Form and Function of Mammalian Lung: Analysis by Scientific Computing (Paperback, illustrated edition)

1.1 Overview The precise knowledge of the three-dimensional (3-D) assembly of biological structures is still in its origin. As an example, a widely accepted concept and common belief of the structure of the airway network oflung is that of a regular, dichotomous branching pattern, also known as the trumpet model. This model, first introduced by Weibel in 1963, is often used in clinical and physiological applications. However, if this concept of dichotomy is used to model lung, a shape is obtained that is quite different from a real lung. As a matter of fact, many previous quantitative morphological and stereological investigations of lung did not concentrate on the spatial aspect of lung morphology but delivered data in a more statistical fashion. Accordingly, the functional behavior predicted by such a model becomes questionable and indeed, the morphometrically predicted lung capacity exceeds the physiological required capacity by a factor of 1.3 up to a factor of2. This problem has also been termed a paradox, as discussed by Weibel in 1983. In the rare cases where descriptive models of the mammalian bronchial tree exist, monopodial in small mammals, dichotomous in larger ones, the understanding of the historical and/or functional reasons for size-related changes in the general design is not explainable. This investigation is trying to overcome this gap by computer modeling and functional simulation.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Advances in Anatomy, Embryology and Cell Biology, 145
Release date:	2001
First published:	October 1998
Authors:	Andres Kriete
Dimensions:	235 x 155 x 6mm (L x W x T)
Format:	Paperback
Pages:	108
Edition:	illustrated edition
ISBN-13:	978-3-540-64494-1
Categories:	Books > Computing & IT > General theory of computing > General Books > Computing & IT > Applications of computing > General Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal physiology Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Vertebrates > Mammals > General
LSN:	3-540-64494-6
Barcode:	9783540644941

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