|
Books > Science & Mathematics > Biology, life sciences > Molecular biology
|
Buy Now
Retinoids: Their Physiological Function and Therapeutic Potential, Volume 3 (Hardcover)
Loot Price: R2,920
Discovery Miles 29 200
|
|
|
Retinoids: Their Physiological Function and Therapeutic Potential, Volume 3 (Hardcover)
Series: Advances in Organ Biology
Expected to ship within 12 - 19 working days
|
Retinoids have received considerable attention in recent years and
due cognizance has been given to their versatility as biological
response modifiers, as evidenced by the virtually explosive growth
of literature in this field in the past few years. This volume has
been designed to give a current state-of-the-art picture of
retinoids. The perceived potential of retinoids in the treatment of
certain disease stated has initiated attempts at identifying and
synthesizing new retinoid derivatives with definable and selective
effects on aberrant biological phenomena. Appropriately, therefore,
we begin with the chemistry of retinoids and their derivatives
together with discussions of their biological activity. Major
advances have been made in understanding the mechanisms by which
retinoids modulate physiological and phenotypic traits of cells.
The transduction of retinoid signaling by the mediation of nuclear
receptors of the steroid/thyroid receptor superfamily has now been
studied extensively and the cloning and defining the
characteristics of these receptors has been a focus of discussion
in this volume. Retinoids also markedly modulate the transduction
of extracellular signals such as those imparted by growth factors
and hormones, and thus actively influence and control cellular
proliferative patterns. Retinoids can alter epidermal growth factor
receptor expression (Kawaguchi et al., 1994), responsiveness to
thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994),
inhibit the proliferative responses of hematopoietic progenitor
cells to granulocyte colony stimulating factor (Smeland et al.,
1994), and modulate secretion on interleukins by leukaemic cells
(Balitrand et al., 1994), among other things. This has obvious
implications for pharmacological manipulation of deregulated growth
(Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is
another component in the regulation of growth control. Apoptotic
cell death is influenced by several agents and retinoids may
function by interfering with apoptotic pathways of regulation of
growth control and quite legitimately, therefore, the importance of
this aspect of retinoid function has been duly recognized here.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
You might also like..
|
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
