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Books > Medicine > General issues > Medical equipment & techniques > Medical research
This book follows 'The Unofficial Guide to Passing OSCEs'. It teaches all the skills expected of today's graduates, but omitted in the curriculum. It provides a systematic approach to teaching, research, and audits, including seizing opportunities to undertake these highly competitive activities. It contains checklists for analyzing research, tips for effective teaching, and guidance for portfolios, giving it relevance beyond examinations, in post graduate further education, and as a day-to-day reference.
Originally published in 1995, "Analysing Survival Data from Clinical Trials and Observational Studies" provides a thorough yet accessible overview of survival data analysis. It is written in a highly accessible style focussed on concepts and methods rather than theory, and includes careful explanation of the underlying statistical and medical principles. Now available in paperback, the book provides a comprehensive introduction to the subject suitable for graduate students of biostatistics and survival analysis. Provides a practical introduction to survival data analysis. Covers the core topics, including estimation of survival probabilities, as well as more advance topics, such as parametric regression models, competing risk and meta-analysis. Illustrates the methods using real data sets throughout. Written in a lucid style, suitable for students of biostatistics and survival analysis. Includes discussion of a range of software choices for applying the methods described. "Analysing Survival Data from Clinical Trials and Observational Studies" is ideally suited to graduate students studying courses in survival analysis. The wide range of examples and applications make it an ideal practical reference for researchers and practitioners working in survival analysis from statistics, medicine and epidemiology.
Thousands of people from more than eighty countries have traveled to China since 2001 to undergo fetal cell transplantation. Galvanized by the potential of stem and fetal cells to regenerate damaged neurons and restore lost bodily functions, people grappling with paralysis and neurodegenerative disorders have ignored the warnings of doctors and scientists back home in order to stake their futures on a Chinese experiment. Biomedical Odysseys looks at why and how these individuals have entrusted their lives to Chinese neurosurgeons operating on the forefront of experimental medicine, in a world where technologies and risks move faster than laws can keep pace. Priscilla Song shows how cutting-edge medicine is not just about the latest advances in biomedical science but also encompasses transformations in online patient activism, surgical intervention, and borderline experiments in health care bureaucracy. Bringing together a decade of ethnographic research in hospital wards, laboratories, and online patient discussion forums, Song opens up important theoretical and methodological horizons in the anthropology of science, technology, and medicine. She illuminates how poignant journeys in search of fetal cell cures become tangled in complex webs of digital mediation, the entrepreneurial logics of postsocialist medicine, and fraught debates about the ethics of clinical experimentation. Using innovative methods to track the border-crossing quests of Chinese clinicians and their patients from around the world, Biomedical Odysseys is the first book to map the transnational life of fetal cell therapies.
This practical 'How To' guide talks the reader step-by-step through designing, conducting and disseminating primary care research, a growing discipline internationally. The vast majority of health care issues are experienced by people in community settings, who are not adequately represented by hospital-based research. There is therefore a great need to upskill family physicians and other primary care workers and academics to conduct community-based research to inform best practice. Aimed at emerging researchers, including those in developing countries, this book also addresses cutting edge and newly developing research methods, which will be of equal interest to more experienced researchers.
"How to Survive Peer Review" is a practical handbook designed to help anybody who wants to get their work published in a scientific journal, wants to apply for research funds or who has to undergo formal appraisals at work. It will also help people who have been asked to review articles, abstracts or grant applications. These activities are an essential part of scientific life, yet they virtually never get covered in professional training. It is often difficult even to get any helpful information about the processes from journals, meetings or funders. For the first time, this book brings together all you need to know, with authoritative advice from three authors who have researched peer review extensively and have considerable practical experience as researchers, editors and reviewers.
This book introduces the fundamentals of biobanking and guides through the practical planning thereof, with a special focus on the situation in low- and middle-income countries. On the example of the setup of a Ukrainian biobank the book discusses the main steps and aspects of successful biorepository implementation and management. Topics covered include collection, storage and shipping of samples, establishment of an IT system, development of a sustainability plan, and project and risk management. Furthermore, the importance of the formation of international biobanking societies such as the Ukraine Association of Biobanks is highlighted, and their main objectives and tasks are discussed.The book addresses life science and business professionals as well as national authorities who are interested in biobanking in general and in setting up a biobank in particular.
The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism.
Qualitative Research for Allied Health Professionals - Challenging choices is a practical text, which addresses the links between philosophy, research method and practice in an accessible, readable way. The subtitle, Challenging Choices', carries a double meaning: qualitative research is both challenging (ie, demanding and stimulating) to undertake and likely to be challenged and contested. In particular, the choices researchers make when designing, carrying out and reporting research will attract scrutiny. To help researchers take on this double challenge, the book: Highlights some of the choices involved in carrying out qualitative research. Offers a wide range of practical examples to show how different ways of qualitative researched can be managed. Critically examines a variety if qualitative research methodologies of particular interest to allied health professionals. Clarifies the links between epistemology, methodology and method. This book is structured in three parts. Part 1 Sensitizes readers to the complex issue which challenge qualitative researchers at the planning stage of their projects. In part 2, the challenge of using different methodologies is critically explored by eleven authors who describe their individual research experiences. Part 3 examines the choices researchers make when they evaluate and present research.
Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines and for the testing of interventions to enhance the quality of these processes. The discipline is closely related and linked mainly to the broader field of pharmacoepidemiology, but also to health outcomes research, pharmacovigilance and health economics. Drug Utilization Research is a unique, practical guide to the assessment and evaluation of prescribing practices and to interventions to improve the use of medicines in populations. Edited by an international expert team from the International Society for Pharmacoepidemiology (ISPE), DUR is the only title to cover both the methodology and applications of drug utilization research and covers areas such as health policy, specific populations, therapeutics and adherence.
Assessment is arguably the most important stage of nursing. It forms the basis for any planned nursing intervention and a baseline against which subsequent events in the hospital stay can be compared. Assessment is an ongoing activity where the patient is continually reviewed and care reappraised to ensure that the patient's needs are being met. The main aim of this study is to evaluate the reliability and validity of the Byron Physical Assessment Framework (BPAF). the study involved scrutinising the BPAF to describe its purpose, conceptual basis and how it was developed. The BAF was then refined using extensive literature review and expert opinion to improve its comprehensiveness and clarity for its intended purpose. This monograph should be useful to all those attempting to construct and validate clinical assessment and measuring tools. Ruth Harris has the expertise necessary to do this in a sophisticated yet realistic way for practice colleagues.
Nanomedicine-Based Approaches for the Treatment of Dementia explores a wide range of promising approaches for the diagnosis and treatment of dementia. The book begins with introductory sections on dementia and brain ailments that are followed by further chapters that discuss detailed information about challenges of drug delivery across the blood-brain barrier as well as the current status. This book helps readers design and develop novel drug delivery systems and devices for the treatment of dementia that take advantage of recent advances in nanomedical technologies. Numerous drug delivery systems have been developed recently for dementia. Unfortunately, most of them are ineffective since dementia is not a single disease. It is an umbrella term for several neurodegenerative conditions which alter brain functions. Due to this, there is an urgent need for innovative technologies/nano drug delivery systems to improve the targeting and delivery of therapeutic as well as diagnostic agents specifically for treating dementia.
A single trial is complex, with numerous regulations, administrative processes, medical procedures, deadlines and specific protocol instructions to follow. And yet, there has existed no single-volume, comprehensive clinical research reference manual for investigators, medical institutions, and national and international research personnel to keep on the shelf as a ready reference to navigate through trial complexities and ensure compliance with U.S. Federal Regulations and ICH GCP until The Sourcebook for Clinical Research. An actionable, step-by-step guide through beginning to advanced topics in clinical research with forms, templates and checklists to download from a companion website, so that study teams will be compliant and will find all the necessary tools within this book. Additionally, the authors developed Display Posters for Adverse Events Plus Reporting and Medicare Coverage Analysis that can be purchased separately here: https://www.elsevier.com/books-and-journals/book-companion/9780128162422/order-display-posters. Moreover, The Sourcebook for Clinical Research contains clear information and guidance on the newest changes in the industry to keep seasoned investigators and staff current and compliant, in addition to providing detailed information regarding the most complex topics. This book serves as a quick, actionable, off-the-shelf resource to keep by your side at the medical clinic.
Do placebos work? For many conditions, you bet they do! Maybe in
some people most of the time; maybe even in all people some of the
time. Those are among the conclusions that experts drew from a
comprehensive review of placebo effects that took place at the
National Institutes of Health. The meeting, designed to bring basic
biomedical and behavioral scientists together with clinicians and
clinical trial experts, developed an expanded concept of the
placebo, explored a variety of explanatory mechanisms of why
placebos work when they work, and discussed the pros and cons of
using placebos in clinical trials. The experts went on to develop a
research agenda to further progress in the field. The result is a new look at placebos, one that calls for careful
consideration of the complex ethical issues involved in exploiting
placebo effects, but sees their potential as therapeutic allies in
clinical practice. The chapters serve as an essential practical and theoretical
guide to practitioners, researchers, bioethicists, patients, and
students who want a comprehensive review of the state of placebo
science and placebo-controlled clinical trials. They include: The publication of this book has importantimplications for clinical medicine, making it essential reading for clinical researchers, basic scientists and health care practitioners.
Health Data Processing: Systemic Approaches focuses on the design of health information systems and touches on the main themes of medical informatics and public health. The book is written for health professionals in practice or training, and is especially useful for decision-makers or future decision-makers in the field of health information systems. Users will find sections on the question of reusing data for other purposes, protection of individual liberties that this data and technologies make more acute, and the irruption of large masses of genetic data and its related problems. This book develops the methodological and conceptual aspects related to these issues.
"Quantitative Research Methods for Health Professionals: A Practical Interactive Course" is a superb introduction to epidemiology, biostatistics, and research methodology for the whole health care community. Drawing examples from a wide range of health research, this practical handbook covers important contemporary health research methods such as survival analysis, Cox regression, and meta-analysis, the understanding of which go beyond introductory concepts. The book includes self-assessment exercises throughout to help students explore and reflect on their understanding and a clear distinction is made between a) knowledge and concepts that all students should ensure they understand and b) those that can be pursued by students who wish to do so. The authors incorporate a program of practical exercises in SPSS using a prepared data set that helps to consolidate the theory and develop skills and confidence in data handling, analysis and interpretation.
The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjoegren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment.
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.
Learn how to evaluate and apply health sciences research with this beginner's guide! Reading Research: A User-Friendly Guide for Health Professionals, 7th Edition provides a clear introduction to reading and understanding research articles, with practical guidelines for implementing research into clinical practice. It describes how to interpret common research methods including qualitative, quantitative and mixed-method approaches, and explains how to find relevant, reliable research on the internet. Written by Barbara Davies and Jo Logan, both of whom are noted educators and research experts, this easy-to-use pocket guide is ideal for both students and health professionals. Concise overview of health sciences-related research maximizes your study time and makes it easier to understand qualitative, quantitative, and mixed-methods research. Succinct introduction to reading and understanding health sciences research articles is accompanied by practice worksheets and other learning resources on an Evolve website. Helpful guidelines suggest how to find interesting research results, identify how to use research results towards planning and delivering best practices and improving patient outcomes, and recommend actions to address barriers to using research in practice. UNIQUE! Tips boxes provide practical, easy-to-follow advice for those who are new to the subject. UNIQUE! Alert! boxes warn of common assumptions made when reading research. Recommendations for best practices in research include brief definitions of popular research terms as well as links to World Health Organization information, the latest RNAO (Registered Nurses' Association of Ontario) Best Practice Guidelines, and guidelines from Australia, the USA, the UK, and other countries. NEW! Enhanced worksheet exercises on the Evolve website demonstrate how to apply knowledge gained from the text, based on research articles drawn from Australia, Canada, Europe, and the USA, on a variety of health issues encountered in hospital and community settings.
Praise for the "Second Edition: " .".".a grand feast for biostatisticians. It stands ready to satisfy the appetite of any pharmaceutical scientist with a respectable statistical appetite." --Journal of Clinical Research Best Practices" The "Third Edition "of "Design and Analysis of Clinical Trials "provides complete, comprehensive, and expanded coverage of recent health treatments and interventions. Featuring a unified presentation, the book provides a well-balanced summary of current regulatory requirements and recently developed statistical methods as well as an overview of the various designs and analyses that are utilized at different stages of clinical research and development. Additional features of this "Third Edition "include: - New chapters on biomarker development and target clinical trials, adaptive design, trials for evaluating diagnostic devices, statistical methods for translational medicine, and traditional Chinese medicine - A balanced overview of current and emerging clinical issues as well as newly developed statistical methodologies - Practical examples of clinical trials that demonstrate everyday applicability, with illustrations and examples to explain key concepts - New sections on bridging studies and global trials, QT studies, multinational trials, comparative effectiveness trials, and the analysis of QT/QTc prolongation - A complete and balanced presentation of clinical and scientific issues, statistical concepts, and methodologies for bridging clinical and statistical disciplines - An update of each chapter that reflects changes in regulatory requirements for the drug review and approval process and recent developments in statistical design and methodology for clinical research and development "Design and Analysis of Clinical Trials, Third Edition "continues to be an ideal clinical research reference for academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students.
Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hoekfelt and V.C. Jordan.
This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.
The Biomaterials Science and Engineering Series is designed to help stimulate further developments in biomaterials science and engineering by disseminating up-to-the-minute, quality information to academic and industrial research and development scientists employed in all areas of the medical, biomedical and bioengineering sciences whether in medical device R&D, pharmaceutical and pharmacological research or materials science, and to clinical specialists in prosthetics and surgery. Contrary to popular belief, the future for metals and alloys as biomaterials is strong. State-of-the-art engineering methods, combined with the intrinsic strengths of metals, have resulted in considerably improved and new types of medical device. This timely reference provides a detailed appraisal of:
There have been very rapid advances in scientific, technical, clinical, and administrative areas of transfusion medicine since the beginning of this millennium, which need to be propagated among the workers in the field. This book is a vital tool for managerial, technical, and clinical staff in understanding the specific issues in the subject, which provide information regarding the particular aspects in the three volumes of the book. This publication was intended to provide a helpful resource to many workers in the technical and clinical fields as well as trainees and academia in the subject of transfusion medicine. The authors from developed and developing countries have contributed their knowledge in current technology, clinical support, and managerial issues. Editors have applied special attention to select authors who have practical experience on working the ground level of their specialties, especially in developing countries. A total of eighty authors across the globe have contributed fifty chapters in this three-volume textbook. Translating scientific advances to the patient creates an exciting environment for training. The textbooks in transfusion medicine are expensive for students and workers from developing countries. To achieve cost efficiency, this book is divided into three volumes: Organization and Management, Basics of Blood Bank Practices, and Good Clinical Transfusion Practices. It is thus possible to procure/buy the volume required for a specific purpose from an interested person, either from transfusion medicine or from allied specialties. The chapters in all three volumes are concise and thorough in regards to the subject for the administrative, laboratory, and clinical practices. The editors and authors have endeavored much to provide practical and instructive chapters from which readers will be able to find useful and detailed information on the subject. The editors have taken care to incorporate the necessary topics by inviting authors experienced in those subjects to write chapters providing up-to-date information. Due care is taken in editing those chapters by the editors and their associates besides the language editor. All three volumes are easily readable and full of stimulating and enlightening informative material described by these experienced authors. This book will provide a helpful resource for supporting and improving technical skills of all those who work in the field of transfusion medicine. It will keep them abreast with latest developments for the management of transfusion medicine departments and laboratories as well as assuring quality, reliability, and safety in their workplaces. This compilation will serve as a textbook for graduate and post-graduate students in transfusion medicine, hematology (and transplantations), laboratory technology, biotechnology, clinical nursing, anesthesiology, internist, and management students in healthcare services. This textbook will also serve as a reference book for practitioners from the above specialties.
This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds. |
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