For many years the mammalian blood cell system has provided cell
biologists and haematologists with one of the best experimental
models in which to unravel how one stem cell -- the hematopoietic
stem cell -- gives rise to many different types of progeny.
Numerous models of lineage relationships have emerged, but the most
influential of these, in which differentiating cells undergo a
series of binary choices, has been increasingly challenged in
recent years -- to the extent that the accumulation of new findings
recently culminated in a Nature commentary suggesting that "the
latest research will necessitate revision of textbook accounts".
This book brings together contributions from many leading experts
in the field of blood cell development who each discuss both the
overall process of hematopoiesis and the origins and development of
each of the cells of the blood and immune systems. It describes how
new molecular, cellular and -- particularly -- transgenic tools are
helping us understand the processes that control the lineage fates
of hematopoietic stem and progenitor cells and how
lineage-committed progeny develop along particular maturation
pathways.
General
Imprint: |
nova science publishers
|
Country of origin: |
United States |
Release date: |
September 2010 |
Editors: |
Geoffrey Brown
|
Dimensions: |
180 x 260 x 24mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
342 |
ISBN-13: |
978-1-60741-733-0 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Haematology
|
LSN: |
1-60741-733-2 |
Barcode: |
9781607417330 |
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