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BCL-2 Family Proteins - Methods and Protocols (Hardcover, 1st ed. 2019)
Loot Price: R5,519
Discovery Miles 55 190
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BCL-2 Family Proteins - Methods and Protocols (Hardcover, 1st ed. 2019)
Series: Methods in Molecular Biology, 1877
Expected to ship within 10 - 15 working days
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Total price: R5,539
Discovery Miles: 55 390
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This volume explores numerous techniques for the genetic,
molecular, biochemical, and structural examination of BCL-2 family
proteins and their interactions. The chapters in this book cover
topics such as the relevance of BCL-2 proteins in health and
disease; evaluating cellular dependencies to specific BCL-2 family
proteins; flow-cytometry-based methods for measuring BCL-2 proteins
and mitochondrial-based cell death; measuring activity and
interactions of BCL-2 family proteins in the presence of
mitochondria, artificial membranes or yeast; conformational
activation and oligomerization of pro-apoptotic proteins BAX and
BAK leading to cytochrome c release and apoptosis; structural and
biophysical studies in solution and lipid vesicles using nuclear
magnetic resonance, cryo-electron microscopy, fluorescence
microscopy and electron paramagnetic resonance. Written in the
highly successful Methods in Molecular Biology series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls. Cutting-edge and thorough, BCL-2 Family
Proteins: Methods and Protocols is a valuable resource to inspire
and encourage novice and established scientists to further their
research and make new discoveries in this exciting field.
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