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De novo Molecular Design (Hardcover)
Loot Price: R3,570
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De novo Molecular Design (Hardcover)
Expected to ship within 9 - 15 working days
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Systematically examining current methods and strategies, this ready
reference covers a wide range of molecular structures, from
organic-chemical drugs to peptides, Proteins and nucleic acids, in
line with emerging new drug classes derived from biomacromolecules.
A leader in the field and one of the pioneers of this young
discipline has assembled here the most prominent experts from
across the world to provide first-hand knowledge. While most of
their methods and examples come from the area of pharmaceutical
discovery and development, the approaches are equally applicable
for chemical probes and diagnostics, pesticides, and any other
molecule designed to interact with a biological system. Numerous
images and screenshots illustrate the many examples and method
descriptions. With its broad and balanced coverage, this will be
the firststop resource not only for medicinal chemists, biochemists
and biotechnologists, but equally for bioinformaticians and
molecular designers for many years to come. From the content: *
Reaction-driven de novo design * Adaptive methods in molecular
design * Design of ligands against multitarget profiles * Free
energy methods in ligand design * Fragment-based de novo design *
Automated design of focused and target family-oriented compound
libraries * Molecular de novo design by nature-inspired computing *
3D QSAR approaches to de novo drug design * Bioisosteres in de novo
design * De novo design of peptides, proteins and nucleic acid
structures, including RNA aptamers and many more.
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