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Molecular Recognition of DNA Double Helix - Gene Regulation and Photochemistry of BrU Substituted DNA (Paperback, Softcover reprint of the original 1st ed. 2018)
Loot Price: R3,212
Discovery Miles 32 120
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Molecular Recognition of DNA Double Helix - Gene Regulation and Photochemistry of BrU Substituted DNA (Paperback, Softcover reprint of the original 1st ed. 2018)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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In this book, the molecular recognition of DNA using small
molecules is discussed, with a study of the photochemistry of
BrU-labeled DNA. The purposes of the study were to develop small
molecules for regenerative medicine, to develop a method to detect
the recognition site of small molecules, and to detect the most
important biological phenomena using the photochemistry of
BrU-labeled DNA. The study began with the design and development of
small molecules that can induce pluripotency genes. To deal with
the important issue of cell permeability of the original compound,
a new analogue of the original with improved gene expression was
designed and synthesized. Using the photochemistry of BrU-labeled
DNA, crucial biological phenomena such as cooperativity between
transcription factors were detected. For the first time, the
cooperativity was examined by excess electron transfer assay. DNA
was also studied very carefully in order to understand the
mechanism of the double-strand break in the UVA micro-irradiation
technique. The mechanism of the double strand remained untouched.
Nevertheless, the double-strand break mechanism was clearly
demonstrated by Hoechst dye, as shown in this book.
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