Cell fusions are important to fertilization, placentation,
development of skeletal muscle and bone, calcium homeostasis and
the immune defence system. Additionally, cell fusions participate
in tissue repair and may be important to cancer development and
progression. A large number of factors appear to regulate cell
fusions, including receptors and ligands, membrane domain
organizing proteins, proteases, signaling molecules and fusogenic
proteins forming alpha-helical bundles that bring membranes close
together. The purpose of the planned volume is to sum up current
knowledge about mechanisms regulating and controlling cell fusions.
The field has expanded vastly within the past few years and leaders
in the field will be invited to contribute with current overviews
of their specific areas of knowledge. Attention will be paid both
to true fusogens like proteins encoded by the viral (e.g. HIV),
caenorhabdidtis (EFF) mammalian and human (e.g. syncytins and Pb-1)
genomes as well as to mechanisms regulating the activities of the
fusogens. The commitment of cells to fuse represents an
irreversible step. It stands to reason that a number of factors
controlling and safe-guarding these mechanisms must exist. It seems
equally reasonable to assume that many of these mechanisms are
redundant in different systems. By bringing together experts
working in each their system there is a fair chance that a
consensus concerning the mechanistics of cell fusions may develop.
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