condition and concludes with an epilogue that tells the story of a day in the life of a woman with alopecia areata, illustrating the various challenges she faces and the strategies she uses to cope with these challenges.

"The book is an excellent source of information about the disease and the roller coaster emotional ride that usually accompanies it... A pleasure to read because of its intimate style and humor. It will go a long way in helping those with alopecia areata." -- Vera H. Price, M.D., professor ofdermatology, University of California, San Francisco

This concise introduction to pathology covers basic pathological mechanisms and offers a detailed review of systems pathology, making it a complete, effective review for today's readers. Hundreds of high-quality images-many new to this edition-illustrate common entities, and associated captions provide key pathological points. Reader-friendly text clarifies basic and complex information, helping you understand challenging concepts more easily. Wheater's Pathology is an excellent companion resource for users of Wheater's Functional Histology, 6th Edition, offering a comparison of normal histology with the pathological changes in disease. Contains a new chapter, Introduction to Pathology and Techniques, that provides more background information on histology techniques, immunohistochemistry, molecular tests and digital pathology. Contains new, full-color illustrations that depict additional pathological entities and update classifications. Includes access to online-only material such as new questions for each chapter, and numerous macroscopic images. Incorporates cutting-edge information on molecular pathology throughout. Includes quick-reference features such as keys to the lettering in images at the bottom of each page and fully revised clinical boxes with clinical-pathological correlations that explain the relevance of the pathological processes underlying common diseases and their complications. Summarizes key points with chapter reviews at the end of each section. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book is a practical guide to histopathological and cytopathological techniques for disease detection and diagnosis. Divided into fifteen chapter, the text begins with an overview of cells and tissue, discussion on microscopy, and an introduction to the importance of histopathology. The following sections cover different techniques, each describing basic theory, procedure, potential difficulties, and then concluding with important subjective and objective questions. Recent developments in the field including immunochemistry, automation, and microarray, are also discussed. Each technique is explained with the help of diagrams and figures to assist understanding. Key points Practical guide to histopathological and cytopathological techniques Presented in a step by step approach, with illustrative diagrams and figures Discusses recent advances and procedures Includes chapter on safety in the histopathology laboratory

An easily comprehensible and practicable framework for standardised histopathology reports in surgical cancer. The pathological features of the common carcinomas are detailed and non-carcinomatous malignancies are also summarised. 7th edition TNM and WHO classifications of cancers are incorporated, with comments on any associated pathology, diagnostic clues and prognostic criteria supplemented visually by line diagrams. Each chapter's introduction gives epidemiological, clinical, investigative and treatment summary details. Other pathology includes updated immunophenotypic expression and molecular techniques. The impact of these ancillary investigations on diagnosis, and as biomarkers of prognosis and prediction of response to treatment is summarised, as is the effect of adjuvant treatments on cancers. Experience based clues are given throughout as aids to tumour typing, grading, staging, and gauging prognosis and response to treatment. Histopathology Reporting: Guidelines for Surgical Cancer, Third Edition is invaluable for trainee and consultant diagnostic histopathologists all over the world, equipping the reader to produce high quality, clinically appropriate histopathology reports, and to participate in contemporary multidisciplinary team management of patients with surgical cancer.