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Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
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Epilepsy and the Corpus Callosum (Paperback, Softcover reprint of the original 1st ed. 1985)
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Epilepsy and the Corpus Callosum (Paperback, Softcover reprint of the original 1st ed. 1985)
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Total price: R1,702
Discovery Miles: 17 020
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InJuly 1982 the first Dartmouth workshop on the corpus callosum
took place. A nucleus of basic and clinical scientists was convened
to give progress reports of their work on the corpus callosum. This
text was subsequently compiled by the various participants from
these reports modified by a stimulating cross fertilization of
ideas and subsequent studies. Four and one-half decades have
intervened since Van Wagenen first sectioned the corpus callosum
for epilepsy (Van Wagenen and Herren, 1940) and Erickson (1940)
demonstrated that the corpus callosum is the major route for
generalization of experimentally induced focal cortical epilepsy.
During the succeeding 45 years a handful of clinicians has pursued
these leads to confirm the therapeutic value of callosotomy for
some types of medically intractable generalized epilepsy. Parallel
experimental studies with a number of epilepsy models have
indicated that the corpus callosum is indeed the major route for
seizure generalization, that the brainstem is a secondary and more
resistant pathway for seizure generalization, and that most if not
all epileptic seizures originate from the cerbral cortex. The
unexpected clinical finding that even partial (focal) seizure
incidence is modified by callosotomy now has been demonstrated in
the laboratory. The various contributors to the clinical and
experimental epilepsy sections of this volume have been seminal in
these elucidations, as will be evident from their chapters. The
section on the development, anatomy, and physiology of the corpus
callosum demonstrates that these basic areas of study have not been
neglected.
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