Muscarinic acetylcholine receptors have played a key role in the
advancement of knowledge of pharmacology and neurotransmission
since the inception of studies in these fields, and the effects of
naturally occurring drugs acting on muscarinic receptors were known
and exploited for both therapeutic and non-therapeutic purposes for
hundreds of years before the existence of the receptors themselves
was recognized. This volume presents a broad yet detailed review of
current knowledge of muscarinic receptors that will be valuable
both to long-time muscarinic investigators and to those new to the
field. It describes the detailed insights that have been obtained
on the structure, function, and cell biology of muscarinic
receptors. This volume also describes physiological analyses of
muscarinic receptors and their roles in regulating the function of
the brain and of a variety of peripheral tissues. This volume shows
how the study of muscarinic receptors continues to provide new and
surprising insights not just to the cholinergic system but to the
broad areas of neurobiology, cell biology, pharmacology, and
therapeutics.
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