This is a scientific and philosophical autobiography written around
a collection of Denis Noble's most significant papers. It traces a
remarkable journey from na ve reductionism to a rigorous systems
approach to living systems. It is rigorous because Denis Noble was
one of the first biologists to construct computer models of cells
and organs of the body. His theoretical work is entirely
mathematically based, with no room for ambiguity. Far from the
denigration of the systems approach as holistic 'hand-waving', his
work is now regarded by pharmaceutical companies and regulators as
the gold standard of modelling in the development of new
medication.
Systems Biology is an idea in search of a definition. This book
explains why this is true: it is an approach rather than a subject.
Denis Noble's work is one of the clearest examples of the systems
approach in practice since it reveals the nature of some of the
forms of downward causation in multilevel analysis. The story will
delight readers who like to see how scientific controversy is
resolved, since many of the developments described in each chapter
were highly controversial when they occurred.
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