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Planning and Analyzing Clinical Trials with Composite Endpoints (Hardcover, 1st ed. 2017) Loot Price: R4,126
Discovery Miles 41 260
Planning and Analyzing Clinical Trials with Composite Endpoints (Hardcover, 1st ed. 2017): Geraldine Rauch, Svenja Schuler,...

Planning and Analyzing Clinical Trials with Composite Endpoints (Hardcover, 1st ed. 2017)

Geraldine Rauch, Svenja Schuler, Meinhard Kieser

Series: Springer Series in Pharmaceutical Statistics

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Loot Price R4,126 Discovery Miles 41 260 | Repayment Terms: R387 pm x 12*

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This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful. The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from the book, readers should be familiar with the principles of clinical trials and basic statistical methods.

General

Imprint: Springer International Publishing AG
Country of origin: Switzerland
Series: Springer Series in Pharmaceutical Statistics
Release date: May 2018
First published: 2017
Authors: Geraldine Rauch • Svenja Schuler • Meinhard Kieser
Dimensions: 235 x 155mm (L x W)
Format: Hardcover
Pages: 255
Edition: 1st ed. 2017
ISBN-13: 978-3-319-73769-0
Categories: Books > Medicine > General issues > Medical equipment & techniques > Medical research
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LSN: 3-319-73769-4
Barcode: 9783319737690

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