A complete introduction and guide to the latest developments in
cancer gene therapy-from bench to bedside. The authors
comprehensively review the anticancer genes and gene delivery
methods currently available for cancer gene therapy, including the
transfer of genetic material into the cancer cells, stimulation of
the immune system to recognize and eliminate cancer cells, and the
targeting of the nonmalignant stromal cells that support their
growth. They also thoroughly examine the advantages and limitations
of the different therapies and detail strategies to overcome
obstacles to their clinical implementation. Topics of special
interest include vector-targeting techniques, the lessons learned
to date from clinical trials of cancer gene therapy, and the
regulatory guidelines for future trials. Noninvasive techniques to
monitor the extent of gene transfer and disease regression during
the course of treatment are also discussed.
General
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