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Poly(ADP-ribose) Polymerase - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011)
Loot Price: R3,407
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Poly(ADP-ribose) Polymerase - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2011)
Series: Methods in Molecular Biology, 780
Expected to ship within 10 - 15 working days
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Poly (ADP-ribose) Polymerases (PARPs) are abundant and ubiquitous
proteins that regulate crucial processes of the cell cycle, DNA
repair, genomic stability, and transcriptional regulation. Being
involved in basic cell functions, PARPs mediate rapid responses to
such environmental factors as stress, infection, nutrition and
hormonal signals. Whereas PARP inhibitors can suppress tumor growth
and proliferation in certain breast, ovarian, and prostate cancers,
understanding how PARP controls cellular functions is essential for
the development of novel cancer treatments strategies. Divided into
three convenient sections, Poly(ADP-Ribose) Polymerase: Methods and
Protocols aims to explain how PARP proteins act within the normal
development of an organism as well as in pathogenic conditions,
seeks to advance the knowledge of developmental pathways
regulation, and endeavors to facilitate the development of new
therapeutic drugs and methods to target PARP-dependent processes.
Written in the highly successful Methods in Molecular Biology (TM)
series format, chapters contain introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and notes
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Poly(ADP-Ribose) Polymerase: Methods and Protocols
serves as an ideal guide to scientists who wish to continue
exploring this exciting and progressive research field.
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