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Histological Typing of Tumours of the Exocrine Pancreas (Paperback, Softcover reprint of the original 2nd ed. 1996)
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Histological Typing of Tumours of the Exocrine Pancreas (Paperback, Softcover reprint of the original 2nd ed. 1996)
Series: WHO. World Health Organization. International Histological Classification of Tumours
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This is a histological classification of tumours and tumour-like
lesions of the exocrine pancreas which also includes those tu-
mours showing a mixture of exocrine and endocrine elements. The
classification is based principally on standard microscopic
observations, but whenever indicated it incorporates diagnosti-
cally valuable immunohistological findings. In addition, the most
important immunohistological findings which are helpful in cat-
egorizing pancreatic tumours are summarised in Table 1. The major
guideline of this classification scheme is the group- ing of the
pancreatic exocrine tumours according to their biologi- cal
behaviour. Thus, the neoplasms are broadly divided into benign
(adenoma) and malignant tumours (carcinoma). How- ever, in recent
years we have learned that this division is not a sharp but rather
a gradual transition. We therefore added a third group which we
call "tumours of uncertain malignant potential" representing a
borderline category analogous to that recognized for some ovarian
tumours. This group includes mucinous cystic tumour, intraductal
papillary-mucinous tumour and solid- pseudopapillary tumour. These
neoplasms are defined by the grade of dysplasia and/or potential to
become malignant. Mucinous cystic tumours of uncertain malignant
potential, for instance, exhibit moderate epithelial dysplasia, but
do not show severe dysplasia/carcinoma in situ changes, nor
carcinomatous invasion of the cyst wall or the adjacent pancreatic
tissue. Solid- pseudopapillary tumour has a benign looking
histological ap- pearance, but metastases may occur. Biologically,
all these neoplasms are primarily slow-growing lesions and have an
excel- lent prognosis when adequately treated by complete
resection.
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