An easy to follow step-by-step guide to the most useful surgical skills from knot tying to simple procedures. Illustrated with colour photographs and video clips to demonstrate techniques, this book makes these practical skills as clear and easy to follow as possible. Including coverage of surgical instruments, wound management and suturing, and minor surgical procedures, it also explains how to use these essential surgical skills to make the most of a surgical placement. Healthcare students or junior professionals undertaking a placement in surgery or emergency medicine will feel confident and capable, and will be able to take an active role in surgical placements. Learning basic surgical skills is important for such placements, as well as for undertaking exams such as the Membership of the Royal College of Surgeons (MRCS).

Through case presentations and a question and answer format," Clinical Decisions in Nephrology, Hypertension and Renal Transplantation" provides a state of the art, updated reference for the optimal management of patients with diseases of the kidneys, and hypertension. This volume starts with the assessment of the patient, focusing on history and physical examination. Subsequently, cases depicting various clinical syndromes and/or diseases are presented, with questions centering on the appropriate diagnostic and treatment strategy. This sets the stage for a Socratic approach to learning between the attending physician and the house staff or medical student.

This is the only book featuring problem-oriented true to life clinical cases in this format to cover nephrology, hypertension and kidney transplantation. Written by renowned actively practicing clinicians, this unique reference is both comprehensive and concise and will be of great value to hospitalists and internists, as well as students, and interns/residents rotating in nephrology and internal medicine.Clinical practitioners, in the fields of critical care and hypertension specialists would also find this of value."

IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney. This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life and the correlation with renal carcinogenesis. Written by well recognized experts in their fields, Kidney Development in Renal Pathology is a valuable tool for pathologists, neonatologists, nephrologists, gynecologists and researchers with an interest in kidney diseases.

Few complications of systemic diseases are better understood than diabetic nephropathy. In large part, progress in this area is due to Carl Erik Mogensen's steadfast preoccupation over more than three decades with the disorder's epidemiology, pathogenesis, pathophysiology, clinical diagnosis and evolving strategies of management. Though he sparked progress in each of these areas, he generously opens the forum of discussion to many expert contributors to this latest and most comprehensive edition of this exemplary textbook. In eliciting all relevant and up-to-date views, the reader, whether internist, pediatrician or specialist in endocrinology or nephrology, is assured a thorough review of the entire subject and in a format which is exceptionally well-written, well-illustrated and easy to read. Each of the prior editions have been an essential resource for my own work in this field and the 5th edition will no doubt continue to provide the information I and others will require to move forward in the years ahead. If only the other renal diseases were as masterfully synthesized, how much easier our task would be of achieving a comprehensive vision of all else in clinical nephrology. Barry M. Brenner, M.D., Samuel A. Levine Professor of Medicine, Harvard Medical School

For today's nephrologist who is tasked with diagnosing a wide range of renal pathologic entities, Diagnostic Atlas of Renal Pathology is a must-have reference for everyday use. The updated 4th Edition offers an in-depth examination of pathophysiology, clinical presentations, and the latest evidence-based practices. Hundreds of pertinent macro- and/or microscopic images are presented in a user-friendly manner intended specifically for renal pathology. Offers templated, detailed discussions on key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information for each disorder. Features numerous tables and sidebars with key points and differential diagnoses. Covers major new advances in the classification and diagnosis of select tubular cystic diseases, new advances in classification of fibrillary processes and C3 related diseases, new insights in monoclonal protein-related diseases, ongoing work in lupus, and advances in IgA nephropathy as well as transplantation. Contains more than 700 high-quality representative images of light, immunofluorescence, and electron microscopy, including new colorized electron microscopy images, with correlations to clinical presentation and pathogenesis. Features new animations that clearly depict the progression of membranous nephropathy, membranoproliferative GN, and crescentic GN. Includes schematic representations of glomerular diseases, which are particularly useful for illustrating difficult concepts. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

In consultation with Consulting Editor, Dr. Stephen Krau, Dr. Farrar and Dr. Ellison have created an issue that focuses on evidence-based clinical updates and innovations in various nephrology disorders. Top experts on the topic have contributed reviews on the follwoing topics: Kidney Influence on Fluids and Electrolytes; Renal Diet; Pharmacologic Renal Therapy; Acute Renal Therapy; Chronic Renal Therapy; Innovations in Kidney; Autoimmune Disease; Infection-Related Glomerular Disease; Sclerotic Diseases; Obstructive Renal Diseases; Chronic Renal Complications; Psychosocial Issues and Life Style Changes for the Renal Patient; and Withdrawal of Treatment (end of life decisions). Authors will come away with the clinical knowledge they need to improve outcomes in the nephrotic patient.

The 1991 International Yearbook of Nephrology is the third in a sueeessful .eries whieh has, as its principal aim, thc presentation of a eomprehensive list of topfes of the greatest current relevanee to elinieal nephrologists. We believe that, by following the subjeets eovered by the Yearbook in the broad field of nephrology, the praetieing nephrologist and nephrologist-in-training ean stay abreast of a number of rapidly advaneing fields. To improve the quality of the Yearbook, we have appointed an Editorial Board to provfde suggestions for topies and authors. Thus, we have invited 58 outstanding nephrologists from around the world (the list of them is included in this issue of the Yearbook) to identify annually potential topies for the Yearbook. The reply was exeel lent and the contribution quite outstanding. Thus, for the 1992 Yearbook, we reeeived more than 150 suggestions. A number of them will be included in the next issue if they continue to be viewed as eurrent and important. We also invite readers to suggest topies for upeoming issues of the Yearbook. The present issue, the 1991 Yearbook, represents an improvement over previous volumes. We expeet this trend to be maintained in future years. As in previous issues, all ehapters provide a eomplete, aeeurate and up-to-date list of important references. We are grateful to all the authors for their exeellent eontributions and for having fulfilled the deadline in forwarding their manuseript. Our special thanks to Kluwer Aeademie Publishers for the timely publieation of this volume."

This volume includes all procedures and practices relating to the selection of organ donors, removal of organs, preservation and allocation for a successful transplantation. The improving preservation solutions as well as the improving survival rates of transplant patients should make it a useful book on all aspects of transplantation. The chapters are divided into four sections: donor conditioning and surgery; organ preservation; allocation and logistics; ethics and legislation in organ donation. The growing awareness of the need for organ donation and adaptation of laws, as well as the increasing efforts of the transplantation organizations to stimulate organ donation, makes this text a timely publication. This book is aimed at medical specialists in any hospital involved, or potentially involved, in organ procurement, transplant co-ordinators and administrators, transplant surgeons, nephrologists and other organ specialists and researchers. The chapters on surgical techniques are illustrated with original artwork by Bernard Tardieu.

This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Acute Renal Failure in Practice, edited by practising renal physicians, is the essential guide to the clinical management of patients with acute renal failure and its complex, life-threatening metabolic sequelae. This book explains the workings of the normal kidney, illustrates the aetiology and pathophysiology of acute renal disease, and provides practical treatment guidelines relevant to the day-to-day needs of the practising clinician. There is a clear emphasis on the underlying pathogenic mechanisms naturally leading to a full understanding of the rationale behind the recommended treatments. Each chapter is illustrated throughout by coloured tables and diagrams, and incorporates unique easy-to-follow "practice points" algorithms which detail, step-by-step, the precise treatment protocols required to succeed in caring for these complex patients. An entire section is dedicated to dealing with patients who develop acute renal failure in specific hospital settings, such as the labour ward or intensive care unit. Doctors working in a wide range of acute medical specialities frequently encounter patients with acute renal failure and will therefore find this an invaluable clinical handbook.

This second edition of the Manual of Clinical Dialysis is a concise and well-illustrated guide to all aspects of dialysis. All chapters have been revised and present a complete overview of the techniques, processes and equipment involved in clinical dialysis as well as an overview of the complications of dialysis. The manual also provides an overview of common clinical problems related to renal failure such as hypertension, anemia and renal osteodystrophy.

This unique volume may very well foreshadow the treatment of renal disease in the twenty-first century. The editors have obviously compiled and reviewed the current clinical problems in which the kidney plays a major role. They then selected as topics for chapters those in which recent scientific investigations have added significant new data. The investigators themselves or their peers have been persuaded to produce a summary of current concepts of renal structure and function for each topic. The result is a volume which will be as invaluable as a clinical guide on the laboratory bench as it will be a reference for the clinician seeking guidance to rational therapy at the bedside. The strength of the volume lies in the incorporation of those data on renal cellular structure and function which hold the key to the etiology of the majority of renal diseases we now call 'end-stage'. Fully, two-thirds of the volume is devoted to current concepts of renal function and related subcellular structure of various renal tissues. The illustrations, correlations, and explanations are superbly presented in much detail and with an obvious effort to fill out the current knowledge of each subject. We may anticipate this book will remain a valuable reference for many years to come.

Textbook of Nephro-Endocrinology, Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypocalcemia and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid-base disturbances, and pregnancy.

This textbook provides a broad review of kidney diseases with regard to symptoms, investigation and treatment. It deals with a variety of clinical entities, such as glomerulonephritis, renal stones, hypertension, urinary infection and renal failure. Chapters on dialysis and transplantation highlighting local incidence and statistics are included. The current concepts and therapies of kidney diseases as well as the latest statistics on kidney diseases are also covered. In this edition, the author has incorporated the results of recent clinical trials in renal therapeutics into various chapters of the book, and provided abstracts and references where relevant.Presently, there are several books on the market written by authors in the West, but they do not adequately cover the knowledge and experience of the patterns of renal diseases in the Asia-Pacific region.Written in a clear and concise style, Clinical Nephrology will serve as an invaluable practical guide for medical students and doctors preparing for their higher examinations.

The Guest Editors have secured the top urologists to provide current clinical reviews on the latest advances in the management of small renal masses. Articles are devoted to the following topics: hereditary yndromes; trends in renal surgery; humor anatomic complexity; risk assessment; renal biopsy; active surveillance; ablation; surgical techniques; renal ischemia; lymph node dissection; complications; neoadjuvant targeted therapy for renal surgery; salvage surgery; and post-operative surveillance. Readers will come away with a succinct overview of the most clinically relevant articles and be able to immediately implement the clinical information in their practice.

Chronic Kidney Disease in Disadvantaged Populations investigates the increased incidence and prevalence of kidney disease in vulnerable populations world-wide. The volume explores the complex interactions of genetic, biologic, cultural and socioeconomic factors such as the environment, and specific health behaviors that seem to be responsible for a significant proportion of the health disparities in these communities. Each chapter is written by leading experts in the field and analyzes the prevalence and incidence of pre-dialysis kidney disease in disadvantaged populations across both developed and developing countries. In addition, each contribution analyzes differentiated risk factors and compares the disparities in access to screening, prevention strategies, treatment protocols and renal replacement therapies. Chronic Kidney Disease in Disadvantaged Populations is essential reading for residents, fellows, clinicians and biomedical researchers working in nephrology, internal medicine, and epidemiology, especially those working in areas with high concentrations of disadvantaged populations.

A distinguished panel of world authorities reviews the current state of today's understanding, diagnosis, and treatment of pancreatic cancer. Their cutting-edge reviews discuss both medical and surgical modalities and include numerous insights into the basic molecular processes underlying the disease. Among the key topics covered are the prospects for early diagnosis using molecular techniques, the latest diagnostic and therapeutic methods, the role of laparoscopy (diagnostic and therapeutic), and nonsurgical treatment. The reviewers also address the future possibilities for clinical advances, quality of life concerns, and the value of the Japanese "extended Whipple resection." Pancreatic Cancer will become the new standard reference for all clinicians who diagnose and treat this disease, as well as for basic scientists needing a summary of the many recent advances.
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We are pleased to present to our readers the proceedings of the Fourth Bari Seminars in Nephrology. The Topic of these proceedings deals with tubulo- interstitial nephropathies. The Bari Seminars in nephrology are bi-annual meetings attended by a large international audience comprised of clinician-scientists in the various disci- plines of nephrology and related fields. We trust that our readers will find the content of these proceedings reward- ing and interesting. We are indebted for the generous financial support of the Centro Nationale delle Richerche, Italy. Alberto Amerio Pasquale Coratelli Shaul G. Massry TUBULO-INTERSTITIAL NEPHROPATHIES 1 STRUCTURAL, ASPECTS OF THE RENAL INTERSTITIUM W.KRIZ AND K.V. LEMLEY Institute of Anatomy and Cell Biology, University of Heidelberg, D-6900 Heidelberg 1, F.R.G. Childrens Hospital of Los Angeles, Division of Nephrology, Los Angeles, U.S.A. The interstitium of the kidney includes the extravascular inter- tubular spaces of" the renal parenchyma, with their attendant cellular elements and extracellular substances. It is bounded on all sides by tubular and vascular basement membranes. The lymphatics are considered as part of the interstitium.

A number of remarkable recent breakthroughs have made the study of nitric oxide one of the most exciting fields in physiology and pathophysiology. This authoritative edited volume reviews the progress to date and opens perspectives to novel diagnostic and therapeutic strategies. The contributors are leading authorites, in most cases the investigators who have pioneered the ideas explored in the book.

This work gives an introduction to all aspects of drug use in renal failure."Introduction to Renal Therapeutics" is an introduction to all aspects of drug use in renal failure. Covering various diseases affecting the kidneys, each chapter discusses the disease process and treatment. It also addresses the role of the pharmacist in patient care. Case studies and questions and answers are included at the end of each chapter.Written by members of the UK Renal Pharmacy Group, this book will be of particular interest to anyone new to, or planning a career in, renal pharmacy. It will also be of interest to nonspecialists who deal with renal patients and to pharmacy students, and to any healthcare professional with an interest in renal medicine.

Since the mid 1990s, transplantation knowledge and techniques, as well as insights into pharmacology, have improved, thus enabling greater access to transplantation for patients. The pool of organs for transplantation is stable, and therefore insufficient to cope with the growing demand. To adjust demand and resources in the most equitable way, organ procurement and allocation have been organized nationally and often across borders. The national and international organ exchange programmes were studied and discussed during the Congress on Organ Allocation, from which this book is derived. This book describes the state of the art in the management of waiting lists and the allocation of organs in transplantation. It includes chapters on the possibilities of expanding the pool of available cadaver organs. It also analyzes the results of transplantation of cadaver organs from older donors and marginal, non-heart-beating donors. Transplantation policies based on the offering of organs by living donors are also described, as is the impact of delayed graft function on organ allocation.

This text is part of the Continuing Education series, organized by Fondation Marcel Merieux and Universite Claude Bernard in Lyon where the annual subject is chosen to reflect the status of the topical issues of the year, as taught by leading international experts. The contribution of transplantation and clinical immunology to advanced medicine is considerable and promising. The annual volumes in this series keep the reader abreast of these developments in the field.

Thistranslational textoffers in-depth reviews of the metabolic and nutritional disorders that are prevalent in patients with renal disease. Chapter topics address the growing epidemic of obesity and metabolic syndrome. Each chapterintegrates basic and clinical approaches, from cell biology and genetics to diagnosis, patient management and treatment. Chapters in sections 4-7include new illustrative case reports, and all chaptersemphasize key concepts with chapter-ending summaries. New featuresalso include the latest National Kidney Foundation Clinical Practice Guidelines on Nutrition in Chronic Renal Failure, the most recent scientific discoveries and the latest techniques for assessing nutritional status in renal disease, and literature reviews on patients who receive continuous veno-venous hemofiltration with or without dialysis.
Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to discuss the underlying research and translation of best practices for the nutritional management and prevention of renal diseaseSaves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles.

Correct diagnosis (and therefore correct treatment) of renal, metabolic, and nutritional disorders depends on a strong understanding of the molecular basis for the disease both nephrologists and nutritionists will benefit

Nephrologists and nutritionists will gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient

Case Reports will offer an added resource for fellows, nutritionists, and dieticians who need a refresher course "