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Dietary Polyphenols - Metabolism and Health Effects (Hardcover)
Loot Price: R6,097
Discovery Miles 60 970
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Dietary Polyphenols - Metabolism and Health Effects (Hardcover)
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Presents recent research on metabolism and the health effects of
polyphenols Consumer interest in the health benefits of many
phenolic compounds found in plant foods and derivatives has grown
considerably in recent years, giving rise to an increased demand
for functional foods. Although preclinical and observational
studies have promoted the protective properties of polyphenols for
a range of chronic diseases, evidence has shown that most dietary
polyphenols have little bioavailability. Once ingested, most of
them are metabolized by either the intestinal enzymes or by the gut
microbiota and then undergo extensive phase-II metabolism reaching
significant concentrations of conjugated metabolites. They remain
in the systemic circulation and target systemic tissues where
trigger biological effects. The polyphenol-derived metabolites
produced in humans are dependent upon the composition of the gut
microbiota and the subject genetics. Thus all the metabolites do
not show the same biological activity in different individuals. To
fully understand the health effects of polyphenols, further
clinical investigations are required. Dietary Polyphenols describes
the latest findings on the polyphenol metabolism and reviews the
current evidence on their health effects and that of their
bioavailable metabolites. Emphasizing the importance of
interindividual variability and the critical role of gut
microbiota, this authoritative volume features contributions from
recognized experts in the field, exploring specific families of
extractable and non-extractable phenolic compounds that exhibit
potential health effects. Topics include structural diversity of
polyphenols and distribution in foods, bioavailability and
bioaccessibility of phenolics, metabolism, and gastrointestinal
absorption of various metabolites and their health effects. This
comprehensive volume: Discusses the bioavailability,
bioaccessibility, pharmacokinetics studies, and microbial
metabolism of different groups of phenolic compounds Examines the
interaction between polyphenols and gut microbiota Describes
analytical methods for identifying and quantifying polyphenols in
foods and biological samples Reviews recent epidemiological and
clinical intervention studies showing protective effects of
polyphenols Dietary Polyphenols: Metabolism and Health Effects is
an important resource for scientists working in the area of dietary
polyphenols and health effects, microbiota, and their interaction
with other nutritional compounds, and for health professionals,
nutritionists, dieticians, and clinical researchers with interest
in the role of polyphenols in the prevention and treatment of
chronic diseases.
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