"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers AEG-1/MTDH/Lyric implicated in multiple human cancers.
Provides information on cancer researchOutstanding and original reviewsSuitable for researchers and students

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
Provides information on cancer researchOutstanding and original reviewsSuitable for researchers and students

Alternative medicine: Herbal drugs and their critical appraisal - Part II.- Virus population dynamics, fitness variations and the control of viral disease: an update.- Applications of yeast in drug discovery.- Sympathetic nervous system and experimental diabetes: role of adrenal medullary hormones.- From outer to inner space: Traveling along a scientific career from astrochemistry to drug research.- Index Vol. 57.- Index of titles, Vol. 1-57.- Author and paper index, Vol. 1-57.

Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium "Legionella pneumophila." This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to "L. pneumophila." Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen "L. pneumophila.""

Written to satisfy a wide audience, from basic scientist to clinical researcher, this volume explores such varied concepts as: the influence of CBF in the pathotrajectory of TBI, modeling TBI as a means to understand underlying pathological states associated with brain injury victims, disrupted vasculature following head trauma and advanced imaging techniques, vasoreactive substances underlying disrupted blood flow, the role of age and sex on injury outcome, and the latest pre-clinical rationale for focusing on CBF and strategies to improve blood flow as a means to improve outcome in patients suffering the effects of TBI.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging
Covers the area of Stem Cells in Development and DiseaseInternational board of authors Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells

The development of treatment strategies that can help patients with spinal cord injury to regain lost functions and an improved quality of life is a major medical challenge, and experimental spinal cord research has to meet these challenges by resolving fundamental problems, establishing a basis for possible novel treatment strategies of spinal cord injury, and motivating their clinical translation. In "Animal Models of Spinal Cord Repair," expert researchers examine a broad range of experimental models for research on spinal cord injury, how they have contributed to our current state of knowledge, and what their advantages are in the further advancement of spinal cord repair. With models from simple lamprey to non-human primates, the information presented is intended to guide the implementation of animal models for spinal cord repair as well as to raise the awareness of the relevance of experimental models which may not be in the current mainstream of this research. As a part of the "Neuromethods" series, this work contains the kind of detailed description and implementation advice to guarantee successful results in the laboratory.

Comprehensive and cutting-edge, "Animal Models of Spinal Cord Repair" presents the background information and hands-on methods descriptions, as well as the basic and clinical issues, needed to stimulate and guide researchers with different backgrounds towards the development of improved strategies for functionally relevant repair of the injured human spinal cord."

Today, when many parents seem reluctant to have their children vaccinated, even with long proven medications, the Salk vaccine trial, which enrolled millions of healthy children to test an unproven medical intervention, seems nothing short of astonishing. In Selling Science, medical historian Stephen E. Mawdsley recounts the untold story of the first large clinical trial to control polio using healthy children - 55,000 healthy children - revealing how this long-forgotten incident cleared the path for Salk's later trial. Mawdsley describes how, in the early 1950s, Dr. William Hammon and the National Foundation for Infantile Paralysis launched a pioneering medical experiment on a previously untried scale. Conducted on over 55,000 healthy children in Texas, Utah, Iowa, and Nebraska, this landmark study assessed the safety and effectiveness of a blood component, gamma globulin, to prevent paralytic polio. The value of the proposed experiment was questioned by many prominent health professionals as it harbored potential health risks, but as Mawdsley points out, compromise and coercion moved it forward. And though the trial returned dubious results, it was presented to the public as a triumph and used to justify a federally sanctioned mass immunization study on thousands of families between 1953 and 1954. Indeed, the concept, conduct, and outcome of the GG study were sold to health professionals, medical researchers, and the public at each stage. At a time when most Americans trusted scientists, their mutual encounter under the auspices of conquering disease was shaped by politics, marketing, and at times, deception. Drawing on oral history interviews, medical journals, newspapers, meeting minutes, and private institutional records, Selling Science sheds light on the ethics of scientific conduct, and on the power of marketing to shape public opinion about medical experimentation.

With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to each of the applications. It can be used by those both at graduate and specialist levels.

"Animal Models for the Study of Human Disease" identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. Thefirst section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.
Organized by disease orientation for ease of searchabilityProvides information on locating resources, animal alternatives and animal ethicsCovers a broad range of animal models used in research for human disease"

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents a practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and Toxicology(t) series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

This book contains the full papers presented at the MICCAI 2013 workshop Bio-Imaging and Visualization for Patient-Customized Simulations (MWBIVPCS 2013). MWBIVPCS 2013 brought together researchers representing several fields, such as Biomechanics, Engineering, Medicine, Mathematics, Physics and Statistic.

The contributions included in this book present and discuss new trends in those fields, using several methods and techniques, including the finite element method, similarity metrics, optimization processes, graphs, hidden Markov models, sensor calibration, fuzzy logic, data mining, cellular automation, active shape models, template matching and level sets. These serve as tools to address more efficiently different and timely applications involving signal and image acquisition, image processing and analysis, image segmentation, image registration and fusion, computer simulation, image based modelling, simulation and surgical planning, image guided robot assisted surgical and image based diagnosis.

This book will appeal to researchers, PhD students and graduate students with multidisciplinary interests related to the areas of medical imaging, image processing and analysis, computer vision, image segmentation, image registration and fusion, scientific data visualization and image based modeling and simulation.

Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. That, along with their low cost, easy manipulation, short reproductive cycles, and physiological homology to humans, has made zebrafish a vital model organism for neuroscience research. Zebrafish Protocols for Neurobehavioral Research addresses protocols for both larval and adult models, written by the leading experts in the field of zebrafish research. Part I of this book takes advantage of the high-throughput nature of larval models to offer protocols for research requiring high output, easily manipulated screens. The second half of the book focuses on the robust and sophisticated behaviors of adult zebrafish, suitable for the neurophenotyping of complex traits and multi-domain disorders. Importantly, these models complement each other, working together to provide researchers with valuable insights into neurobiology of normal and pathological behavior. Thorough and cutting-edge, this volume is a useful, authoritative reference guide that should hold a coveted spot in zebrafish laboratories across the globe.

Injury is recognized as a major public health issue worldwide. In most countries, injury is the leading cause of death and disability for children and young adults age 1 to 39 years. Each year in the United States, injury claims about 170,000 lives and results in over 30 million emergency room visits and 2.5 million hospitalizations. Injury is medically defined as organ/tissue damages inflicted upon oneself or by an external agent either accidentally or deliberately. Injury encompasses the undesirable consequences of a wide array of events, such as motor vehicle crashes, poisoning, burns, falls, and drowning, medical error, adverse effects of drugs, suicide and homicide. The past two decades have witnessed a remarkable growth in injury research, both in scope and in depth. To address the tremendous health burden of injury morbidity and mortality at the global level, the World Health Organization in 2000 created the Department of Injury and Violence Prevention, which has produced several influential reports on violence, traffic injury, and childhood injury. The biennial World Conference on Injury Control and Safety Promotion attracts a large international audience and has been successfully convened nine times in different countries. In the United States, the National Center for Injury Prevention and Control became an independent program of the federal Centers for Disease Prevention and Control in 1997. Since then, each state health department has created an office in charge of injury prevention activities and over a dozen universities have established injury control research centers. This volume will fill an important gap in the scientific literature by providing a comprehensive and up-to-date reference resource to researchers, practitioners, and students working on different aspects of the injury problem and in different practice settings and academic fields.

Published since 1953, "Advances in Virus Research" covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.
Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors. Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing's sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail. The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation. Discussion includes diagnosis and treatment of other pediatric tumors including adrenocortical tumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma. Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.

This volume of "Progress in Molecular Biology and Translational Science" discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

The Badgastein Lecture.- The Challenge of the 21st Century.- Neurology, Psychiatry.- First Evaluation in Humans of [123I]PE21: A Selective Radioligand for Visualization of the Striatal Dopamine Transporter Density.- Comparison of Iodine-123 labelled Nor-ss-Cit and ss-Cit as Potential Radioligands for Serotonin Transporter Imaging.- Brain Serotonin and Dopamine Transporters in Depressive Children.- Prognostic Potential of Tc-99m-ECD-SPET within 6 Hours after Onset of Stroke Symptoms.- Brain Perfusion in Patients with Severe Sleep Apnea Syndrome (SAS) before and after n-CPAP-Therapy.- Therapy.- Radioimmunotherapy of Colorectal Cancer in Small Volume Disease: Preclinical Evaluation in Comparison To Equitoxic Chemotherapy and Preliminary Results of an Ongoing Phase-I/II Clinical Trial.- Radioimmunotherapy of Glioblastoma by Using I-131 and Y-90 Labeled Anti-tenascin Monoclonal Antibodies.- I-131-Lipiodol Therapy in Liver Neoplasms.- Individualized Dose Estimation for Sr-89 with the Use of Diagnostic Tc-99m MDP Bone Scintigraphy.- Rhenium-186-HEDP and Strontium-89-Chloride in Treatment of Metastatic Bone Pain.- The Development of Chromatographic 188W/188Re Generators for Therapy.- Radiopharmacology.- Evaluation of mRNA Targeting by Labeled Oligonucleotides for Tumor-Diagnosis.- Synthesis and Evaluation of [123I]-Iodoaminoglutethimide, a Ligand for Visualization of the Aromatase Enzyme by SPECT.- Comparative Analysis of Kinetic Models to Study Glucose Metabolism of the Brain.- Bone Scintigraphy and Palliative Therapy with Multibone Kit.- Pharmaosintigraphic Study of Localization in the G.I. Tract of Controlled Release Tablets Using 153Sm as Marker.- Endocrinology, Thyroid.- On the Use of Routine Preoperative Scintigraphy in Thyroid Carcinoma Patients.- The Value of HMPAO SPECT Scanning in Patients with Congenital Hypothyreosis.- Advanced Stage Thyroid Cancer - Treatment with Isotretinoin.- Is SPECT-Technique Necessary for Preoperative Diagnosis of Parathyroid Adenoma ?.- Oncology, Haematology.- Comparison of Interlesionally and Systemically Administered Radiolabelled Monoclonal Antibodies in Implanted Tumours.- Comparison of MRI and Somatostatin Receptor Scintigraphy (SRS) in Post-surgical Follow-up of Meningioma.- Comparison of Contrast Enhanced MRI, Tc-99m Hydroxymethylene Diphosphonate and Tc-99m Tetrofosmin Scintimammography in Patients with Suspicious Breast Lesions.- Neoadjuvant Treatment of Patients with Breast Cancer under Surveillance of 99mTc-Tetrofosmin Scintigraphy.- 99Tc-Furifosmin Uptake by Melanoma Cells.- Lymphoscintigraphy in Tumors of the Head and Neck Using a Double Tracer Technique.- Clinical PET.- Clinical Application of 18FDG-PET in the Assessment of Head and Neck Tumors.- The Role of FDG-PET and MIBI Investigations in the Restaging of Treated Patients with Malignant Lymphomas.- Assessment of Pulmonary Nodules and Colorectal Cancer Recurrences by FDG Scan on an"Ordinary" Coincidence Gamma Camera (CDET).- Clinical Utility of 18FDG-PET with Molecular Coincidence Detection (MCD) and a Modified SPECT-Camera.- Deoxyglucose Uptake by Apoptosing and Proliferating Colonic Tumour Cells.- Cardiology.- Relation Between Viability, Improvement of LVEF and Heart Failure Symptoms after Revascularization.- Attenuation Corrected Tl-201 SPECT Using a Gd-153 Moving Line Source: Clinical Value and the Impact of Attenuation Correction on the Extent and Severity of Perfusion Abnormalities.- Correlation of EBCT and Tl-201-SPECT Scintigraphy in Patients with Coronary Heart Disease.- Influence of Right Ventricular Stimulation Site on Left Ventricular Function in a Trial Synchronous Pacing.- Varia.- 153Sm-EDTMP for Pain Relief in Malignant and Benign Bone and Joint Diseases.- Tc-99m-Tetrofosmin SPECT Scintigraphy in the Post-operative Follow-up of Microvascular Anastomosed Flaps in Facial Reconstruction.- Long-Term Follow-up Study of Gastric Emptying and Helicobacter Pylori Eradication among Patients with Functional Dyspepsia.- The Valu

This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer's Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.

As the first primer on the effects of exercise on human hypertension, Effects of Exercise on Hypertension: From Cells to Physiological Systems provides the state-of-the-art effects of exercise on the many possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as 24-hour ambulatory blood pressure profile and oxidative stress. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. Lastly, the book will end with a chapter on the interactive effects of genes and exercise on blood pressure. Chapters are grouped by physiological system or mechanism. The text begins with two overview chapters; one on the general effects of aerobic exercise training and the second on the general effects of resistance exercise training on blood pressure. Each chapter begins with a bulleted list of key points. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.

Plants and other living organisms have great potential to treat human disease. There are two distinct types of biomedical research that seek to develop this potential. One type of research explores the value of medicinal plants as traditionally used andstudies of these plants have the potential to determine which plants are most potent, optimize dosages and dose forms, and identify safety risks. Another type of research uses bioassays to identify single molecules from plants that have interesting bioactivities in isolation and might be useful lead compounds for the development of pharmaceutical drugs.

This new volume of Advances in Botanical Research covers the recent trends in Medicinal Plants Research over 11 chapters. Topics that are covered include Development of Drugs from Plants - Regulation and Evaluation, Chinese Herbal Medicines for Rheumatoid Arthritis, and Taxol, camptothecin and beyond for cancer therapy.
Covers the recent trends in medicinal plants research over 11 chaptersTopics that are covered include Development of Drugs from Plants - Regulation and Evaluation, Chinese Herbal Medicines for Rheumatoid Arthritis, and Taxol, camptothecin and beyond for cancer therapy"