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This book provides a user-friendly introduction to the qualitative methods most commonly used in the mental health and psychotherapy arena. * Chapters are written by leading researchers and the editors are experienced qualitative researchers, clinical trainers, and mental health practitioners * Provides chapter-by-chapter guidance on conducting a qualitative study from across a range of approaches * Offers guidance on how to review and appraise existing qualitative literature, how to choose the most appropriate method, and how to consider ethical issues * Demonstrates how specific methods have been applied to questions in mental health research * Uses examples drawn from recent research, including research with service users, in mental health practice and in psychotherapy
New discoveries in the field of stem cells increasingly dominate
the news and scientific literature revealing an avalanche of new
knowledge and research tools that are producing therapies for
cancer, heart disease, diabetes, and a wide variety of other
diseases that afflict humanity. The Handbook of Stem Cells
integrates this exciting area of life science, combining in two
volumes the requisites for a general understanding of adult and
embryonic stem cells. Organized in two volumes entitled Pluripotent
Stem Cells & Cell Biology and Adult & Fetal Stem Cells,
this work contains contributions from the world s experts in stem
cell research to provide a description of the tools, methods, and
experimental protocols needed to study and characterize stem cells
and progenitor populations as well as a the latest information of
what is known about each specific organ system.
Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.
Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
This book integrates philosophy of science, data acquisition methods, and statistical modeling techniques to present readers with a forward-thinking perspective on clinical science. It reviews modern research practices in clinical psychology that support the goals of psychological science, study designs that promote good research, and quantitative methods that can test specific scientific questions. It covers new themes in research including intensive longitudinal designs, neurobiology, developmental psychopathology, and advanced computational methods such as machine learning. Core chapters examine significant statistical topics, for example missing data, causality, meta-analysis, latent variable analysis, and dyadic data analysis. A balanced overview of observational and experimental designs is also supplied, including preclinical research and intervention science. This is a foundational resource that supports the methodological training of the current and future generations of clinical psychological scientists.
This brief highlights recent research advances in the area of nano-therapeutics. Nanotechnology holds immense potential for application in a wide range of biological and engineering applications such as molecular sensors for disease diagnosis, therapeutic agents for the treatment of diseases, a vehicle for delivering therapeutics and imaging agents for theranostic applications, both in-vitro and in-vivo. The brief is grouped into the following sections namely, A) Discrete Nanosystems ; B) Anisotropic Nanoparticles; C) Nano-films/coated/layered and D) Nano-composites.
Searching Skills Toolkit is an expert guide to help you find the clinical evidence you need more easily and effectively. Clearly presented with useful tips and advice, flow charts, diagrams and real-life clinical scenarios, it shows the best methods for finding quality evidence. From deciding where to start, to building a search strategy, refining results and critical appraisal, it is a step-by-step guide to the process of finding healthcare evidence, and is designed for use by all health and social care professionals. This second edition has been expanded with new chapters on searching for sources to support evidence-based management decision making and how to better enable your patients to make informed choices. It has also been fully updated to include new web sources, open source reference management software, and new training resources and exercises. Searching Skills Toolkit is an ideal reference for doctors, nurses, allied health professionals, managers and decision makers, researchers and students.
Paxinos and Ashwell's Atlas of the Developing Rat Nervous System, Fourth Edition, builds on the many excellent features of previous editions that have made this book the most cited atlas of the developing rat brain. It provides the most comprehensive depiction of not only the structures in the brain and spinal cord, but also of the peripheral nervous system and target organs that are important for developmental neurobiologists, allowing the user to follow neural structures through the developing embryo in both time and space. The nomenclature and identification of structures in this edition have been thoroughly updated to ensure accuracy and compatibility.
Tony Seed, Gilbert Thompson, Jackie Downs and John MacDermot at the book's launch in LondonThis book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research.Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation's website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise.
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
New Developments in Dementia Prevention Research addresses a dearth of knowledge about dementia prevention and shows the importance of considering the broader social impact of certain risk factors, including the role we each play in our own cognitive health throughout the lifespan. The book draws on primary and secondary research in order to investigate the relationship between modifiable factors, including vascular and psychosocial risks, that may affect the incidence of dementia. Bringing together world-leading expertise from applied science, medicine, psychology, health promotion, epidemiology, health economics, social policy and primary care, the book compares and contrasts scientific and service developments across a range of settings. Each chapter presents these themes in a way that will ensure best practice and further research in the field of dementia prevention is disseminated successfully throughout the world. Perhaps most importantly, chapters also question what type of social responsibility we are prepared to embrace in order to address the challenges inherent in dementia prevalence. New Developments in Dementia Prevention Research includes contributions from leading authorities in brain health and dementia prevention and provides an essential contribution to the discourse on dementia prevention. It will be of great interest to academics, researchers and postgraduate students engaged in the study of the psychological and social aspects of aging and dementia.
At last - a new edition of the highly claimed book "Clinical Trials in Psychiatry"
This book provides a concise but thorough overview of clinical trials in psychiatry, invaluable to those seeking solutions to numerous problems relating to design, methodology and analysis of such trials. Practical examples and applications are used to ground theory whenever possible. The Second Edition includes new information regarding: Recent important psychiatric trials More specific discussion of psychiatry in the USA and the particular problems of trials in the USA, including comments about the FDA (U.S. Food and Drug Administration) An extended chapter on meta-analysis Further discussion of sub-group analysis
Special features include appendices outlining how to design and report clinical trials, what websites and software programs are appropriate and an extensive reference section.
From the reviews of the First Edition:
""Everitt & Wessely are to be congratulated on producing an excellent guide to help overcome the snags in clinical trial research. Clearly written and in an engrossing style, the book is likely to become a classic textbook on clinical trials, and not just in psychiatry. The authors' enthusiasm and grasp of clinical trial research make for a gripping and insightful read...it is one of the very best books that has been written on clinical trials."" THE BRITISH JOURNAL OF PSYCHIATRY
""The experience of both authors in this area gives the book a very pragmatic approach grounded in reality, with theoretical overviews invariably being followed by practical examples and applications... an invaluable companion to anyone involved in, or contemplating undertaking, clinicaltrials research."" PSYCHOLOGICAL MEDICINE
This book is a continuation of the book Medicine Researcher Biographical Sketches and Research Summaries which compiles biographical sketches of top professionals in the field of medicinal research, as well as research summaries from a number of different focuses in this important field.
This updated final volume in the best-selling series of reference works features descriptions of more than 200 genera in 49 families and includes a revised taxonomic outline for the Actinobacteria as well as many medically and industrially important taxa.
Helps researchers in proteomics and oncology work together to understand, prevent, and cure cancer
Proteomic data is increasingly important to understanding the origin and progression of cancer; however, most oncologic researchers who depend on proteomics for their studies do not collect the data themselves. As a result, there is a knowledge gap between scientists, who devise proteomic techniques and collect the data, and the oncologic researchers, who are expected to interpret and apply proteomic data. Bridging the gap between proteomics and oncology research, this book explains how proteomic technology can be used to address some of the most important questions in cancer research.
"Proteomic Applications in Cancer Detection and Discovery "enables readers to understand how proteomic data is acquired and analyzed and how it is interpreted. Author Timothy Veenstra has filled the book with examples--many based on his own firsthand research experience--that clearly demonstrate the application of proteomic technology in oncology research, including the discovery of novel biomarkers for different types of cancers.
The book begins with a brief introduction to systems biology, explaining why cancer is a systems biology disease. Next, it covers such topics as: Mass spectrometry in cancer researchApplication of proteomics to global phosphorylation analysisSearch for biomarkers in biofluidsRise and fall of proteomic patterns for cancer diagnosticsEmergence of protein arraysRole of proteomics in personalized medicine
The final chapter is dedicated to the future prospects of proteomics in cancer research.
By guiding readers through the latest proteomic technologies and their applications in cancer research, "Proteomic Applications in Cancer Detection and Discovery" enhances the ability of researchers in proteomics and researchers in oncology to collaborate in order to better understand cancer and develop strategies to prevent and treat it.
This book represents an actual view on the current trends in the area of respiratory therapy research. The amount of new information in each field of clinical medicine is astonishing and therefore we considered it very important to catch this exciting movement in the form of monograph dedicated to the advances in therapy research of various respiratory diseases. The chapters analyse the therapeutic strategies and perspectives in the management of the most common chronic diseases, especially in childhood. Due to very rapid progress in this area, it is very important that the authors succeed in summarising the most knowledge and data about the available and possible future therapies of bronchial asthma, primary ciliary dyskinesia, chronic and acute cough, and obstructive sleep apnea syndrome. Aside from clinical chapters, the readers can also find experimental studies analysing the possible therapeutic application of different medications and chest physiotherapy. A very important part of each chapter is the current view on the pathogenesis of particular diseases, in which understanding is crucial for better, targeted therapy and research of novel therapeutic modalities. We hope that this book will find its readers and will help physicians and other interested people to understand the most recent trends in the treatment and management of respiratory diseases.
This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics. Individual sections offer in-depth coverage of various topics relating to glycans and biopharmaceuticals, glycans in medical science and medicine, glycan technologies, glycans in food and nutrients, and glycan-related materials and their uses. In addition, the book presents an exemplary training course on glycomics and highlights educational and analytical web resources, and also includes glossaries and boxes summarizing key facts to ensure ease of understanding for non-expert readers and students. Written by more than 150 active participants in the Japan Consortium for Glycobiology and Glycotechnology (JCGG), whose goal is to promote the development of interdisciplinary glycoscience and establish a global network in the field, it is a valuable resource for students, postdocs, and researchers in the life sciences as well as for stakeholders and professionals in government, funding agencies and industry.
There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book's website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others
Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytes-or over 50 million gigabytes-of genomic data, and they're turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud? With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian O'Connor of the UC Santa Cruz Genomics Institute, guide you through the process. You'll learn by working with real data and genomics algorithms from the field. This book covers: Essential genomics and computing technology background Basic cloud computing operations Getting started with GATK, plus three major GATK Best Practices pipelines Automating analysis with scripted workflows using WDL and Cromwell Scaling up workflow execution in the cloud, including parallelization and cost optimization Interactive analysis in the cloud using Jupyter notebooks Secure collaboration and computational reproducibility using Terra
Understand how to implement high-quality evaluations within different cultural contexts in the world. Evaluation in Today's World: Respecting Diversity, Improving Quality, and Promoting Usability is a timely and comprehensive textbook that guides students, practitioners, and users of evaluations in understanding evaluation purposes, theories, methodologies, and challenges within today's sociocultural and political context. Veronica G. Thomas and Patricia B. Campbell include discussions of evaluation history, frameworks, models, types, planning, and methods, through a social justice, diversity, and inclusive lens. The authors focus on ethics in diverse cultural contexts, help readers understand how social problems and programs get politicized and, sometimes, framed through a racialized lens, show how to engage stakeholders in the evaluation process, and communicate results in culturally appropriate ways.
This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.
This book reviews the theory and practice of fractional flow reserve (FFR)-guided coronary intervention, a technique that gives sense and a rationale to daily decisions in the interventional suite. FFR guidance provides detailed information on coronary hemodynamics for the interventional cardiologist. This technique has profound practical implications for therapeutic decisions and for the prognosis of patients. The Atlas of FFR-Guided Percutaneous Coronary Interventions provides practicing physicians clear information to understand both the complexity of the technique and the correct way to apply it. It is designed both to assist younger faculty and those in training, and to act as a clinical resource for more experienced practitioners. Using the clinical cases outlined, the reader can learn to appreciate the pitfalls, tips and tricks that simplify the performance and interpretation of FFR and iFR.
Throughout history black seeds, Nigella sativa seeds, have been highly revered for its medicinal properties. Thymoquinone (TQ), an active principle component of the volatile oil of black cumin seeds, is an emerging natural compound with a wide range of medical applications, and has several beneficial pharmacological actions i.e anti-oxidant, anti-diabetic, anti-inflammatory, anti-microbial, anti-tumor, anti-mutagenic, anti-epileptic, hepatoprotective, neuroprotective, and nephroprotective. As such, it is important to move TQ from the bench to bedside. This book illustrates the therapeutic importance of TQ, offering a detailed account of some of its molecular and therapeutic properties, and discussing in depth its anti-diabetic, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial, anti-epileptic and hepatoprotective actions. Lastly, the book examines the future prospects of TQ research and its use as a pharmaceutical.
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.
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