This book is about pleasure. It's also about pain. Most important, it's about how to find the delicate balance between the two, and why now more than ever finding balance is essential.

We're living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting... The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we've all become vulnerable to compulsive overconsumption.

In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain...and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.

Consumption was the deadliest, most common disease that mankind has faced up till now. Three billion people in Europe and North America died between the fourteenth and the end of the eighteenth century. It was a death sentence with no known cause which led to the development of unusual empirical therapies. Lucky Consumptive patients reached a Sanatorium. Sanatoria were developed to house sick patients in an environment where they stood the best chance of recovery from their illness. There was no organised healthcare system and funding for a Sanatorium depended upon provision provided by wealthy individuals, or societies. Charles Dunnell Rudd was a Cape Merchant who had made a fortune in South Africa successfully prospecting for Gold and Diamonds. His mother had died from Consumption and he wished to invest some of his money in building a Sanatorium. It had been shown that Consumptive patients survived longer if they took vigorous exercise, slept out of doors, and were nursed on higher land near to forests. Rudd anonymously purchased raised land at Northwood for this purpose. Helena (later Princess Christian) was Queen Victoria's third daughter, and had a marked social awareness, arranging charitable meals for the less fortunate. She was very hard working and became the Principal Patron for Mount Vernon Hospital, donating money and attending annual fundraising Festival Dinners. Contemporary photographs from this period show female patients walking around the grounds and occupying designated rest shelters. The male patients had a more vigorous lifestyle, working in the gardens and sleeping in their beds out of doors. Those surviving often acquired new skills which might enhance their future employment prospects. These measures greatly improved the prognosis for consumptive patients. After Koch discovered the Tubercle Bacillus effective curative anti-tuberculous therapy evolved.

The definitive story of COVID-19 and how global politics shape our health - from a world-leading expert and the pandemic's go-to science communicator

Professor Devi Sridhar has risen to prominence for her vital roles in communicating science to the public and speaking truth to power. In Preventable she highlights lessons learned from outbreaks past and present in a narrative that traces the COVID-19 pandemic - including her personal experience as a scientist - and sets out a vision for how we can better protect ourselves from the inevitable health crises to come.

In gripping and heartfelt prose, Sridhar exposes the varied realities of those affected and puts you in the room with key decision makers at crucial moments. She vibrantly conveys the twists and turns of a plot that saw: deadlier varients emerge (contrary to the predictions of social media pundits who argued it would mutate to a milder form); countries with weak health systems like Senegal and Vietnam fare better than countries like the US and UK (which were consistently ranked as the most prepared); and the quickest development of game-changing vaccines in history (and their unfair distribution)

Combining science, politics, ethics and economics, this definitive book dissects the global structures that determine our fate, and reveals the deep-seated economic and social inequalities at their heart - it will challenge, outrage and inspire.

In this publication, description of the basic histology tissues is followed by a description of the histology of the different organs and systems in the human. The subject contents is presented on a relevant clinical level, and students in both medicine and dentistry, as well as related health professions, such as nursing, occupational therapy and physiotherapy, will find it simple and meaningful. The terminology used in the publication correlates with the writing style used as standard in English medical, dental and health care science' schools.

Required reading in many medical and healthcare institutions, How to Read a Paper is a clear and wide-ranging introduction to evidence-based medicine and healthcare, helping readers to understand its central principles, critically evaluate published data, and implement the results in practical settings. Author Trisha Greenhalgh guides readers through each fundamental step of inquiry, from searching the literature to assessing methodological quality and appraising statistics. How to Read a Paper addresses the common criticisms of evidence-based healthcare, dispelling many of its myths and misconceptions, while providing a pragmatic framework for testing the validity of healthcare literature. Now in its sixth edition, this informative text includes new and expanded discussions of study bias, political interference in published reports, medical statistics, big data and more. Offers user-friendly guidance on evidence-based healthcare that is applicable to both experienced and novice readers Authored by an internationally recognised practitioner and researcher in evidence-based healthcare and primary care Includes updated references, additional figures, improved checklists and more How to Read a Paper is an ideal resource for healthcare students, practitioners and anyone seeking an accessible introduction to evidence-based healthcare.

This book provides detailed and updated knowledge about medically important 'Big Four' venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell's viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing 'Big Four' venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of 'Big Four' venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms.

This book is about the theory of Hot and Cold, a mutual fundamental base of traditional medicines all around the world. The theory describes the dynamic balance state of the body on the axis of hot and cold for each individual and proposes the fact that deviation from this equilibrium is a predisposing factor for diseases. Such an approach helps practitioners to provide treatments tailored to the patient's condition, not the disease. This book, for the first time, has gathered native descriptions of Hot and Cold theory in different traditional medicines, including traditional Chinese medicine, Persian (Humoral, Unani) medicine, Ayurvedic medicine and Latin American and Caribbean medicines. After defining the common ground, contemporary research - in nutrition, pharmacology, physiology and systems biology - has been explored using scientific methodology. This work is the result of an international collaboration of more than 30 scientists and scholars with high reputations in their fields. Hot and Cold theory, as a holistic individualized approach in prevention, diagnosis and treatment, can be merged into the novel fast-paced concepts in systems biology and precision medicine. Through this bridge, the authors propose that the Hot and Cold theory should be revisited more deeply by medical scientists, who are the main audience of this book, to pave the way towards integrated holistic personalized medicine.

Research Methods in the Health Sciences provides clinical and non-clinical health science students with a comprehensive review of the designs and methods most frequently used in the discipline. Rather than preparing them to conduct original research, this text helps students develop a broad working knowledge of research processes across methodologies. Over the course of 10 chapters, students gain a strong understanding of the scientific method, evidence-based practice, deductive and inductive reasoning, ethical issues when conducting research, and the role of literature in the research process. They read about developing research problem statements and purpose statements, and asking sound research questions. Dedicated chapters illuminate how to select the right methodologies to ensure a study is valid, reliable, and trustworthy, how to understand qualitative and quantitative studies, and how to understand mixed methods research. Each chapter features field-tested tips for studying the material according to individual learning styles, as well as activities to help students develop high-order thinking skills. Written to help students develop foundational knowledge in the discipline, Research Methods in Health Sciences is an ideal resource for introductory courses in health science research methods.

The world's most widely used nursing research textbook, Essentials of Nursing Research, Tenth Edition equips students with everything they need to confidently apply research to nursing practice. AJN award-winning authors Denise Polit and Cheryl Beck clarify the language of nursing research and instill a practical understanding of nursing research fundamentals and the research process for both quantitative and qualitative studies - including design principles; sampling and data collection; criteria for assessing data quality; appraising the quality, rigor, and trustworthiness of studies; and approaches to understand the statistical results. This updated edition incorporates the latest clinical insights and approaches to research to familiarize students with increasingly important considerations in today's nursing practice, including the involvement of patients and stakeholders in translating research evidence to local settings; the appraisal of not only the rigor of research designs and methods but also the relevance and applicability of practice-based evidence; and the effective use of research in local quality improvement (QI) projects. UPDATED! Research insights reflect the latest, most relevant considerations for today's evolving nursing practice, including new coverage of quality improvement (QI) projects, clinical significance, comparative effectiveness research (CER), and systematic reviews. UPDATED! New organization simplifies the presentation of complex topics and better facilitates the use of research evidence in nursing practice. Clear, approachable writing makes difficult ideas easily digestible, even to students with no prior knowledge of technical terms. Critical Appraisal Guidelines walk students through studies and highlight aspects amenable to evaluation by research consumers. Research Examples and Critical Thinking Exercises emphasize important points and sharpen students' critical thinking skills. Tips help students confidently translate abstract notions of research methods into concrete applications. Colorful tables, figures, and examples engage students' attention and reinforce their understanding. Chapter Objectives emphasize essential information in each chapter. Key Terms familiarize students with common research terms. Bulleted Summary Points highlight key takeaways at a glance. Ensure a mastery of essential nursing skills and equip students for success throughout the nursing education continuum with the complete Essentials of Nursing Research, Tenth Edition solution: Lippincott (R) CoursePoint Study Guide for Essentials of Nursing Research, Tenth Edition

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

This book draws a unique perspective on the regulation of access to clinical trial data as a case on research and knowledge externalities. Notwithstanding numerous potential benefits for medical research and public health, many jurisdictions have struggled to ensure access to clinical trial data, even at the level of the trial results. Pro-access policy initiatives have been strongly opposed by research-based drug companies arguing that mandatory data disclosure impedes their innovation incentives. Conventionally, access to test data has been approached from the perspective of transparency and research ethics. The book offers a complementary view and considers access to individual patient-level trial data for exploratory analysis as a matter of research and innovation policy. Such approach appears to be especially relevant in the data-driven economy where digital data constitutes a valuable economic resource. The study seeks to define how the rules of access to clinical trial data should be designed to reconcile the policy objectives of leveraging the research potential of data through secondary analysis, on the one hand, and protecting economic incentives of research-based drug companies, on the other hand. Overall, it is argued that the mainstream innovation-based justification for exclusive control over the outcomes of research and development can hardly rationalise trial sponsors' control over primary data from trials. Instead, access to such data and its robust analysis should be prioritised.

This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.

The book Heat Shock Proteins in Cancer Therapeutics provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics. The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer selection offer promising solutions to overcome these challenges. Future advancements in this fast-growing area can potentially lead to the next generation of cancer therapeutics. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.