Nitric Oxide as a Chemosensitizing Agent, Volume One is the first
book to describe several reviews by authoritative scientists and
clinicians on novel findings in the reversal of drug resistant
cancers by the combination treatment of Nitric Oxide and sub toxic
concentrations of chemotherapeutic drugs that have been reported in
both in vitro, in vivo and preclinical models. The book describes
the various underlying chemical, molecular and genetic mechanisms
by which NO and NO reactive species mediate the anti-cancer
activity, thus reducing the threshold of drug resistance and
enabling chemo therapeutic drugs to induce their cytotoxic activity
and reversal of resistance. This book exposes scientists and
clinicians to this highly beneficial topic for research
investigations and pharmaceutical companies to new avenues for
R&D. It is a valuable resource for cancer researchers,
oncologists and members of several areas of the biomedical field
who are interested in understanding how to use Nitric Oxide as a
sensitizing agent for chemotherapy.
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