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The Biostatistics of Aging - From Gompertzian Mortality to an Index of Aging-Relatedness (Hardcover)
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The Biostatistics of Aging - From Gompertzian Mortality to an Index of Aging-Relatedness (Hardcover)
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A practical and clarifying approach to aging and aging-related
diseases Providing a thorough and extensive theoretical framework,
The Biostatistics of Aging: From Gompertzian Mortality to an Index
of Aging-Relatedness addresses the surprisingly subtlenotion with
consequential biomedical and public health relevance of what it
means for acondition to be related to aging. In this pursuit, the
book presents a new quantitative methodto examine the relative
contributions of genetic and environmental factors to mortality
anddisease incidence in a population. With input from evolutionary
biology, population genetics, demography, and epidemiology, this
medically motivated book describes an index of aging-relatedness
and also features: * Original results on the asymptotic behavior of
the minimum of time-to-event random variables, which extends those
of the classical statistical theory of extreme values * A
comprehensive and satisfactory explanation based on biological
principles of the Gompertz pattern of mortality in human
populations * The development of an evolution-based model of
causation relevant to mortality and aging-related diseases of
complex etiology * An explanation of how and why the description of
human mortality by the Gompertz distribution can be improved upon
from first principles * The amply illustrated analysis of
real-world data, including a program for conducting the analysis
written in the freely available R statistical software * Technical
appendices including mathematical material as well as an extensive
and multidisciplinary bibliography on aging and aging-related
diseases The Biostatistics of Aging: From Gompertzian Mortality to
an Index of Aging-Relatedness is an excellent resource for
practitioners and researchers with an interest in aging and
aging-related diseases from the fields of medicine, biology,
gerontology, biostatistics, epidemiology, demography, and public
health.
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