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Books > Medicine > General issues > Medical equipment & techniques > Medical research

Decision Making in a World of Comparative Effectiveness Research - A Practical Guide (Hardcover, 1st ed. 2017): Howard G.... Decision Making in a World of Comparative Effectiveness Research - A Practical Guide (Hardcover, 1st ed. 2017)
Howard G. Birnbaum, Paul E. Greenberg
R3,904 R3,699 Discovery Miles 36 990 Save R205 (5%) Ships in 12 - 17 working days

In the past decade there has been a worldwide evolution in evidence-based medicine that focuses on real-world Comparative Effectiveness Research (CER) to compare the effects of one medical treatment versus another in real world settings. While most of this burgeoning literature has focused on research findings, data and methods, Howard Birnbaum and Paul Greenberg (both of Analysis Group) have edited a book that provides a practical guide to decision making using the results of analysis and interpretation of CER. Decision Making in a World of Comparative Effectiveness contains chapters by senior industry executives, key opinion leaders, accomplished researchers, and leading attorneys involved in resolving disputes in the life sciences industry. The book is aimed at 'users' and 'decision makers' involved in the life sciences industry rather than those doing the actual research. This book appeals to those who commission CER within the life sciences industry (pharmaceutical, biologic, and device manufacturers), government (both public and private payers), as well as decision makers of all levels, both in the US and globally.

Current Treatment Options for Fuchs Endothelial Dystrophy (Hardcover, 1st ed. 2017): Claus Cursiefen, Albert S. Jun Current Treatment Options for Fuchs Endothelial Dystrophy (Hardcover, 1st ed. 2017)
Claus Cursiefen, Albert S. Jun
R5,299 Discovery Miles 52 990 Ships in 12 - 17 working days

This book provides state of the art information on modern minimally invasive lamellar transplant techniques for Fuchs endothelial dystrophy (FED), such as Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). In addition to clear step-by-step descriptions of procedures, guidance is offered on donor tissue preparation, potential intra- and postoperative complications, and complication management. Future treatment options in the form of medical, cell-based approaches are also discussed. To complete the picture, relevant information is included on the pathophysiology, clinical features, and differential diagnosis of FED. This book will be of interest to all who wish to learn about the dramatic developments in corneal transplantation and medical treatment that are transforming the management of FED.

Nursing and Health Care Research (Paperback, 2nd New edition): Collette Clifford, Stephen Gough Nursing and Health Care Research (Paperback, 2nd New edition)
Collette Clifford, Stephen Gough
R1,214 R449 Discovery Miles 4 490 Save R765 (63%) Ships in 12 - 17 working days

A guide to nursing and health care, this book aims to take more account of health care professionals outside nursing and pay more attention to qualitative research and increased consideration of how to develop reliability and validity in research tools.

Cutaneous Infection and Therapy (Hardcover): Raza Aly Cutaneous Infection and Therapy (Hardcover)
Raza Aly
R2,597 Discovery Miles 25 970 Ships in 10 - 15 working days

This unique reference provides concise, single-source coverage of the clinical, research, and therapeutic aspects of dermatological problems associated with bacteria, fungi, and viruses.
Introduces many novel antifungal, antibacterial, and antiviral agents
Highlighting the molecular biology as well as risk - benefit ratios of new diagnostic and treatment modalities, Cutaneous Infection and Therapy
evaluates the role of antimicrobial soaps in personal hygiene and research on preoperative skin preparation and infection rates
discusses reasons for the reduced risk of infection using occlusive wound dressings
explains the epidemiology, presentation, pathophysiology, and treatment of athlete's foot and fungal diseases of the scalp
presents new oral antifungals for the treatment of onychomycosis
examines the advantages and disadvantages of preparations to treat superficial fungal infections
addresses oral candidiasis in HIV infection and the resistance to antifungal therapy in AIDS patients
reviews the patterns of candidiasis in children and current approaches to antifungal therapy
covers the epidemiology, implications, and management of herpes in pregnant women and newborns
and much more

Brute Science - Dilemmas of Animal Experimentation (Hardcover): Hugh LaFollette, Niall Shanks Brute Science - Dilemmas of Animal Experimentation (Hardcover)
Hugh LaFollette, Niall Shanks
R3,909 Discovery Miles 39 090 Ships in 12 - 17 working days

Animal experimentation is one of the most controversial areas of debate on animal rights. Biomedical research is at the hard edge of these debates: it throws up fundamental questions of moral value - of whether human life is more important than that of animals. Much experimentation is defended by its apparent success in terms of increasing medical knowledge. This study investigates whether biomedical research using animals is, in fact, scientifically justified. The authors show that in scientific terms - using the models that scientists themselves use - these claims are exaggerated, or even false. They argue that we need to reassess our use of animals and, indeed, rethink the standard positions in the debate. Their analysis reveals why research using animals might be a source of hypotheses about human biomedical phenomena, yet would never prove or establish anything about this phenomena.

Trace Elements in Laboratory Rodents (Hardcover): Ronald R. Watson Trace Elements in Laboratory Rodents (Hardcover)
Ronald R. Watson
R4,229 Discovery Miles 42 290 Ships in 12 - 17 working days

Written by the international community's leading experts, Trace Elements in Laboratory Rodents describes the best and most current methods to provide deficient or supplemental trace elements to laboratory animals, as well as how to assay them. The experts warn of the common pitfalls and hidden problems in nutritional testing and how to avoid them. This how-to approach focuses on the technical details that make good, reliable studies. Common as well as rare or recently recognized minerals are described relating to both dietary supplementation and measurement in tissues.
If you are a researcher, professor, or student working in nutrition, food science, biochemistry, or veterinary medicine, you can't afford to be without this excellent hands-on methods manual!

Exploring Poisonous Plants - Medicinal Values, Toxicity Responses, and Therapeutic Uses (Hardcover): Azamal Husen Exploring Poisonous Plants - Medicinal Values, Toxicity Responses, and Therapeutic Uses (Hardcover)
Azamal Husen
R4,658 Discovery Miles 46 580 Ships in 12 - 17 working days

There is no current book is available in the market explaining medicinal values, toxicity responses, and other potential uses of poisonous plants exclusively. In recent years, extensive attention has been paid towards the up-gradation of medicinal and herbal plants therefore; this book includes important chapters on relevant topics. Audience - Those who are working on or have an interest in modern research especially in medicinal, herbal, and poisonous plants and is also useful for some pharmaceutical companies involved in herbal drug preparation.

Basic Methods Handbook for Clinical Orthopaedic Research - A Practical Guide and Case Based Research Approach (Hardcover, 1st... Basic Methods Handbook for Clinical Orthopaedic Research - A Practical Guide and Case Based Research Approach (Hardcover, 1st ed. 2019)
Volker Musahl, Jon Karlsson, Michael T. Hirschmann, Olufemi R. Ayeni, Robert G. Marx, …
R4,736 R4,007 Discovery Miles 40 070 Save R729 (15%) Ships in 12 - 17 working days

This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.

Systemic, Cellular & Molecular Mechanisms of Physiological Functions & Their Disorders - Proceedings of I Beritashvili Center... Systemic, Cellular & Molecular Mechanisms of Physiological Functions & Their Disorders - Proceedings of I Beritashvili Center for Experimental Biomedicine 2015 (Hardcover)
Nodar P. Mitagvaria
R6,367 R5,751 Discovery Miles 57 510 Save R616 (10%) Ships in 12 - 17 working days

This book presents results of current research conducted in the I. Beritashvili Center of Experimental Biomedicine (former I. Beritashvili Institute of Physiology, Tbilisi, Georgia) and is devoted to the experimental investigation of systemic, cellular and molecular mechanisms of physiological functions and their disorders in pathology. More precisely, the results of the following studies are described and discussed: The new, original theory of the fourth main state of an organisms vitality; memory impairments following excitotoxic lesions; biologically positive behavioral indices of the transition state, caused by informational stress and their pharmacological regulation; functioning of mechanisms responsible for perception constancy; peculiarities of EEG characteristics in individuals with attention deficit hyperactivity disorder; neuroanatomy and neurochemistry of the basic mechanisms for neocortical and hippocampal arousal; changes in learning ability and induction of aggressive behavior caused by manganese loading and ionising radiation; hippocampal activity during learning in different behavioral paradigms; molecular mechanism of PARP-1 action; significance of the diencephalic GABAergic neurons in normal and pathological activity of the brain; cellular mechanisms of antinociceptive tolerance; thermal stability of model globular protein; kinetic features of transport ATPases; antiseizure drugs and EEG in epileptic patients; effect of depakin on EEG epileptiform elements; how six domains form one enzyme; therapeutic potential of extracellular ubiquitin; effect of toluene chronic exposure on hippocampal structure; and the mechanisms of local hyperthermia caused by morphological changes in cerebral tissue.

Immunogold-Silver Staining - Principles, Methods, and Applications (Hardcover): Horace H. Loh Immunogold-Silver Staining - Principles, Methods, and Applications (Hardcover)
Horace H. Loh; Edited by M. A. Hayat; Contributions by Heinz Schwarz, Ann M. Dvorak, Johnson K. Gao, …
R9,099 R3,181 Discovery Miles 31 810 Save R5,918 (65%) Ships in 12 - 17 working days

This is the first book devoted exclusively to the subject of immunogold-silver staining. This volume is authored by 47 distinguished scientist representing 12 countries. The primary objective of this book is to discuss principles, methods, and applications of IGSS.

Foundations of Clinical Research - Applications to Evidence-Based Practice (Hardcover, 4th Revised edition): Leslie G Portney Foundations of Clinical Research - Applications to Evidence-Based Practice (Hardcover, 4th Revised edition)
Leslie G Portney
R2,985 Discovery Miles 29 850 Ships in 12 - 17 working days

Become a successful evidence-based practitioner How do you evaluate the evidence? Is the information accurate, relevant and meaningful for clinical decision making? Did the design fit the research questions and was the analysis and interpretation of data appropriate? Here are all the materials you need to take your first steps as evidence-based practitioners...how to use the design, data and analysis of research as the foundation for effective clinical decision making. You'll find support every step of the way as you progress from the foundations of clinical research and concepts of measurement through the processes of designing studies and analyzing data to writing their own research proposal. Updated examples to provide students with a relevant context for understanding designs and analyses Conceptual description of analytic procedures used in evidence-based practice as well as tables to demonstrate simple calculations Algorithm for choosing a statistical procedure based on a study's design Diagrams that aim to assist in a student's understanding of experimental and observational design variations Guidelines for critical appraisal of various types of studies Strong emphasis on evidence-based practice, including a focus on sensitivity/specificity and likelihood ratios, number needed to treat, measuring clinically meaningful change Instructor resources: Ebook

Monoclonal Antibodies - The Second Generation (Hardcover): Heddy Zola Monoclonal Antibodies - The Second Generation (Hardcover)
Heddy Zola
R2,398 Discovery Miles 23 980 Ships in 10 - 15 working days

This is a review of what needs to be done to realize the potential of monoclonal antibodies. It assesses the competing technologies with advice on the best approach for a particular situation. Monoclonal antibodies have revolutionized immunology and are now promising to have a similar impact on clinical medicine. Recent developments should overcome many of the difficulties experienced in the past which has seen a great deal of talk about the therapeutic applications of monoclonal antibodies, but very little routine therapy.

Fetal Development - A Psychobiological Perspective (Hardcover, Revised): Jean-Pierre Lecanuet, William P. Fifer, Norman A.... Fetal Development - A Psychobiological Perspective (Hardcover, Revised)
Jean-Pierre Lecanuet, William P. Fifer, Norman A. Krasnegor, William P. Smotherman
R3,960 Discovery Miles 39 600 Ships in 12 - 17 working days

Based on the presentations given by well-known specialists at a recent multidisciplinary conference of developmental psychobiologists, obstetricians, and physiologists, this book is the first exhaustive attempt to synthesize the present scientific knowledge on fetal behavior. Utilizing a psychobiological analytic approach, it provides the reader with an overview of the perspectives, hypotheses, and experimental results from a group of basic scientists and clinicians who conduct research to elucidate the role of fetal behavior in development. Experimental and clinical as well as human and animal data are explored via comparative developmental analysis. The ontogeny of fetal spontaneous activity -- via the maturation of "behavioral states" -- and of fetal responsiveness to sensory stimulation is studied in detail. Results are provided from studies of embryonic/fetal and newborn behavior in chicks, rats, sheep, primates, and humans. Knowledge of fetal behavior is crucial to the obstetrician, neonatologist, developmental psychologist, and even the future parents, in order to follow and assess the gradual development of spontaneous responsive movements of the fetus. While assessing this important information, this text also examines the neuro-behavioral events taking place during the fetal period as an aid to understanding normal and pathological life span development.

Statistical Bases of Reference Values in Laboratory Medicine (Hardcover): Eugene K. Harris, James C. Boyd Statistical Bases of Reference Values in Laboratory Medicine (Hardcover)
Eugene K. Harris, James C. Boyd
R8,924 Discovery Miles 89 240 Ships in 12 - 17 working days

Examining the strengths and limitations of various standards of accuracy in clinical laboratory analyses, this detailed reference presents an in-depth study of important theoretical and empirical issues concerning the description, collection, and application of reference values in laboratory medicine.

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials (Hardcover): Toshiro Tango Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials (Hardcover)
Toshiro Tango
R2,660 Discovery Miles 26 600 Ships in 12 - 17 working days

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The author introduces a new repeated measures design called S:T design combined with mixed models as a practical and useful framework of parallel group RCT design because of easy handling of missing data and sample size reduction. The book emphasizes practical, rather than theoretical, aspects of statistical analyses and the interpretation of results. It includes chapters in which the author describes some old-fashioned analysis designs that have been in the literature and compares the results with those obtained from the corresponding mixed models. The book will be of interest to biostatisticians, researchers, and graduate students in the medical and health sciences who are involved in clinical trials. Author Website:Data sets and programs used in the book are available at http://www.medstat.jp/downloadrepeatedcrc.html

Handbook on Immunosenescence - basic understanding and clinical applications (Hardcover, 2009 ed.): Tamas Fulop, Claudio... Handbook on Immunosenescence - basic understanding and clinical applications (Hardcover, 2009 ed.)
Tamas Fulop, Claudio Franceschi, Katsuiki Hirokawa, Graham Pawelec
R8,835 Discovery Miles 88 350 Ships in 10 - 15 working days

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Handbook of Mouse Mutations with Skin and Hair Abnormalities - Animal Models and Biomedical Tools (Hardcover): John P. Sundberg Handbook of Mouse Mutations with Skin and Hair Abnormalities - Animal Models and Biomedical Tools (Hardcover)
John P. Sundberg
R5,771 Discovery Miles 57 710 Ships in 10 - 15 working days

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Molecular Targeted Therapy of Lung Cancer (Hardcover, 1st ed. 2017): Yuichi Takiguchi Molecular Targeted Therapy of Lung Cancer (Hardcover, 1st ed. 2017)
Yuichi Takiguchi
R5,488 Discovery Miles 54 880 Ships in 12 - 17 working days

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Benefit-Risk Assessment Methods in Medical Product Development - Bridging Qualitative and Quantitative Assessments (Hardcover):... Benefit-Risk Assessment Methods in Medical Product Development - Bridging Qualitative and Quantitative Assessments (Hardcover)
Qi Jiang, Weili He
R2,763 Discovery Miles 27 630 Ships in 12 - 17 working days

Guides You on the Development and Implementation of B-R Evaluations Benefit-Risk Assessment Methods in Medical Product Development: Bridging Qualitative and Quantitative Assessments provides general guidance and case studies to aid practitioners in selecting specific benefit-risk (B-R) frameworks and quantitative methods. Leading experts from industry, regulatory agencies, and academia present practical examples, lessons learned, and best practices that illustrate how to conduct structured B-R assessment in clinical development and regulatory submission. The first section of the book discusses the role of B-R assessments in medicine development and regulation, the need for both a common B-R framework and patient input into B-R decisions, and future directions. The second section focuses on legislative and regulatory policy initiatives as well as decisions made at the U.S. FDA's Center for Devices and Radiological Health. The third section examines key elements of B-R evaluations in a product's life cycle, such as uncertainty evaluation and quantification, quantifying patient B-R trade-off preferences, ways to identify subgroups with the best B-R profiles, and data sources used to assist B-R assessment. The fourth section equips practitioners with tools to conduct B-R evaluations, including assessment methodologies, a quantitative joint modeling and joint evaluation framework, and several visualization tools. The final section presents a rich collection of case studies. With top specialists sharing their in-depth knowledge, thought-provoking considerations, and practical advice, this book offers comprehensive coverage of B-R evaluation methods, tools, and case studies. It gives practitioners a much-needed toolkit to develop and conduct their own B-R evaluations.

Quality of Life in Behavioral Medicine Research (Paperback): Joel E. Dimsdale, Andrew S. Baum Quality of Life in Behavioral Medicine Research (Paperback)
Joel E. Dimsdale, Andrew S. Baum
R1,034 Discovery Miles 10 340 Ships in 12 - 17 working days

The number of, and interest in, quality of life studies has grown dramatically in the last decade. On an ever increasing basis, patients, clinicians, researchers, and health policy regulators are considering quality of life in assessing treatment alternatives. Unfortunately, most discussions of quality of life are narrow in scope -- applying to only one disease group. This unique book represents the concerted effort of experts in academia, federal government health care regulators, and pharmaceutical industry representatives to define the promise and the problems associated with quality of life studies. The issues covered range from cross cutting ones to those that are specific to particular illnesses. Because quality of life takes into consideration such domains as mood, vocation, family, sexual functioning, social participation, and costs, this book will serve as an invaluable companion to readers with an interest in behavioral medicine research.

DMT: The Spirit Molecule (Paperback, Original): DMT: The Spirit Molecule (Paperback, Original)
2
R471 R321 Discovery Miles 3 210 Save R150 (32%) Ships in 12 - 17 working days

A clinical psychiatrist explores the effects of DMT, one of the most powerful psychedelics known.

- A behind-the-scenes look at the cutting edge of psychedelic research.

- Provides a unique scientific explanation for the phenomenon of alien abduction experiences.

From 1990 to 1995 Dr. Rick Strassman conducted U.S. Government-approved and funded clinical research at the University of New Mexico in which he injected sixty volunteers with DMT, one of the most powerful psychedelics known. His detailed account of those sessions is an extraordinarily riveting inquiry into the nature of the human mind and the therapeutic potential of psychedelics. DMT, a plant-derived chemical found in the psychedelic Amazon brew, ayahuasca, is also manufactured by the human brain. In Strassman's volunteers, it consistently produced near-death and mystical experiences. Many reported convincing encounters with intelligent nonhuman presences, aliens, angels, and spirits. Nearly all felt that the sessions were among the most profound experiences of their lives.

Strassman's research connects DMT with the pineal gland, considered by Hindus to be the site of the seventh chakra and by Rene Descartes to be the seat of the soul. DMT: The Spirit Molecule makes the bold case that DMT, naturally released by the pineal gland, facilitates the soul's movement in and out of the body and is an integral part of the birth and death experiences, as well as the highest states of meditation and even sexual transcendence. Strassman also believes that "alien abduction experiences" are brought on by accidental releases of DMT. If used wisely, DMT could trigger a period of remarkable progress in the scientificexploration of the most mystical regions of the human mind and soul.

Retinoids in Oncology (Hardcover, illustrated edition): Waun Ki Hong, Reuben Lotan Retinoids in Oncology (Hardcover, illustrated edition)
Waun Ki Hong, Reuben Lotan
R5,388 Discovery Miles 53 880 Ships in 12 - 17 working days

This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues; addresses the mechanisms by which cultured keratinocytes respond to retinoids; considers the antitumor activity of combination therapy with retinoids and cytokines; reviews the toxicity profiles of the vitamin A molecule and the synthetically derived retinoid compounds and their effects on humans; examines the use of retinoids in the prevention of basal cell carcinoma and squamous cell carcinoma (SCC) and in the therapy of advanced SCC; and summarizes data on the potential of retinoids to prevent epithelial cancer, to act as adjuvants to current therapies in early stages of the disease and to aid in the management of both solid tumours and hematologic malignancies.;A guide for the many disciplines involved in the preclinical studies and direct care of cancer patients, this book serves as useful reading for clinical, surgical and radiation oncologists; clinical immunologists; dermatologists; obstetricians/gynaecologists; haematologists; otolaryngologists; internists; nutritionists; and pulmonary-disease specialists.

Advances in Medicine & Biology - Volume 87 (Hardcover): Leon V Berhardt Advances in Medicine & Biology - Volume 87 (Hardcover)
Leon V Berhardt
R5,727 Discovery Miles 57 270 Ships in 12 - 17 working days

This book presents the latest developments in medicine and biology. Chapters include research on trends in the birth prevalence of boys with isolated hypospadias and undescended testis in Hungary during the last 50 years; alleviating premenstrual syndrome (PMS) symptoms using a natural factor; neutralization-enhancing RF antibodies; advances in the diagnosis, assessment, management and outcome of Takayasu's arteritis; macronutrients and premenstrual syndrome; pressurised intraperitoneal aerosol chemotherapy (PIPAC); the control of MAO expression; and what we know about iMAO.

Imaging Drug Action in the Brain (Hardcover): James McCulloch Imaging Drug Action in the Brain (Hardcover)
James McCulloch; Edythe D. London
R13,302 Discovery Miles 133 020 Ships in 10 - 15 working days

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Researching Health Care - Designs, dilemmas, disciplines (Hardcover): Jeanne Daly, Ian McDonald, Evan Willis Researching Health Care - Designs, dilemmas, disciplines (Hardcover)
Jeanne Daly, Ian McDonald, Evan Willis
R5,221 Discovery Miles 52 210 Ships in 12 - 17 working days

Health care delivery is undergoing intense scrutiny and pressure for change: people have high expectations and want value for money. Research can do much to evaluate the effectiveness of health care, but deeply rooted disciplinary preconceptions - about what should be done and how, and about what is scientific - have hampered relevant research. "Researching Health Care" brings together an international team of health researchers from the fields of clinical care, clinical epidemiology, bio-statistics, sociology, health economics and health policy. The problem of research method is central to the evaluation of health care, and the contributors therefore focus on the three most important methods in use at present: experimental methods, surveys and other quantitative methods, and qualitative methods. The strengths and limitations of each method are spelled out, and the contributors show how some methods are more appropriate for evaluating the technical aspects of medicine, others for social and community issues. They argue that complex health care problems can be adequately addressed only by an equally broad range of research study designs, as well as by a willingness to co-operate. Th

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