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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Molecular Approaches to Heart Failure Therapy (Paperback, Softcover reprint of the original 1st ed. 2000)
Loot Price: R2,896
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Molecular Approaches to Heart Failure Therapy (Paperback, Softcover reprint of the original 1st ed. 2000)
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G. HASENFUSS, E. MARBAN Heart failure embodies the central irony of
modern medicine. As we have become increasingly adept at treating
the major proximate causes of death in Western society, we have
effectively converted acute illness into chronic malady. The last
twenty years have witnessed a revolution in the treatment of acute
coronary syndromes, myocardial infarction in particular. Patients
who reach the hospital now have every expectation of leaving alive,
but not necessarily well. Our ability to blunt the edge of ischemic
insults has en gendered new problems: a new cohort of patients
whose hearts function well enough to enable short-term survival,
but at the cost of decreased ex ercise tolerance, dyspnea and
increased long-term mortality. The irony is compounded by our
increasingly sophisticated pharmacopeia for the treat ment of heart
failure, which, by slowing the progression of ventricular dys
function, has created a chronic illness. The fact of its chronicity
makes heart failure no less deadly. In symptomatic patients,
mortality exceeds 5-10% per year even with the best contemporary
therapy. Not all heart failure is ischemic, of course, but the
final common phenotype is eerily concordant regardless of the
proximate cause. No wonder, then, that heart failure is the leading
cause of hospitalization in America and in Western Europe and that
the prevalence of the disease continues to rise. Drugs have indeed
revolutionized heart failure therapy, ACE inhibitors and
beta-adrenergic blockers having the most outstanding records to
date.
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