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NMDA Antagonists as Potential Analgesic Drugs (Hardcover, 2002 ed.)
Loot Price: R3,184
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NMDA Antagonists as Potential Analgesic Drugs (Hardcover, 2002 ed.)
Series: Progress in Inflammation Research
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Total price: R3,204
Discovery Miles: 32 040
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Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp &
Dohme Research Laboratories, Neuroscience Research Centre, Terlings
Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a
distinct medical need for new pain therapies. Therefore, it is not
surprising that in recent years there has been a major research
initiative in both aca- demic and pharmaceutical laboratories to
identify novel pain targets and to devel- op novel analgesic drugs.
It is clear from numerous studies that the NMDA recep- tor plays a
major role in the transmission ofnociceptive information and it has
been a subject of extensive investigation over the last decade
exploiting the advances of molecular pharmacology and molecular
neuroanatomy. As a consequence there has been a rational approach
by several laboratories to develop receptor subtype-spe- cific NMDA
antagonists in order to avoid the wide range of side-effects seen
with non-selective NMDA ion channel antagonists such as ketamine.
This volume brings together contributions from experts in various
technological disciplines who have contributed immensely to NMDA
receptor research and advanced our understanding of the subunit
composition of the NMDA receptor complex, its pharmacology and
distribution, its interaction with other neurochemi- cal systems
and the effects on behaviour of NMDA antagonists in rodent models
and in the clinic. In consideration of these advances and the
prospects of novel NMDA receptor antagonists in the near future for
the treatment of pain, this vol- ume is very timely.
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