The field of stem cell biology is geared towards translation
into clinical practice through in vitro tissue production and
regeneration therapy. Since the discovery of adult neurogenesis,
much attention has been put on the study of differentiation of stem
cells into neural cell types and the development of model systems
for stroke and neurodegenerative diseases.
In addition to chapters on therapeutic applicability of
embryonic, very small-embryonic like, mesenchymal stem and neural
progenitor cells, this book covers signalling mechanisms guiding
induction to differentiation and cell diversification. Furthermore,
fundamental aspects of stem cell biology and neurogenesis, such as
the importance of proliferation induction, programmed cell death
and the function of glia in differentiation of stem cells and
development of neuronal circuits, are also highlighted. In vitro
cultures of embryonic, mesenchymal and neural stem cells as well as
mobilization of endogenous stem and precursor cells for brain
repair and replacement therapy in neurological disorders are
important issues of this book.
Each chapter is written by researchers who are leaders in the
field and provides an invaluable resource for information on the
most current advances in the field and possible therapeutic
applications, with discussions of controversial issues and areas of
emerging importance. By providing an up-to-date and critical view
of the state of Science, we hope that this book shall be a base for
exciting scientific ideas regarding functions and therapeutic
applications of stem cells in the adult brain. The book is directed
to neuroscientists, physicians, students and all who are engaged
and interested in the exciting and rapidly expanding field of
modern neuroscience and stem cell biology.
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