Accelerated Path to Cures (Hardcover, 1st ed. 2018)

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Release date:	May 2018
First published:	2018
Editors:	Josep Bassaganya-Riera
Dimensions:	235 x 155 x 14mm (L x W x T)
Format:	Hardcover
Pages:	82
Edition:	1st ed. 2018
ISBN-13:	978-3-319-73237-4
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	3-319-73237-4
Barcode:	9783319732374

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