Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Lipids in Protein Misfolding (Hardcover, 1st ed. 2015)
Loot Price: R5,933
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Lipids in Protein Misfolding (Hardcover, 1st ed. 2015)
Series: Advances in Experimental Medicine and Biology, 855
Expected to ship within 10 - 15 working days
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Protein conversion from a water-soluble native conformation to the
insoluble aggregates and fibrils, which can deposit in amyloid
plaques, underlies more than 20 human diseases, representing a
major public health problem and a scientific challenge. Such a
conversion is called protein misfolding. Protein misfolding can
also involve errors in the topology of the folded proteins and
their assembly in lipid membranes. Lipids are found in nearly all
amyloid deposits in vivo, and can critically influence protein
misfolding in vitro and in vivo in many different ways. This book
focuses on recent advances in our understanding of the role of
lipids in modulating the misfolding of various proteins. The main
emphasis is on the basic biophysical studies that address molecular
basis of protein misfolding and amyloid formation, and the role of
lipids in this complex process.
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