The Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry examines the drug discovery process, assessing how new technologies have improved effectiveness. Artificial intelligence and machine learning are considered the future for a wide range of disciplines and industries, including the pharmaceutical industry. In an environment where producing a single approved drug costs millions and takes many years of rigorous testing prior to its approval, reducing costs and time is of high interest. This book follows the journey that a drug company takes when producing a therapeutic, from the very beginning to ultimately benefitting a patient's life. This comprehensive resource will be useful to those working in the pharmaceutical industry, but will also be of interest to anyone doing research in chemical biology, computational chemistry, medicinal chemistry and bioinformatics.

Database technology can be used for various ends, ranging from promotion of democracy to strengthening of nationalism to shoring up authoritarian regimes through misinformation. Its use affects every layer of society: from individuals to households to local governments, and is a consuming issue in the United States Governments stance on privacy, security, and technology.

Healthcare Information Systems and Informatics: Research and Practices compiles estimable knowledge on the research of information systems and informatics applications in the healthcare industry. This book addresses organizational issues, including technology adoption, diffusion, and acceptance, as well as cost benefits and cost effectiveness, of advancing health information systems and informatics applications as innovative forms of investment in healthcare. Rapidly changing technology and the complexity of its applications make this book an invaluable resource to researchers and practitioners in the healthcare fields.

Enterprise Systems have been used for many years to integrate technology with the management of an organization but rapid technological disruptions are now creating new challenges and opportunities that require urgent consideration. This book reappraises the implementation and management of Enterprise Systems in the digital age and investigates the vital link between business processes, information technology and the Internet for an organization's competitive advantage and success. This book primarily focuses on the implementation, operation, management and integration of Enterprise Systems with fastemerging disruptive technologies such as blockchains, big data, cryptocurrencies, artificial intelligence, cloud computing, data mining and data analytics. These disruptive technologies are now becoming mainstream and the book proposes several innovations that organizations need to adopt to remain competitive within this rapidly changing landscape. In addition, it examines Enterprise Systems, their components, architecture, and applications and enlightens readers on the benefits and shortcomings of implementing them. This book contains primary research on organizations, case studies, and benchmarks ERP implementation against international best practice.

Acclaimed by various content platforms (books, music, movies) and auction sites online, recommendation systems are key elements of digital strategies. If development was originally intended for the performance of information systems, the issues are now massively moved on logical optimization of the customer relationship, with the main objective to maximize potential sales. On the transdisciplinary approach, engines and recommender systems brings together contributions linking information science and communications, marketing, sociology, mathematics and computing. It deals with the understanding of the underlying models for recommender systems and describes their historical perspective. It also analyzes their development in the content offerings and assesses their impact on user behavior.

Before the integration of expert systems in biomedical science, complex problems required human expertise to solve them through conventional procedural methods. Advancements in expert systems allow for knowledge to be extracted when no human expertise is available and increases productivity through quick diagnosis. Expert System Techniques in Biomedical Science Practice is an essential scholarly resource that contains innovative research on the methods by which an expert system is designed to solve complex problems through the automation of decision making through the use of if-then-else rules rather than conventional procedural methods. Featuring coverage on a broad range of topics such as image processing, bio-signals, and cognitive AI, this book is a vital reference source for computer engineers, information technologists, biomedical engineers, data-processing specialists, medical professionals, and industrialists within the fields of biomedical engineering, pervasive computing, and natural language processing.

One aspect of common sense reasoning is reasoning about normal cases, e.g. a physician will first try to interpret symptoms by a common disease, and will take more exotic possibilities only later into account. Such "normality" can be encoded, e.g. by
a relation, where case A is considered more normal than case B. This gives a standard semantics or interpretation to nonmonotonic reasoning (a branch of common sense reasoning), or, more formally, to nonmonotonic logics. We consider in this book the repercussions such normality relations and similar
constructions have on the resulting nonmonotonic logics, i.e. which types of logic are adequate for which kind of relation, etc.
We show in this book that some semantics correspond nicely to some logics, but also that other semantics do not correspond to any logics of the usual form.
Key features:
- provides a coherent picture of several formalisms of nonmonotonic logics.
- gives completeness and incompleteness results for many variants of preferential, distance based, and other semantics.
- gives probably the first systematic investigation of definability preservation and its consequences.
- gives new proof techniques for completeness results.
- is centered on semantics

This book is a timely collection of chapters that present the state of the art within the analysis and application of big data. Working within the broader context of big data, this text focuses on the hot topics of social network modelling and analysis such as online dating recommendations, hiring practices, and subscription-type prediction in mobile phone services. Manuscripts are expanded versions of the best papers presented at the IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining (ASONAM'2016), which was held in August 2016. The papers were among the best featured at the meeting and were then improved and extended substantially. Social Network Based Big Data Analysis and Applications will appeal to students and researchers in the field.

Intelligent methods are used in distributed environments in countless ways, with examples such as propagation, communication, collaboration, and cooperation. With the abundant purposes for intelligence in distributed systems, it is pertinent for researchers, technicians, and students in various areas of computer science to discover the most current and definitive advances in the field.""Intelligence Integration in Distributed Knowledge Management"" provides recent technologies and practices in intelligence for distributed systems, while covering major aspects of the agent based systems. This book is a must for those striving to enhance their understanding of distributed knowledge management and extend their ideas of cooperation using for numerous real-world problems.

In real management situations, uncertainty is inherently present in decision making. As such, it is increasingly imperative to research and develop new theories and methods of fuzzy sets. Theoretical and Practical Advancements for Fuzzy System Integration is a pivotal reference source for the latest scholarly research on the importance of expressing and measuring fuzziness in order to develop effective and practical decision making models and methods. Featuring coverage on an expansive range of perspectives and topics, such as fuzzy logic control, intuitionistic fuzzy set theory, and defuzzification, this book is ideally designed for academics, professionals, and researchers seeking current research on theoretical frameworks and real-world applications in the area of fuzzy sets and systems.

This book explores recent perspectives on type-2 fuzzy sets. Written as a tribute to Professor Jerry Mendel for his pioneering works on type-2 fuzzy sets and systems, it covers a wide range of topics, including applications to the Go game, machine learning and pattern recognition, as well as type-2 fuzzy control and intelligent systems. The book is intended as a reference guide for the type-2 fuzzy logic community, yet it aims also at other communities dealing with similar methods and applications.

This book details some of the major developments in the implementation of compressive sensing in radio applications for electronic defense and warfare communication use. It provides a comprehensive background to the subject and at the same time describes some novel algorithms. It also investigates application value and performance-related parameters of compressive sensing in scenarios such as direction finding, spectrum monitoring, detection, and classification.

At the centre of the methodology used in this book is STEM learning variability space that includes STEM pedagogical variability, learners' social variability, technological variability, CS content variability and interaction variability. To design smart components, firstly, the STEM learning variability space is defined for each component separately, and then model-driven approaches are applied. The theoretical basis includes feature-based modelling and model transformations at the top specification level and heterogeneous meta-programming techniques at the implementation level. Practice includes multiple case studies oriented for solving the task prototypes, taken from the real world, by educational robots. These case studies illustrate the process of gaining interdisciplinary knowledge pieces identified as S-knowledge, T-knowledge, E-knowledge, M-knowledge or integrated STEM knowledge and evaluate smart components from the pedagogical and technological perspectives based on data gathered from one real teaching setting. Smart STEM-Driven Computer Science Education: Theory, Methodology and Robot-based Practices outlines the overall capabilities of the proposed approach and also points out the drawbacks from the viewpoint of different actors, i.e. researchers, designers, teachers and learners.

This book summarizes the new research results presented at the 12th Joint Conference on Knowledge-Based Software Engineering (JCKBSE 2018), which took place on August 27-30, 2018 on the island of Corfu, Greece. The JCKBSE is a well-established international biennial conference that focuses on the applications of Artificial Intelligence in Software Engineering. The JCKBSE 2018 was organized by the Department of Informatics of the University of Piraeus, the Department of Computer and Information Engineering of Nippon Institute of Technology, and the Department of Informatics of Ionian University. The book will benefit not only experts and researchers in the field of (Knowledge-Based) Software Engineering, but also general readers in the fields of Artificial Intelligence, Computational Intelligence and Computer Science who wish to learn more about the field of (Knowledge-Based) Software Engineering and its applications. An extensive list of bibliographic references at the end of each paper encourages readers to probe further into the application areas that interest them most.

The most thrilling and challenging intellectual issues of humanity - whether and how a consistent account of reality can be obtained, which field of knowledge is capable to deal with the whole of reality and its formal representation, and how powerful intelligent machines can be brought into existence - are research areas demanding innovative and comprehensive study.""Reality, Universal Ontology and Knowledge Systems: Toward the Intelligent World"" provides cutting-edge research on reality, its nature and fundamental structure, and how it may be effectively represented both by human minds and intelligent machines. Striving to describe a standard world model and universal formal ontology, it offers a uniformly organized human knowledge. It includes powerful reasoning systems, and secure communication interoperability between two species of intelligences, as well as existing human beings and nascent computing reasoning systems promising the profound revolution in human values and ways of life.

This book provides an overview of the problems involved in engineering scalable, elastic, and cost-efficient cloud computing services and describes the CloudScale method - a description of rescuing tools and the required steps to exploit these tools. It allows readers to analyze the scalability problem in detail and identify scalability anti-patterns and bottlenecks within an application. With the CloudScale method, software architects can analyze both existing and planned IT services. The method allows readers to answer questions like: * With an increasing number of users, can my service still deliver acceptable quality of service? * What if each user uses the service more intensively? Can my service still handle it with acceptable quality of service? * What if the number of users suddenly increases? Will my service still be able to handle it? * Will my service be cost-efficient? First the book addresses the importance of scalability, elasticity, and cost-efficiency as vital quality-related attributes of modern cloud computing applications. Following a brief overview of CloudScale, cloud computing applications are then introduced in detail and the aspects that need to be captured in models of such applications are discussed. In CloudScale, these aspects are captured in instances of the ScaleDL modeling language. Subsequently, the book describes the forward engineering part of CloudScale, which is applicable when developing a new service. It also outlines the reverse and reengineering parts of CloudScale, which come into play when an existing (legacy) service is modified. Lastly, the book directly focuses on the needs of both business-oriented and technical managers by providing guidance on all steps of implementing CloudScale as well as making decisions during that implementation. The demonstrators and reference projects described serve as a valuable starting point for learning from experience. This book is meant for all stakeholders interested in delivering scalable, elastic, and cost-efficient cloud computing applications: managers, product owners, software architects and developers alike. With this book, they can both see the overall picture as well as dive into issues of particular interest.

The universe is a massive system of systems - for example, ecological systems, social systems, commodity and stock markets. These systems are complex, constantly adapting to their environment, and many are essential to the very existence of human beings. To fully understand these systems, complex adaptive systems research uses systemic inquiry to build multi-level and multidisciplinary representations of reality to study these systems.""Applications of Complex Adaptive Systems"" provides a global view of the most up-to-date research on the strategies, applications, practice, and implications of complex adaptive systems, to better understand the various critical systems that surround human life. Researchers working in the field of complex adaptive systems and related fields such as machine learning and artificial intelligence, multi-agent systems, and data mining, as well as professionals in related applications such as defense, bioinformatics, and sociology will find this book an indispensable, state-of-the-art reference.

This volume presents a process for developing expert systems. As the field of instructional technology matures it is becoming clear that technological process, not technological devices, is the single most important factor in designing effective instruction. Computers as devices are helpful, but their primary advantage may be the discipline placed on thinking and design processes by using them. The process used when examining a problem determines the quality of information entered into a program and the ultimate effectiveness of the solution. The process in this volume is intended for small-scale expert system solutions that contribute to the solution of instructional problems. Hardware independent, the volume focuses on narrowly defined examples intended for small personal computer systems. Particular attention is paid to problems associated with education and training.

"Building Expert Systems in Training and Education" has one primary function: to help instructional designers derive the components of a problem and enter it into an expert system shell. It is totally process-oriented and focuses on the front-end knowledge engineering process. It provides a repertoire of practical tools and processes that can be used to select, define, and structure problems. Three types of examples are used to illustrate three ways to use expert systems: for instructional support, for instructional decision making, and for an instructional job aid. Each chapter is followed by a list of learning activities to facilitate practice and consolidation. When appropriate, answers or examples to the learning activities is given. This is a practical guide for instructional technology educators and students, and business and industrial training professionals.

This book highlights recent research advances in unsupervised learning using natural computing techniques such as artificial neural networks, evolutionary algorithms, swarm intelligence, artificial immune systems, artificial life, quantum computing, DNA computing, and others. The book also includes information on the use of natural computing techniques for unsupervised learning tasks. It features several trending topics, such as big data scalability, wireless network analysis, engineering optimization, social media, and complex network analytics. It shows how these applications have triggered a number of new natural computing techniques to improve the performance of unsupervised learning methods. With this book, the readers can easily capture new advances in this area with systematic understanding of the scope in depth. Readers can rapidly explore new methods and new applications at the junction between natural computing and unsupervised learning. Includes advances on unsupervised learning using natural computing techniques Reports on topics in emerging areas such as evolutionary multi-objective unsupervised learning Features natural computing techniques such as evolutionary multi-objective algorithms and many-objective swarm intelligence algorithms

This book gathers a selection of the best papers presented during the 14th International Conference on Location Based Services, which was held in Zurich (Switzerland) between the 15th and 17th January 2018. It presents a general overview of recent research activities related to location based services. Such activities have grown in importance over the past several years, especially those concerning outdoor/indoor positioning, smart environments, spatial modeling, personalization and context-awareness, cartographic communication, novel user interfaces, crowdsourcing, social media, big data analysis, usability and privacy.

Ontologies form an indispensable basis for modeling and engineering languages for business enterprise and information systems: fostering a need for the integration of structural and behavioral aspects in domain-oriented ontologies.

Including contributions from leading experts in the field, this book covers applications and developments of heuristic search methods for solving complex optimization problems. The book covers various local search strategies including genetic algorithms, simulated annealing, tabu search and hybrids thereof. These methods have proved extraordinarily successful by solving some of the most difficult, real-world problems. At the interface between Artificial Intelligence and Operational Research, research in this exciting area is progressing apace spurred on by the needs of industry and commerce. The introductory chapter provides a clear overview of the basic techniques and useful pointers to further reading and to current research. The second section of the book covers some of the most recent and exciting developments of the basic techniques, with suggestions not only for extending and improving these but also for hybridizing and incorporating automatic adaption. The third section contains a number of case studies, surveys and comparative studies which span a wide range of application areas ranging from the classic Steiner tree problem to more practical problems arising in telecommunications and data analysis. The coverage of the latest research and the illustrative case studies will ensure that the book is invaluable for researchers and professionals with an interest in heuristic search methods.

The goal of this book is to crystallize the emerging mobile computing technologies and trends into positive efforts to focus on the most promising solutions in services computing. Many toys built today are increasingly using these technologies together and it is important to understand the various research and practical issues. The book will provide clear proof that mobile technologies are playing an ever increasing important and critical role in supporting toy computing, which is a new research discipline in computer science. It is also expected that the book will further research new best practices and directions in toy computing. The goal of this book is to bring together academics and practitioners to describe the use and synergy between the above-mentioned technologies. This book is mainly intended for researchers and students working in computer science and engineering, and for toy industry technology providers, having particular interests in mobile services. The wide range of authors of this book will help the various communities understand both specific and common problems. This book facilities software developers and researchers to become more aware of this challenging research opportunity. As well, the book is soliciting shall provide valuable strategic outlook on the emerging toy industry.