With the explosion of information on autophagy in cancer, this is
an opportune time to speed the efforts to translate our current
knowledge about autophagy regulation into better understanding of
its role in cancer. This book will cover the latest advances in
this area from the basics, such as the molecular machinery for
autophagy induction and regulation, up to the current areas of
interest such as modulation of autophagy and drug discovery for
cancer prevention and treatment. The text will include an
explanation on how autophagy can function in both oncogenesis and
tumor suppression and a description of its function in tumor
development and tumor suppression through its roles in cell
survival, cell death, cell growth as well as its influences on
inflammation, immunity, DNA damage, oxidative stress, tumor
microenvironment, etc. The remaining chapters will cover topics on
autophagy and cancer therapy. These pages will serve as a
description on how the pro-survival function of autophagy may help
cancer cells resist chemotherapy and radiation treatment as well as
how the pro-death functions of autophagy may enhance cell death in
response to cancer therapy, and how to target autophagy for cancer
prevention and therapy what to target and how to target it.
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