For the Editors, the task of writing a Preface is most satisfying.
It represents the completion of the book and a moment of reflection
on whether the whole is more than the sum of all the parts. And
also, one must reflect on how this book is likely to be utilized in
this era of rapid communications. The Editors first met in May 2003
at a stimulating Italian symposium on endometrial cancer
(organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni,
with participation of the deans of Italian Gynecologic Oncology,
Ugo Bianchi and Constantino Mangioni) that took place at Bergamo
and Caravaggio. The impressive gains in biology and clinical trials
were further discussed by the two editors and others that are
co-authors in this venture on this side of the Atlantic at a 2004
Educational Session at the American Society of Clinical Oncology
(ASCO). The pace of progress in various aspects of management of
uterine cancer was no- worthy, not only was tumor biology fueling
novel hypotheses such as questioning the mesenchymal origin of
carcinosarcomas, but knowledge of molecular pathways was beginning
to be applied as prognostic and as predictive factors portending
benefit from systemic therapies. Surgical staging and sensitive
imaging provided the underpinning for refining our treatment
algorithms. Finally, a role for che- therapy had finally become
established, principally through phase III studies c- paring
chemotherapy to radiation in mostly locally advanced stages III and
IV that had undergone resection.
General
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