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ADP-Ribosylation of Proteins - Enzymology and Biological Significance (Paperback, Softcover reprint of the original 1st ed. 1987)
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ADP-Ribosylation of Proteins - Enzymology and Biological Significance (Paperback, Softcover reprint of the original 1st ed. 1987)
Series: Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik, 37
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In 1966, a paper entitled "On the formation of a novel adenylylic
compound by enzymatic extracts of liver nuclei" from Paul Mandel's
laboratory in Strasbourg, France, planted the seed for a rapidly
growing new field of biological research focusing on
ADP-ribosylation reactions. The development of this field over the
past 2 decades reflects very much a modern trend of biological
research. As more detailed knowledge accumulates, enigmatic
phenomena turn into concepts which create their own enigmata. This
process tends to favor the development of multiple, seemingly
disconnected, research lines until simplicity emerges from chaos
and unifying concepts substitute for controversy. It appears that
the field of ADP-ribosylation reactions has not yet attained this
latter stage. For example, with the identification of two different
classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla tion
and poly-ADP-ribosylation reactions, the field split very early
into two separate branches of research. With the present volume, we
have divided the task of reviewing these two classes of ADP
ribosylation accordingly, although their coexistence in eukaryotes
may involve a closer functional linkage than hitherto recognized."
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