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Books > Medicine > General issues > Medical equipment & techniques > Medical research

Regenerative Medicine - from Protocol to Patient - 2. Stem Cell Science and Technology (Hardcover, 3rd ed. 2016): Gustav... Regenerative Medicine - from Protocol to Patient - 2. Stem Cell Science and Technology (Hardcover, 3rd ed. 2016)
Gustav Steinhoff
R4,734 R4,014 Discovery Miles 40 140 Save R720 (15%) Ships in 12 - 17 working days

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 2 contains sixteen chapters addressing advanced knowledge on "Stem Cell Science and Technology" addressing basic classification technology, cell biology of stemness state and regulatory molecular pathways. Mechanisms and technology of cell programming are explained, as well as the pathology of cancer cells and dedifferentiation signalling. Pluripotent, multipotent germline and tissue specific human stem cells are classified and qualified according to their respective biological function or tissue regeneration. Leading stem cell scientists from all over the world explain advanced technology, latest knowledge, and clinical implications of human stem cell science in a unique, comprehensive and detailed outline.

Regenerative Medicine - from Protocol to Patient - 3. Tissue Engineering, Biomaterials and Nanotechnology (Hardcover, 3rd ed.... Regenerative Medicine - from Protocol to Patient - 3. Tissue Engineering, Biomaterials and Nanotechnology (Hardcover, 3rd ed. 2016)
Gustav Steinhoff
R4,174 R3,659 Discovery Miles 36 590 Save R515 (12%) Ships in 12 - 17 working days

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes, Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. The collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 3: Tissue engineering, Biomaterials and Nanotechnology focuses the development of technologies, which enable an efficient transfer of therapeutic genes and drugs exclusively to target cells and potential bioactive materials for clinical use. Principles of tissue engineering, vector technology, multifunctionalized nanoparticles, biodegradable materials, controlled release, and biointerface technology are described with regard to the development of new clinical cell technology. Imaging and targeting technologies as well as biological aspects of tissue and organ engineering are depicted.

Evaluating Research - Methodology for People Who Need to Read Research (Paperback, 3rd Revised edition): Francis C. Dane,... Evaluating Research - Methodology for People Who Need to Read Research (Paperback, 3rd Revised edition)
Francis C. Dane, Elliot Donald Carhart
R2,018 Discovery Miles 20 180 Ships in 12 - 17 working days

The third edition of Evaluating Research by Francis C. Dane and Elliot Carhart provides students with the skills to read and evaluate research studies. Aimed at courses where it is more important for students to develop an understanding of methods, rather than conduct their own research, this book covers all aspects of reading social, behavioral, and health science research from the basics, such as the structure of reports and accessing research, as well as overviews of the main types of research methods. The authors emphasize critical reading skills to enable students to become experts in evaluating research, so students can decide whether to incorporate that research into their future professional activities. Each chapter includes an overview at the beginning and exercises at the end to reinforce the content learned. Starting from the basic principles of why we do research, the book moves readers through the practicalities of finding studies to the principles of the scientific method and how to break down and analyze research reports. New to the third edition, Understanding Checks placed throughout each chapter help students cement their learning. The organization of the book is now more logical, with a new chapter on accessing research up front and ending with a chapter on statistical analyses. New research examples throughout, including such topical examples as mindfulness, college attendance, and bias in healthcare, help students see the relevance of research in their lives.

Tamoxifen Tales - Suggestions for Scientific Survival (Hardcover): V.Craig Jordan Tamoxifen Tales - Suggestions for Scientific Survival (Hardcover)
V.Craig Jordan
R2,142 Discovery Miles 21 420 Ships in 12 - 17 working days

Tamoxifen Tales: Suggestions for Scientific Survival presents a case study describing the academic journey of teams behind major advances in medical sciences, highlighting lessons learned that are applicable to the next generation of scientists. This book provides a manual on the successful mentoring of young scientists, including stories describing how training experience shaped careers to become leaders in academia and the pharmaceutical industry. The book documents Professor V. Craig Jordan's 50-year career in medical sciences that led to the discovery and development of Selective Estrogen Receptor Modulators (SERMs), which became the standard of women's healthcare around the world. Additionally, it illustrates the versatility of a scientist with a commitment to serving societies. This important resource will be a useful and interesting book for established medical scientists, research mentors and advanced students wanting to chart a successful and impactful research career.

Sample Sizes for Clinical Trials (Hardcover, 2nd edition): Steven A. Julious Sample Sizes for Clinical Trials (Hardcover, 2nd edition)
Steven A. Julious
R2,740 Discovery Miles 27 400 Ships in 9 - 15 working days

Sample Sizes for Clinical Trials, Second Edition is a practical book that assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them to colleagues or in protocols. The book also highlights some of the pitfalls in calculations as well as the key steps that lead to the final sample size calculation. Features: Comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data Covers superiority, equivalence, non-inferiority, bioequivalence and precision objectives for both parallel group and crossover designs Highlights how trial objectives impact the study design with respect to both the derivation of sample formulae and the size of the study Motivated with examples of real-life clinical trials showing how the calculations can be applied New edition is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single arm trials The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.

Which Treatment Is Best? Spoof or Proof? (Paperback): Teddy Bader Which Treatment Is Best? Spoof or Proof? (Paperback)
Teddy Bader
R743 Discovery Miles 7 430 Ships in 9 - 15 working days

Key Features: 1. Describes the development of the randomized, controlled trial as the gold standard of proof. 2. Unravels the meaning of "randomized," "double-blind" and "p-values" in a simplified manner for students and clinicians. 3. Contains timeless information on how medical evidence can be understood.

Understanding Clinical Papers 4e (Paperback, 4th Edition): D. Bowers Understanding Clinical Papers 4e (Paperback, 4th Edition)
D. Bowers
R1,249 Discovery Miles 12 490 Ships in 12 - 17 working days

For two decades, Understanding Clinical Papers has been helping students and professionals understand the research that supports evidence-based practice. Now in its fourth edition, this popular introductory textbook covers every major aspect of reading and evaluating clinical research literature, from identifying the aims and objectives of a paper to analysing the data with different multivariable methods. Numerous excerpts from actual clinical research papers make learning real and immediate, supported by a unique visual approach that reinforces key points and connects examples with the chapter material. The fourth edition includes extensively revised content throughout, including four brand-new chapters covering qualitative studies, Poisson regression, studies of complex interventions, and research using previously collected data. New and updated material discusses the difference between clinical and statistical significance, the consequences of multiple testing and methods of correction, how topic guides are used to explore and explain participants' experiences, standardised guidelines for writing trials and reviews, and much more. Offering clear explanations of important research-related topics, this reader-friendly resource: Offers a clear, concise, and accessible approach to learning how to read and analyse clinical research literature Features new coverage of qualitative research, including descriptive studies, sampling and populations, and identifying, summarising, and measuring qualitative characteristics Provides new material on missing data, sub-group analysis, feasibility and pilot studies, cluster randomised trials, and adaptive trial designs Includes new tables, abstracts, and excerpts from recent clinical research literature Understanding Clinical Papers is essential reading for all healthcare professionals and students, particularly those involved in clinical work and medical research, as well as general readers wanting to improve their understanding of research literature.

A Concise Introduction to Mixed Methods Research - International Student Edition (Paperback, 2nd Revised edition): John W.... A Concise Introduction to Mixed Methods Research - International Student Edition (Paperback, 2nd Revised edition)
John W. Creswell
R658 Discovery Miles 6 580 Ships in 12 - 17 working days

For students and researchers new to mixed methods, A Concise Introduction to Mixed Methods Research 2e by renowned author John W. Creswell provides a brief and practical introduction to mixed methods. Many graduate students and researchers in the social, behavioral and health sciences may not have the time or resources to read long treatises or stacks of journal articles on mixed methods research. This text quickly describes the basics of setting up and conducting a study using this methodology. Chapters are short and follow the process of research, from ensuring skills for conducting research, acknowledging the steps in planning a study, designing studies with increasing complexity, planning sampling strategies and integration, and writing up the results of your study. Get started in mixed methods quickly with this brief primer.

Science of Ashwagandha: Preventive and Therapeutic Potentials (Hardcover, 1st ed. 2017): Sunil C. Kaul, Renu Wadhwa Science of Ashwagandha: Preventive and Therapeutic Potentials (Hardcover, 1st ed. 2017)
Sunil C. Kaul, Renu Wadhwa
R5,771 Discovery Miles 57 710 Ships in 10 - 15 working days

Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body's defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities.

Bad Pharma - How Medicine is Broken, and How We Can Fix it (Paperback): Ben Goldacre Bad Pharma - How Medicine is Broken, and How We Can Fix it (Paperback)
Ben Goldacre 1
R367 R303 Discovery Miles 3 030 Save R64 (17%) Ships in 12 - 17 working days

'Bad Science' hilariously exposed the tricks that quacks and journalists use to distort science, becoming a 400,000 copy bestseller. Now Ben Goldacre puts the $600bn global pharmaceutical industry under the microscope. What he reveals is a fascinating, terrifying mess. Doctors and patients need good scientific evidence to make informed decisions. But instead, companies run bad trials on their own drugs, which distort and exaggerate the benefits by design. When these trials produce unflattering results, the data is simply buried. All of this is perfectly legal. In fact, even government regulators withhold vitally important data from the people who need it most. Doctors and patient groups have stood by too, and failed to protect us. Instead, they take money and favours, in a world so fractured that medics and nurses are now educated by the drugs industry. The result: patients are harmed in huge numbers. Ben Goldacre is Britain's finest writer on the science behind medicine, and 'Bad Pharma' is the book that finally prompted Parliament to ask why all trial results aren't made publicly available - this edition has been updated with the latest news from the select committee hearings. Let the witty and indefatigable Goldacre show you how medicine went wrong, and what you can do to mend it.

Therapeutic Platform of Bioactive Lipids - Focus on Cancer (Hardcover): Manjari Singh Therapeutic Platform of Bioactive Lipids - Focus on Cancer (Hardcover)
Manjari Singh
R3,936 Discovery Miles 39 360 Ships in 12 - 17 working days

Bioactive lipid metabolism and signaling are now widely accepted as major players in cancer biology. This volume helps to fill the urgent need to explore and investigate the innovations, current shortcomings, and future challenges of cancer therapy through the bioactive lipids by presenting new research on the use of bioactive lipids as effective weapons against cancer. The volume introduces the subject and then goes on to cover the chemistry, formulation, and mechanism of bioactive lipids in cancer. The volume takes a close look at lipoxins, ceramides, resolvins, and sphingosine-1-phosphate and their roles in cancer treatment. It also addresses the formulations based on bioactive lipids for the treatment of cancer. A variety of mechanisms of bioactive lipids as novel therapies are also covered, including using computational techniques to identify bioactive lipid drug targets, targeting therapy via KRAS and PI3K signals, and others. The authors also discuss the role and effects of various substances and their effect on various cancers, including colorectal cancer, prostate cancer, breast cancer, and others. The application of lysophosphatidic acid, lipopolysaccharide, lipid-soluble bioactive substance from avocado, omega-3 polyunsaturated fatty acids-derived lipid metabolites, and more are covered as well. The volume offers academia, technologists, and scientists from different disciplines valuable information to gain knowledge of bioactive lipid metabolism and signaling as an anti-cancer weapon in their fight against cancer.

Synopsis of Key Gynecologic Oncology Trials (Paperback, 2nd edition): Malte Renz, Elisabeth Diver, Whitfield Growdon, Oliver... Synopsis of Key Gynecologic Oncology Trials (Paperback, 2nd edition)
Malte Renz, Elisabeth Diver, Whitfield Growdon, Oliver Dorigo
R1,378 Discovery Miles 13 780 Ships in 9 - 15 working days

Gives a convenient summary of trials in Gynecologic Oncology Supplies an invaluable revision primer for those undertaking certification Provides a uniquely up-to-date resource

Atlas of FFR-Guided Percutaneous Coronary Interventions (Hardcover, 1st ed. 2016): Tommaso Gori, Massimo Fineschi Atlas of FFR-Guided Percutaneous Coronary Interventions (Hardcover, 1st ed. 2016)
Tommaso Gori, Massimo Fineschi
R6,949 Discovery Miles 69 490 Ships in 12 - 17 working days

This book reviews the theory and practice of fractional flow reserve (FFR)-guided coronary intervention, a technique that gives sense and a rationale to daily decisions in the interventional suite. FFR guidance provides detailed information on coronary hemodynamics for the interventional cardiologist. This technique has profound practical implications for therapeutic decisions and for the prognosis of patients. The Atlas of FFR-Guided Percutaneous Coronary Interventions provides practicing physicians clear information to understand both the complexity of the technique and the correct way to apply it. It is designed both to assist younger faculty and those in training, and to act as a clinical resource for more experienced practitioners. Using the clinical cases outlined, the reader can learn to appreciate the pitfalls, tips and tricks that simplify the performance and interpretation of FFR and iFR.

Plague - One Scientist's Intrepid Search for the Truth about Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS),... Plague - One Scientist's Intrepid Search for the Truth about Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism, and Other Diseases (Paperback)
Kent Heckenlively, Judy Mikovits
R573 R488 Discovery Miles 4 880 Save R85 (15%) Ships in 10 - 15 working days

#10 on Amazon Charts, USA Today Bestseller "This book is my best attempt to tell the truth about my research, the culture in science today which is hostile to new ideas, and what science can really do if allowed to pursue promising areas of inquiries."-Dr. Judy Mikovits, PhD This is a story for anybody interested in the peril and promise of science at the very highest levels in our country. On July 22, 2009, a special meeting was held with twenty-four leading scientists at the National Institutes of Health to discuss early findings that a newly discovered retrovirus was linked to chronic fatigue syndrome (CFS), prostate cancer, lymphoma, and eventually neurodevelopmental disorders in children. When Dr. Judy Mikovits finished her presentation, the room was silent for a moment, then one of the scientists said, "Oh my God!" The resulting investigation would be like no other in science. For Dr. Mikovits, a twenty-year veteran of the National Cancer Institute, this was the midpoint of a five-year journey that would start with the founding of the Whittemore-Peterson Institute for Neuro-Immune Disease at the University of Nevada, Reno, and end with her as a witness for the federal government against her former employer, Harvey Whittemore, for illegal campaign contributions to Senate Majority Leader Harry Reid. On this journey Dr. Mikovits would face the scientific prejudices against CFS, wander into the minefield that is autism, and through it all struggle to maintain her faith in God and the profession to which she had dedicated her life.

Tissue Repair - Reinforced Scaffolds (Hardcover, 1st ed. 2017): Xiao-Ming Li Tissue Repair - Reinforced Scaffolds (Hardcover, 1st ed. 2017)
Xiao-Ming Li
R4,440 Discovery Miles 44 400 Ships in 10 - 15 working days

This book summarizes the effective reinforcement of scaffolds by means of different kinds of fibers and tubes to meet different needs in the context of tissue repair. It covers the fabrication of the reinforced scaffolds, the factors influencing their properties, and their applications for hard and soft tissue repair. Further, it presents a range of concrete examples, case studies and research frontiers, providing readers a better understanding of how the respective fibers or tubes influence the mechanical properties, biodegradability, biocompatibility and bioactivity of scaffolds, and how they fulfill specific medical requirements. As such, the book provides a valuable and informative resource for researchers, technicians and students in the fields of biomaterials, tissue engineering and regenerative medicine.

Skin Stress Response Pathways - Environmental Factors and Molecular Opportunities (Hardcover, 1st ed. 2016): Georg T. Wondrak Skin Stress Response Pathways - Environmental Factors and Molecular Opportunities (Hardcover, 1st ed. 2016)
Georg T. Wondrak
R6,538 Discovery Miles 65 380 Ships in 12 - 17 working days

It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.

Reviews in Plasmonics 2015 (Hardcover, 1st ed. 2016): Chris D. Geddes Reviews in Plasmonics 2015 (Hardcover, 1st ed. 2016)
Chris D. Geddes
R5,885 Discovery Miles 58 850 Ships in 12 - 17 working days

Reviews in Plasmonics 2015, the second volume of the new book series from Springer, serves as a comprehensive collection of current trends and emerging hot topics in the field of Plasmonics and closely related disciplines. It summarizes the year's progress in surface plasmon phenomena and its applications, with authoritative analytical reviews in sufficient detail to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of Plasmonics. Reviews in Plasmonics offers an essential source of reference material for any lab working in the Plasmonics field and related areas. All academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of Plasmonics will find it an invaluable resource.

Handbook of Analysis of Oligonucleotides and Related Products (Paperback): Jose V. Bonilla, G. Susan Srivatsa Handbook of Analysis of Oligonucleotides and Related Products (Paperback)
Jose V. Bonilla, G. Susan Srivatsa
R2,473 Discovery Miles 24 730 Ships in 12 - 17 working days

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

Vital Organs (Hardcover): Suzie Edge Vital Organs (Hardcover)
Suzie Edge
R587 R480 Discovery Miles 4 800 Save R107 (18%) Ships in 9 - 15 working days

From Napoleon's penis to Van Gogh's ear, from Marie Antoinette's teeth to Marie Curie's bone marrow, this book brings together the remarkable stories of body parts that have made history. We have always used and abused bodies. We've torn them apart, dug them up, experimented on them or taken bits home to display as trophies. Body parts have been used for propaganda in wars and pulled off in punishment. They've answered medical mysteries, been turned into relics and even saved lives. Now TikTok sensation and medical historian, Dr Suzie Edge, brings us a history of the world's most famous body parts told through its most notable limbs, organs, and appendages, including how Queen Victoria's armpit led the development of antiseptics; why Percy Shelley's heart refused to burn; and the strange case of Hitler's right testicle.

The Cytoskeleton in Health and Disease (Hardcover, 1st ed. 2015): Heide Schatten The Cytoskeleton in Health and Disease (Hardcover, 1st ed. 2015)
Heide Schatten
R5,563 Discovery Miles 55 630 Ships in 12 - 17 working days

This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.

Regenerative Medicine - from Protocol to Patient - 1. Biology of Tissue Regeneration (Hardcover, 3rd ed. 2016): Gustav Steinhoff Regenerative Medicine - from Protocol to Patient - 1. Biology of Tissue Regeneration (Hardcover, 3rd ed. 2016)
Gustav Steinhoff
R2,981 Discovery Miles 29 810 Ships in 10 - 15 working days

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology, as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 1 contains eleven chapters addressing the latest basic science knowledge on the "Biology of Tissue Regeneration". The principles of cell regeneration control by extracellular matrix and the biology of stem cell niches are explained. Depicted are the principles of molecular mechanisms controlling asymmetric cell division, stem cell differentiation, developmental and regenerative biology, epigenetic and genetic control as well as mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are outlined. These up to date accounts gives the readers advanced insights into the biological principles of the regenerative processes in stem cells, tissues and organisms.

Human Embryonic Stem Cell Protocols (Hardcover, 3rd ed. 2015): Kursad Turksen Human Embryonic Stem Cell Protocols (Hardcover, 3rd ed. 2015)
Kursad Turksen
R3,060 Discovery Miles 30 600 Ships in 10 - 15 working days

The potential of human embryonic stem cells to advance not only regenerative medicine applications but also our fundamental understanding of stem cell biology continues to drive interest in research with these cells. This detailed volume collects some of the most interesting and useful protocols that have emerged in the area over the last several years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Human Embryonic Stem Cell Protocols, Third Edition serves as a valuable resource to all those interested in exploring stem cell biology questions in a research setting.

Tinnitus and Stress - An Interdisciplinary Companion for Healthcare Professionals (Hardcover, 1st ed. 2017): Agnieszka J.... Tinnitus and Stress - An Interdisciplinary Companion for Healthcare Professionals (Hardcover, 1st ed. 2017)
Agnieszka J. Szczepek, Birgit Mazurek
R2,660 Discovery Miles 26 600 Ships in 10 - 15 working days

This book provides up-to-date scientific information on the pathways by which psychosocial stress can affect the auditory system and describes current approaches to the management of patients with stress-related tinnitus. The latest evidence is presented on aspects such as the role of stress hormones in auditory function, the effects of allostatic load, circadian sensitivity to auditory trauma, and the association between stress-related biomarkers and tinnitus. The clinically oriented chapters discuss psychometric instruments of value in the tinnitus clinic and present stress-related tinnitus treatment protocols and outcome measures. It is widely acknowledged that the tinnitus percept acts as a stressor. However, it is also now evident that psychosocial stress can play a causative role in tinnitus and that the impact varies according to the level, duration, and quality of the stress. Assessment of the types and levels of stress in tinnitus patients before, during, and after treatment is therefore very important. Healthcare professionals attending tinnitus patients will benefit from the information that this book provides on the relationship between tinnitus and stress and from the practical guidance that it offers.

The Midlife Cyclist - The Road Map for the +40 Rider Who Wants to Train Hard, Ride Fast and Stay Healthy (Paperback): Phil... The Midlife Cyclist - The Road Map for the +40 Rider Who Wants to Train Hard, Ride Fast and Stay Healthy (Paperback)
Phil Cavell
R390 Discovery Miles 3 900 Ships in 12 - 17 working days

'I am blown away by the level of detail Phil Cavell brings to his work.' - Elinor Barker MBE, multiple world champion and Olympic gold medallist 'The Midlife Cyclist is a triumph' - Cycling Plus 'An amazing accomplishment... a simple-to-understand precis of your midlife as a cyclist - you won't want to put it down.' - Phil Liggett, TV cycling commentator 'Phil is eminently qualified to write The Midlife Cyclist. Well, he is certainly old enough.' - Fabian Cancellara, Tour de France rider and two-time Olympic champion Renowned cycling biomechanics pioneer, Phil Cavell, explores the growing trend of middle-aged and older cyclists seeking to achieve high-level performance. Using contributions from leading coaches, ex-professionals and pro-team doctors, he produces the ultimate manifesto for mature riders who want to stay healthy, avoid injury - and maximise their achievement levels. Time's arrow traditionally plots an incremental path into declining strength and speed for all of us. But we are different to every other generation of cyclists in human history. An ever-growing number of us are determined to scale the highest peaks of elite physical fitness into middle-age and beyond. Can the emerging medical and scientific research help us achieve the holy triumvirate of speed and health with age? The Midlife Cyclist offers a gold standard road-map for the mature cyclist who aims to train, perform and even race at the highest possible level.

Biobetters - Protein Engineering to Approach the Curative (Hardcover, 1st ed. 2015): Amy Rosenberg, Barthelemy Demeule Biobetters - Protein Engineering to Approach the Curative (Hardcover, 1st ed. 2015)
Amy Rosenberg, Barthelemy Demeule
R5,548 Discovery Miles 55 480 Ships in 12 - 17 working days

"Biobetters: Protein Engineering to Approach the Curative" discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, "closer to a cure" as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.

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