Presents an integrated view of the expression of bacterial genetic
information, genome architecture and function, and bacterial
physiology and pathogenesis This book blends information from the
very latest research on bacterial chromosome and nucleoid
architecture, whole-genome analysis, cell signaling, and gene
expression control with well-known gene regulation paradigms from
model organisms (including pathogens) to give readers a picture of
how information flows from the environment to the gene, modulating
its expression and influencing the competitive fitness of the
microbe. Structure and Function of the Bacterial Genome explores
the governance of the expression of the genes that make a bacterium
what it is, and updates the basics of gene expression control with
information about transcription promoter structure and function,
the role of DNA as a regulatory factor (in addition to its role as
a carrier of genetic information), small RNAs, RNAs that sense
chemical signals, ribosomes and translation, posttranslational
modification of proteins, and protein secretion. It looks at the
forces driving the conservation and the evolution of the dynamic
genome and offers chapters that cover DNA replication, DNA repair,
plasmid biology, recombination, transposition, the roles of
repetitive DNA sequences, horizontal gene transfer, the defense of
the genome by CRISPR-Cas, restriction enzymes, Argonaute proteins
and BREX systems. The book finishes with a chapter that gives an
integrated overview of genome structure and function. Blends
knowledge of gene regulatory mechanisms with a consideration of
nucleoid structure and dynamics Offers a 'DNA-centric' approach to
considering transcription control Views horizontal gene transfer
from a gene regulation perspective Assesses the opportunities and
limitations of designing synthetic microbes or rewiring existing
ones Structure and Function of the Bacterial Genome is an ideal
book for graduate and undergraduate students studying microbial
cell biology, bacterial pathogenesis, gene regulation, and
molecular microbiology. It will also appeal to principal
investigators conducting research on these and related topics and
researchers in synthetic biology and other arms of biotechnology.
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