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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Clinically Relevant Resistance in Cancer Chemotherapy (Paperback, Softcover reprint of the original 1st ed. 2002)
Loot Price: R2,992
Discovery Miles 29 920
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Clinically Relevant Resistance in Cancer Chemotherapy (Paperback, Softcover reprint of the original 1st ed. 2002)
Series: Cancer Treatment and Research, 112
Expected to ship within 10 - 15 working days
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Over the last several decades, the introduction of new
chemotherapeutic drugs and drug combinations has resulted in
increased long term remission rates in several important tumor
types. These include childhood leukemia, adult leukemias and
lymphomas, as well as testicular and trophoblastic tumors. The
addition of high-dose chemotherapy with growth factor and
hemopoietic stem cell support has increased clinical remission
rates even further. For the majority of patients with some of the
more common malignancies, however, palliation (rather than cure) is
still the most realistic goal of chemotherapy for metastatic
disease. The failure of chemotherapy to cure metastatic cancer is
commonly referred to among clinicians as "drug resistance". This
phenomenon can, however, often be viewed as the survival of
malignant cells that resulted from a failure to deliver an
effective drug dose to the (cellular) target because of anyone of
or combination of a multitude of individual factors. Clinically,
this treatment failure is often viewed as the rapid occurrence of
resistance at the single cell level. However, in experimental
systems, stable drug resistance is usually relatively slow to
emerge.
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