The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.

This edited volume brings together the state of the art in polymer nanocomposite theory and modeling, creating a roadmap for scientists and engineers seeking to design new advanced materials. The book opens with a review of molecular and mesoscale models predicting equilibrium and non-equilibrium nanoscale structure of hybrid materials as a function of composition and, especially, filler types. Subsequent chapters cover the methods and analyses used for describing the dynamics of nanocomposites and their mechanical and physical properties. Dedicated chapters present best practices for predicting materials properties of practical interest, including thermal and electrical conductivity, optical properties, barrier properties, and flammability. Each chapter is written by leading academic and industrial scientists working in each respective sub-field. The overview of modeling methodology combined with detailed examples of property predictions for specific systems will make this book useful for academic and industrial practitioners alike.

Challenged by stringent regulations, vigorous competition, and liability lawsuits, medical device manufactures must develop safe, reliable, and cost-effective products, and managing and reducing risk is a vital element of reaching that goal. These guidelines focus on Failure Modes and Effects Analysis (FMEA) and its application throughout the life cycle of a medical device. It outlines the major U.S. and E.U. standards and regulations and provides a detailed yet easy-to-read overview of risk management and risk analysis methodologies, common FMEA pitfalls, and FMECA-Failure Mode, Effects, and Criticality Analysis.

Guidelines for Failure Modes and Effects Analysis for Medical Devices is written as a practical guide to achieving corporate consistency while dramatically cutting the time required for studies. It will help you prevent patient injuries, costly product recalls, and production department down-time.

Discover how the FMEA methodology can help your company achieve a more cost-effective manufacturing process by improving the quality and reliability of your products. This new FMEA manual from the experts at Dyadem is the ultimate resource for you and your colleagues to learn more about Failure Modes and Effects Analysis and then teach others at your facility. This comprehensive manual is sure to become a standard reference for engineering professionals.

This volume studies, in chronological order, three types of large clocks-wall, cabinet and free-standing, with particular attention to clocks from France, England, Holland, Scandinavia and the German-speaking countries. The emphasis is on French clocks due to recent great interest in the trade of these among collectors. The English clocks, still favored by a large group of collectors, are strongly represented here and there are several beautiful examples from Holland. The German speaking area, including Austria, Germany, and Switzerland are also well represented especially with clocks from south Germany-a delight for lovers and collectors of the Baroque and Rocco clocks. European Pendulum Clocks is essential for the collector of clocks, dealers, auction houses, museums, and anyone awed by the beauty and craftsmanship of these fascinating timepieces.

Force and Position Control of Mechatronic Systems provides an overview of the general concepts and technologies in the area of force and position control. Novel ideas and innovations related to this area are presented and reported in detail, and examples of applications in medical technology are given. The book begins by introducing force sensing, and modelling of contacting objects. In then moves steadily through a variety of topics, including: * disturbance observer-based force estimation; * force-based supervisory control; * stabilization systems; * controller design; and * control of tube insertion procedures. This book will be of interest to researchers, engineers and students interested in force control, particularly those with a focus on medical applications of these ideas. Advances in Industrial Control reports and encourages the transfer of technology in control engineering. The rapid development of control technology has an impact on all areas of the control discipline. The series offers an opportunity for researchers to present an extended exposition of new work in all aspects of industrial control.

Wireless Sensor Networks presents a comprehensive and tightly organized compilation of chapters that surveys many of the exciting research developments taking place in this field. Chapters are written by several of the leading researchers exclusively for this book. Authors address many of the key challenges faced in the design, analysis and deployment of wireless sensor networks. Included is coverage of low-cost sensor devices equipped with wireless interfaces, sensor network protocols for large scale sensor networks, data storage and compression techniques, security architectures and mechanisms, and many practical applications that relate to use in environmental, military, medical, industrial and home networks. The book is organized into six parts starting with basic concepts and energy efficient hardware design principles. The second part addresses networking protocols for sensor networks and describes medium access control, routing and transport protocols. In addition to networking, data management is an important challenge given the high volumes of data that are generated by sensor nodes. deals with security protocols and mechanisms for wireless sensor networks. Sensor network localization systems and network management techniques are covered in Part V. The final part focuses on target detection and habitat monitoring applications of sensor networks. This book is intended for researchers starting work in the field and for practitioners seeking a comprehensive overview of the various aspects of building a sensor network. It is also an invaluable reference resource for all wireless network professionals.

This informative book compiles the most up-to-date applications of nanobiosensors in fields ranging from agriculture to medicine. The introductory section describes different types of nanobiosensors and use of nanobiosensors towards a sustainable environment. The applications are divided into four broad sections for easy reading and understanding. The book discusses how manipulation, control and integration of atoms and molecules are used to form materials, structures, devices and systems in nano-scale. Chapters in the book shed light on the use of nanosensors in diagnostics and medical devices. Application in food processing as well as in cell signaling is also described. Nanobiosensors have immense use, and this book captures the most important ones.

Discusses the industry transformation aligned with computerization of manufacturing and the concept of required skills needed to build the new workforce Covers the role of Artificial Intelligence in the management of resource flow and decision-making in the industrial transformation of operations and supply chain management Presents sustainability efficiency for industrial transformation with IoT, machine learning, data analysis and blockchain technologies Focuses on industrial development, design, implementation, and transformation using technologies such as Big Data Analytics, Blockchain among others Showcases the incorporation of complex processes and functions as one central component of digital systems Explores current trends that are accelerating the industrial transformation and influencing the transition of the fourth industrial revolution related to industrial infrastructure, biodiversity, and production enhancement

This dictionary, specific to lean business processes, contains over 500 terms used in lean management and manufacturing.

Easy to access, accurate, and comprehensive, "LeanSpeak" will become the desktop tool of choice for lean manufacturing practitioners, from the shop floor to the corner office.

"Here are some examples of entries in LeanSpeak: "

gemba: Japanese word of which the literal translation is "the real place." In the manufacturing field, gemba means the shop floor, where the actual product is being made, as contrasted to the office, where support services are provided.

lean: shorthand to refer to a lean manufacturing system, of which the Toyota Production System is the foremost example, that has relatively little non-value-adding waste and maximum flow. The term has been used pejoratively to refer to anti-labor practices intending to reduce the number of workers within a company and to strong-arm tactics with suppliers.

takt time: the rate at which product must be turned out to satisfy market demand. It is determined by dividing the available production time by the rate of customer demand. For example, if customers demand 240 widgets per day and the factory operates 480 minutes per day, takt time is two minutes. If customers want two new products designed per month, takt time is two weeks. It is a calculated number, not a reflection of your capability. It sets the pace of production to match the rate of customer demand.

Also available as an ebook in Microsoft Reader, Adobe Acrobat Reader, or Palm Reader formats.

This book gives an overview of nanostructures and nanomaterials applied in the fields of energy and organic electronics. It combines the knowledge from advanced deposition and processing methods of nanomaterials such as laser-based growth and nanopatterning and state-of-the-art characterization techniques with special emphasis on the optical, electrical, morphological, surface and mechanical properties. Furthermore it contains theoretical and experimental aspects for different types of nanomaterials such as nanoparticles, nanotubes and thin films for organic electronics applications. The international group of authors specifically chosen for their distinguished expertise belong to the academic and industrial world in order to provide a broader perspective. The authors take an interdisciplinary approach of physics, chemistry, engineering, materials science and nanotechnology. It appeals to researchers and graduate students.

The packaging industry is under pressure from regulators, customers and other stakeholders to improve packaging's sustainability by reducing its environmental and societal impacts. This is a considerable challenge because of the complex interactions between products and their packaging, and the many roles that packaging plays in the supply chain. Packaging for Sustainability is a concise and readable handbook for practitioners who are trying to implement sustainability strategies for packaging. Industry case studies are used throughout the book to illustrate possible applications and scenarios. Packaging for Sustainability draws on the expertise of researchers and industry practitioners to provide information on business benefits, environmental issues and priorities, environmental evaluation tools, design for environment, marketing strategies, and challenges for the future.

This book covers remarkable contemporary nanomaterials such as carbon nanomaterials, nanoclays, quantum dots, MXene, and metal-organic frameworks. Each chapter discusses the synthesis techniques, characterization methods, properties, and the nanomaterials' use in different aspects of biomedical, energy, polymers, material construction, biosensors, coatings, and catalysis. Moreover, commercialization challenges and environmental risks of nanomaterials are also covered in depth. The book provides an understanding of the fundamental properties, limitations and challenges in nanomaterials synthesis, serving as a valuable resource for researchers, graduate students, academicians, and consultants working with nanomaterials for engineering applications.

This book highlights a novel and holistic approach to multiscaled PVA bionanocomposite films used for electrical sensing, medical and packaging applications. With a combination of material characterization and modeling to understand the effect of nanoparticle size and shape, as well as 3D interphase properties and features such as interphase modulus and nanoscale dimensions, this book substantiates how excellent mechanical and thermal properties of these materials are achieved. Also it addresses the importance of using economical and ecofriendly bionanocomposites as potential green materials to support the goal of environmental sustainability with multifunctional properties.

This book highlights the main advances in fiber electronics, like fiber-shaped solar cells, batteries, supercapacitors, sensors, light-emitting devices, memristors and communication devices from the standpoints of material synthesis, structure design and property enhancement. It focuses on revealing the separation and transport mechanisms of charges, establishing transport equations for electrons and ions, and emphasizing integration methods in fiber devices. In closing, it reviews emerging applications based on fiber devices that could accelerate their large-scale production in the near future. Given its scope, the book offers a valuable resource for scientists, engineers, graduate students and undergraduate students in a wide variety of fields such as advanced materials, energy, electrochemistry, applied physics, nanoscience and nanotechnology, polymer science and engineering and biomedical science. It also benefits many non-specialist industrialists who are working to promote new technologies.

This book introduces a passivity-based approach which simplifies the controller design task for AC-motors. It presents the application of this novel approach to several classes of AC motors, magnetic levitation systems, microelectromechanical systems (MEMS) and rigid robot manipulators actuated by AC motors. The novel passivity-based approach exploits the fact that the natural energy exchange existing between the mechanical and the electrical subsystems allows the natural cancellation of several high order terms during the stability analysis. This allows the authors to present some of the simplest controllers proposed in scientific literature, but provided with formal stability proofs. These simple control laws will be of use to practitioners as they are robust with respect to numerical errors and noise amplification, and are provided with tuning guidelines. Energy-based Control of Electromechanical Systems is intended for both theorists and practitioners. Therefore, the stability proofs are not based on abstract mathematical ideas but Lyapunov stability theory. Several interpretations of the proofs are given along the body of the book using simple energy ideas and the complete proofs are included in appendices. The complete modeling of each motor studied is also presented, allowing for a thorough understanding. Advances in Industrial Control reports and encourages the transfer of technology in control engineering. The rapid development of control technology has an impact on all areas of the control discipline. The series offers an opportunity for researchers to present an extended exposition of new work in all aspects of industrial control.

This book provides a single-source reference on carbon nanotubes for interconnect applications. It presents the recent advances in modelling and challenges of carbon nanotube (CNT)-based VLSI interconnects. Starting with a background of carbon nanotubes and interconnects, this book details various aspects of CNT interconnect models, the design metrics of CNT interconnects, crosstalk analysis of recently proposed CNT interconnect structures, and geometries. Various topics covered include the use of semiconducting CNTs around metallic CNTs, CNT interconnects with air gaps, use of emerging ultra low-k materials and their integration with CNT interconnects, and geometry-based crosstalk reduction techniques. This book will be useful for researchers and design engineers working on carbon nanotubes for interconnects for both 2D and 3D integrated circuits.

Digital Twin Driven Smart Service draws on the latest industry practice and research to explain how to implement digital twin service in a range of scenarios. It addresses relevant theory and methodologies, including product service, prognostic health management service, energy efficient service and testing service. Other sections discuss key enabling technologies supported by cutting-edge case studies of implementation. Drawing on the work of researchers at the forefront of this technology, this book is the ideal guide for anyone interested in product services, manufacturing services and digital twin services. This book is one part of a trilogy on digital twins, the other titles being Digital Twin Driven Smart Design and Digital Twin Driven Smart Manufacturing.

Thin Film Magnetoresistive Sensors presents a comprehensive review of thin film magnetoresistive (MR) sensors, including the theory of MR effects as well as the design, fabrication, properties, and applications of MR sensors. With over 1,000 references, the book fully reviews the theory, development, and use of these sensors. It provides essential information about the performance of various kinds of sensors, including permalloy magnetoresistors, spin valve sensors, multilayer sensors, colossal effect sensors, spin dependent tunneling sensors, and magnetoimpedance sensors.
Divided into three independent parts, the book first concentrates on the most widely used sensors-anisotropic magnetoresistive sensors (AMR). The second part deals with giant magnetoresistive (GMR) sensors, including those still in development. In the third section, the book describes the applications of MR sensors, especially in data storage systems, industrial measurements, and nondestructive material testing systems.

Saddle up for adventure with the horse-and-rider sets by Hartland Plastics, the small midwestern company that set a standard of excellence for mass produced, plastic figurines. Whether you like horses; collect toys, model horses, TV mementos or Western memorabilia; or just want to recall the days when heroes were good guys on horseback, this book will make you smile. Hartland Plastics manufactured about six dozen riders and 10 standing gunfighters, over 100 horses for the riders, and countless miniature accessories--and the fun they had shows. The quality sculpture by Roger Williams and Alvar Backstrand and fine attention to painted details give Hartland models a place in the history of American toys and the hearts of kids and collectors. Hartland expert Gail Fitch has assembled a guide loaded with color photography and valuable information for the collector, including current prices, data tables, and advice on care and repair of your models.

This book gathers the latest advances, innovations, and applications in the field of multibody and mechatronic systems. Topics addressed include the analysis and synthesis of mechanisms; dynamics of multibody systems; design algorithms for mechatronic systems; robots and micromachines; experimental validations; theory of mechatronic simulation; mechatronic systems for rehabilitation and assistive technologies; mechatronic systems for energy harvesting; virtual reality integration in multibody and mechatronic systems; multibody design in robotic systems; and control of mechatronic systems. The contents reflect the outcomes of the 7th International Symposium on Multibody Systems and Mechatronics (7th MuSMe) in 2020, within the framework of the FEIbIM Commission for Robotics and Mechanisms and IFToMM Technical Committees for Multibody Dynamics and for Robotics and Mechatronics.

This is the Participant Guide to support team leaders in implementing an autonomous maintenance team. This is usually sold with Autonomous Maintenance: Shopfloor TPM Implementation. This is for extra copies.

ReducedEffort (R) Changeover: The Lean Way to Quickly Reduce Changeover Downtime provides a step-by-step guide for conducting a Kaizen event that empowers the people who do the work to improve how that work is done. Packed with tips, tools, and examples, this practical guide begins with a clear description of the Lean principles underlying the ReducedEffort Changeover system. In addition, it explains how and why reducing the effort always reduces the time of converting a machine, line, or process from one product to another. In this book, you'll find everything you need to quickly and dramatically reduce the effort and time of any process using the ReducedEffort method. This is not another book about how to do SMED. Like SMED, ReducedEffort Changeover (REC) does reduce changeover time, but REC is not SMED. SMED, Single Minute (or digit) Exchange of Dies, developed by Dr. Shigeo Shingo, has been the process used for many years by countless manufacturing plants to reduce changeover time. The SMED process was used in Toyota to reduce the changeover of a 1,000-ton stamping press from four hours to three minutes. As a Lean-based process, the REC system focuses on reducing the labor, not the time, involved in changing over a machine to work on a different product. With REC, there are no Standard Operation Combination Sheets to fill out and no Problem Identification Sheets to complete, and it does not require the arduous chore of timing every task, as SMED does. Very little capital investment is required with REC. Unlike SMED, it does not require management-approved funding to achieve substantial results. Because REC is not capital-driven, management does not need to drive the process. The operators will drive the process because it reduces their labor. One of the biggest advantages of REC over SMED is that operators will readily accept the process, and more important, they will want to sustain it. The reason for this is quite simple and will become evident when the REC process is defined. REC takes SMED to a new level that is easier and faster both to implement and to deliver sustainable results.

This book brings together investigations which combine theoretical and experimental results related to such systems as flexure hinges and compliant mechanisms for precision applications, the non-linear analytical modeling of compliant mechanisms, mechanical systems using compliance as a bipedal robot and reconfigurable tensegrity systems and micro-electro-mechanical systems (MEMS) as energy efficient micro-robots, microscale force compensation, magnetoelectric micro-sensors, acoustical actuators and the wafer bonding as a key technology for the MEMS fabrication. The volume gathers twelve contributions presented at the 5th Conference on Microactuators, Microsensors and Micromechanisms (MAMM), held in Ilmenau, Germany in November 2020. The aim of the conference was to provide a special opportunity for a know-how exchange and collaboration in various disciplines concerning systems pertaining to micro-technology. The conference was organized under the patronage of IFToMM (International Federation for the Promotion of Mechanism and Machine Science).

This book is an effort to tether all the exuberant observations on adding nanomaterial in the TPE matrix. With an enhanced processing property along with amplified recyclability and reprocessing feature, thermoplastic elastomers (TPE) proves to be one of the most significant polymeric materials till date. As the scientific world evolves, these advanced materials have attuned themselves with various anisotropic nanomaterials to induce an enhanced property effect on the final product. On an additional note, authors have done extensive research on graphene, the most multifaceted element in the filler family keeping TPE and its derivate as the matrix martial. Cogitating the idea of a multidimensional readership, authors have analyzed the synthesis, derivatization, and properties of graphene and its derivatives separately. Apart from reviewing the future prospects and the potential application of these nano-filled advanced materials, they have kept the structure-property relationship of graphene-based composites at the cynosure to provide firm understanding on the blossoming of these elastomeric composites. The authors believe this book is a potential content for both professionals and academicians.

This book includes representative research from the state-of-the-art in the emerging field of soft robotics, with a special focus on bioinspired soft robotics for underwater applications. Topics include novel materials, sensors, actuators, and system design for distributed estimation and control of soft robotic appendages inspired by the octopus and seastar. It summarizes the latest findings in an emerging field of bioinspired soft robotics for the underwater domain, primarily drawing from (but not limited to) an ongoing research program in bioinspired autonomous systems sponsored by the Office of Naval Research. The program has stimulated cross-disciplinary research in biology, material science, computational mechanics, and systems and control for the purpose of creating novel robotic appendages for maritime applications. The book collects recent results in this area.