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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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The Adhesive Interaction of Cells, Volume 28 (Hardcover, Reissue ed.)
Loot Price: R2,927
Discovery Miles 29 270
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The Adhesive Interaction of Cells, Volume 28 (Hardcover, Reissue ed.)
Series: Advances in Molecular & Cell Biology
Expected to ship within 12 - 19 working days
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The aim of "The Adhesive Interaction of Cells" has been to assemble
a series of reviews by leading international experts embracing many
of the most important recent developments in this rapidly expanding
field. The purpose of all biological research is to understand the
form and function of living organisms and, by comprehending the
normal, to find explanations and remedies for the abnormal and for
disease conditions. The molecules involved in cell adhesion are of
fundamental importance to the structure and function of all
multicellular organisms. In this book, the contributors focus on
the systems of vertebrates, especially mammals, since these are
most relevant to human disease. It would have been equally possible
to concentrate on developmental processes and adhesion in lower
organisms.
A major function of adhesion molecules is to bind cells to each
other or to the extracellular matrix, but they are much more than
"glue." Adhesions in animal tissues must be dynamic-forming,
persisting, or declining in regulated fashion- to facilitate the
mobility and turnover of tissue cells. Moreover, the majority of
adhesion molecules are transmembrane molecules and thus provide
links between the cells and their surroundings. This gives rise to
another major function of adhesion molecules, the capacity to
transduce signals across the hydrophobic barrier imposed by the
plasma membrane. Such signal transduction is crucially important to
many aspects of cellular function including the regulation of cell
motility, gene expression, and differentiation.
The work in this book progresses through four sections. Part I
discusses the four major families of adhesion molecules themselves,
the integrins (Green and Humphries), the cadherins (Stappert and
Kemler), the selectins (Tedder et al.) and the immunoglobulin
superfamily (Simmons); part 2 considers junctional complexes
involved in cell interactions: focal adhesions and adherens
junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight
junctions (Citi and Cordenonsi). The signaling role of adhesion
molecules is the focus of part 3, through integrins and the
extracellular matrix (Edwards and Streuli), through platelet
adhesion (Du and Ginsberg), and in the nervous system (Hemperley).
In part 4, the aim is to show how adhesive phenomena contribute to
important aspects of cell behavior and human health. Leukocyte
trafficking (Haskard et al.), cancer metastasis (Marshall and
Hart), cell migration (Paleck et al.), and implantation and
placentation (Damsky et al.) are the topics considered in depth.
The different sections are, of course, not mutually exclusive: it
is both undesirable and impossible to separate structure from
function when considering cell adhesion. Each chapter has its
unique features, but some overlap is both invevitable and valuable
since it provides different perspectives on closely related topics.
We hope that the whole contributes a valuable and stimulating
consideration of this important topic.
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