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Books > Medicine > General issues > Medical equipment & techniques > Medical research
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Planning and Analyzing Clinical Trials with Composite Endpoints (Hardcover, 1st ed. 2017)
Loot Price: R3,716
Discovery Miles 37 160
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Planning and Analyzing Clinical Trials with Composite Endpoints (Hardcover, 1st ed. 2017)
Series: Springer Series in Pharmaceutical Statistics
Expected to ship within 12 - 17 working days
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This book addresses the most important aspects of how to plan and
evaluate clinical trials with a composite primary endpoint to
guarantee a clinically meaningful and valid interpretation of the
results. Composite endpoints are often used as primary efficacy
variables for clinical trials, particularly in the fields of
oncology and cardiology. These endpoints combine several variables
of interest within a single composite measure, and as a result, all
variables that are of major clinical relevance can be considered in
the primary analysis without the need to adjust for multiplicity.
Moreover, composite endpoints are intended to increase the size of
the expected effects thus making clinical trials more powerful. The
book offers practical advice for statisticians and medical experts
involved in the planning and analysis of clinical trials. For
readers who are mainly interested in the application of the
methods, all the approaches are illustrated with real-world
clinical trial examples, and the software codes required for fast
and easy implementation are provided. The book also discusses all
the methods in the context of relevant guidelines related to the
topic. To benefit most from the book, readers should be familiar
with the principles of clinical trials and basic statistical
methods.
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