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Bisphosphonates in Clinical Oncology - The Development of Pamidronate (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R2,741
Discovery Miles 27 410
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Bisphosphonates in Clinical Oncology - The Development of Pamidronate (Paperback, Softcover reprint of the original 1st ed. 1999)
Series: Recent Results in Cancer Research, 149
Expected to ship within 10 - 15 working days
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The book gives an overview of the clinical developments in the use
of bisphosphonates in clinical oncology. The first part pre sents
the composition, physiology, and pathophysiology of bone. Next is a
section giving insight into mechanisms of bone resorp tion, bone
formation, and bone remodeling, a field in which I was most
influenced by O. L. M. Bijvoet and H. Fleisch. The sec ond part
summarizes the pharmacological treatments for disor ders of bone
remodeling. The clinical aspects of tumor-induced hypercalcemia and
its management are described in detail, in cluding our first
prospective randomized crossover study testing pamidronate versus
mithramycin. The bisphosphonates were in troduced in clinical
oncology by endocrinologists. The same was true for our institution
in 1986, when P. Burckhardt proposed testing pamidronate in the
above-mentioned trial in his institu tion (CHUV) and in our
department. The impressive results ob tained in the hypercalcemia
trial stimulated our interest, and we actively investigated the use
of pamidronate to counteract osteo lytic bone destruction in cancer
patients. These investigations are presented and discussed in the
third part. They represent the interdisciplinary work involving
many co-workers of the Depart ment of Internal Medicine C and other
institutes of the Interdis ciplinary Oncology Center St. Gallen
(IOSG), which I was privi leged to chair for 10 years. Initially, a
pharmacokinetic study was performed in order to optimize and
facilitate the administration of the drug to patients with
malignant osteolytic bone disease."
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